Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Cathrin, Gudd"'
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Akademický článek
CD8+ T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunctionResearch in context
Autor: Fanny Lebossé, Cathrin Gudd, Enes Tunc, Arjuna Singanayagam, Rooshi Nathwani, Evangelos Triantafyllou, Oltin Pop, Naveenta Kumar, Sujit Mukherjee, Tie Zheng Hou, Alberto Quaglia, Fabien Zoulim, Julia Wendon, Ameet Dhar, Mark Thursz, Charalambos G. Antoniades, Wafa Khamri
Publikováno v: EBioMedicine, Vol 49, Iss , Pp 258-268 (2019)
ABSTRACT: Background: Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive immune dysfunctions have been described as contributors to C
Externí odkaz: https://doaj.org/article/081a539474c34548adf6b8413edd5c2e
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2
Activation and transcriptional profile of monocytes and CD8+ T cells are altered in checkpoint inhibitor-related hepatitis
Autor: Cathrin Gudd, Robert D. Goldin, Rooshi Nathwani, You Yone, Charalambos G. Antoniades, James Larkin, A. Dhar, Sujit Mukherjee, Tong Liu, Evangelos Triantafyllou, Lewis Au, Benjamin Shum, Lucia A. Possamai, Samra Turajlic, David J. Pinato, Kevin J. Woollard, Naveenta Kumar, Mark Thursz, Martin Gore, Wafa Khamri
Publikováno v: Journal of Hepatology. 75:177-189
Background & Aims: Checkpoint inhibitor-related hepatitis (CPI-Hep) is an emerging clinical challenge. We aimed to gain insights into the immunopathology of CPI-Hep by comprehensively characterising myeloid and lymphoid subsets. Methods: CPI-treated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7fa314edbf9c9cb50fcfac2f12d607
https://doi.org/10.1016/j.jhep.2021.02.008
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3
Proinflammatory CD20 + T cells contribute to CNS-directed autoimmunity
Autor: Jasmin Ochs, Nitzan Nissimov, Sebastian Torke, Marie Freier, Katja Grondey, Julian Koch, Matthias Klein, Linda Feldmann, Cathrin Gudd, Tobias Bopp, Silke Häusser-Kinzel, Martin S. Weber
Publikováno v: Science Translational Medicine. 14
The origin and function of CD20 + T cells are poorly understood. Here, we characterized CD20 + T cells in mice and humans and investigated how they are affected by anti-CD20 antibody treatment. We report that murine CD20 + T cells are unable to endog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28ebd95fdc6fd371f67fb5d6dbc4afd2
https://doi.org/10.1126/scitranslmed.abi4632
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5
CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction
Autor: Sujit Mukherjee, Evangelos Triantafyllou, Oltin T Pop, Fabien Zoulim, Enes Tunc, Alberto Quaglia, Arjuna Singanayagam, Wafa Khamri, Mark Thursz, Tie Zheng Hou, Fanny Lebossé, Julia Wendon, Rooshi Nathwani, Charalambos G. Antoniades, Cathrin Gudd, Naveenta Kumar, A. Dhar
Publikováno v: EBioMedicine
EBioMedicine, 2019, 49, pp.258-268. ⟨10.1016/j.ebiom.2019.10.011⟩
Background Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive immune dysfunctions have been described as contributors to CAID leading
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9318081e284f95b31ce34f205764d8db
http://europepmc.org/articles/PMC6945243
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7
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury
Autor: Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo
Publikováno v: The Journal of Clinical Investigation
Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57ff30014337155b03c74b6c2ac765a
https://doi.org/10.1172/jci140196
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8
Suppressor CD4
Autor: Wafa, Khamri, Cathrin, Gudd, Tong, Liu, Rooshi, Nathwani, Marigona, Krasniqi, Sofia, Azam, Thomas, Barbera, Francesca M, Trovato, Lucia, Possamai, Evangelos, Triantafyllou, Rocio Castro, Seoane, Fanny, Lebosse, Arjuna, Singanayagam, Naveenta, Kumar, Christine, Bernsmeier, Sujit, Mukherjee, Mark, McPhail, Chris J, Weston, Charalambos Gustav, Antoniades, Mark R, Thursz
Publikováno v: Gut. 71(6)
Identifying components of immuneparesis, a hallmark of chronic liver failure, is crucial for our understanding of complications in cirrhosis. Various suppressor CD4Flow cytometry was used to determine the proportion and immunophenotype of CD4Patients
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3bd286e3b044d9dfe2758c154299378
https://pubmed.ncbi.nlm.nih.gov/34344786
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