Creation and validation of the first infinium DNA methylation array for the human imprintome

Autor: Natalia Carreras-Gallo, Varun B. Dwaraka, Dereje D. Jima, David A. Skaar, Tavis L. Mendez, Antonio Planchart, Wanding Zhou, Randy L. Jirtle, Ryan Smith, Cathrine Hoyo

Publikováno v: Epigenetics Communications, Vol 4, Iss 1, Pp 1-10 (2024)

Abstract Background Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formation of common chronic

Externí odkaz: https://doaj.org/article/500f8c086872444e8fdf57bfa9362c95

Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth

Autor: Adriana C. Vidal, David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, William Schlief, Cathrine Hoyo

Publikováno v: Epigenetics, Vol 19, Iss 1 (2024)

ABSTRACTAdverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial

Externí odkaz: https://doaj.org/article/0b5ee08e3e724394b583d1d95eca3652

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autor: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melén, Gemma C. Sharp, Matt J. Silver, Faisal I. Rezwan, John W. Holloway

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)

Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms under

Externí odkaz: https://doaj.org/article/d655547609c94f51b01a2521002c970a

Interplay of gestational parent exposure to ambient air pollution and diet characteristics on preterm birth

Autor: Hanna Jardel, Chantel L Martin, Cathrine Hoyo, Kristen M Rappazzo

Publikováno v: BMC Public Health, Vol 23, Iss 1, Pp 1-13 (2023)

Abstract Background Despite many efforts, preterm birth (PTB) is poorly understood and remains a major public health problem in the United States. Toxicological work suggests gestational parent (GP) diet may modify the effect of ambient pollutants on

Externí odkaz: https://doaj.org/article/148fc18865f44723833429eaf4f0151e

Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes

Autor: Dillon E. King, Anna Clare Sparling, Dillon Lloyd, Matthew Joseph Satusky, Mackenzie Martinez, Carole Grenier, Christina Michelle Bergemann, Rachel Maguire, Cathrine Hoyo, Joel Newman Meyer, Susan K. Murphy

Publikováno v: Epigenetics, Vol 17, Iss 12, Pp 1573-1589 (2022)

Sex-linked differences in mitochondrial ATP production, enzyme activities, and reactive oxygen species generation have been reported in multiple tissue and cell types. While the effects of reproductive hormones underlie many of these differences, reg

Externí odkaz: https://doaj.org/article/0770479503e94eb1bee8c0d05d00a103