Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cathrin, Gräwe"'
Autor:
Maria Stahl Madsen, Marjoleine F. Broekema, Martin Rønn Madsen, Arjen Koppen, Anouska Borgman, Cathrin Gräwe, Elisabeth G. K. Thomsen, Denise Westland, Mariette E. G. Kranendonk, Marian Groot Koerkamp, Nicole Hamers, Alexandre M. J. J. Bonvin, José M. Ramos Pittol, Kedar Nath Natarajan, Sander Kersten, Frank C. P. Holstege, Houshang Monajemi, Saskia W. C. van Mil, Michiel Vermeulen, Birthe B. Kragelund, David Cassiman, Susanne Mandrup, Eric Kalkhoven
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Mutations in PPARγ lead to lipodystrophy, but the mechanisms by which the mutations affect the activity in chromatin is unknown. Here, Madsen, Broekema et al. showed that mutations affecting two intermolecular interactions compromise chromatin remod
Externí odkaz:
https://doaj.org/article/bb99d7ed4031494bb213b8c0686b2ffe
Autor:
Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew M. Makowski, Leandro M. Colli, Mai Xu, Rebecca C. Hennessey, Jinhu Yin, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Karen M. Funderburk, Myriam Brossard, John Taylor, Bogdan Pasaniuc, Raj Chari, Stephen J. Chanock, Clive J. Hoggart, Florence Demenais, Jennifer H. Barrett, Matthew H. Law, Mark M. Iles, Kai Yu, Michiel Vermeulen, Leonard I. Zon, Kevin M. Brown
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to
Externí odkaz:
https://doaj.org/article/670b26b5d219499083d912a34bb1bf00
Autor:
Matthew M. Makowski, Cathrin Gräwe, Benjamin M. Foster, Nhuong V. Nguyen, Till Bartke, Michiel Vermeulen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and pr
Externí odkaz:
https://doaj.org/article/c2e2ac02d50d492280b29ec96a5b844c
Autor:
Hannah K. Neikes, Katarzyna W. Kliza, Cathrin Gräwe, Roelof A. Wester, Pascal W. T. C. Jansen, Lieke A. Lamers, Marijke P. Baltissen, Simon J. van Heeringen, Colin Logie, Sarah A. Teichmann, Rik G. H. Lindeboom, Michiel Vermeulen
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91be75eb5112ff5a980e8964bb787787
https://doi.org/10.1038/s41587-023-01715-w
https://doi.org/10.1038/s41587-023-01715-w
Autor:
Simone C. Kleinendorst, Cornelia G. Spruijt, Marijke P. Baltissen, Cathrin Gräwe, Michiel Vermeulen
Publikováno v:
The Febs Journal
FEBS Journal, 288, 10, pp. 3231-3245
FEBS Journal, 288, 3231-3245
FEBS Journal, 288, 10, pp. 3231-3245
FEBS Journal, 288, 3231-3245
Thorough purification and cross‐linking of the NuRD complex from multiple angles led to a high‐density interaction network. The core is formed by MTA‐HDAC and RBBP proteins, to which MBD and GATAD2 proteins dock. The latter proteins associate w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5483dc3ff9bff3b7d189e8ff3ea23f74
https://doi.org/10.1111/febs.15650
https://doi.org/10.1111/febs.15650
Autor:
Hannah K. Neikes, Rik G.H. Lindeboom, Cathrin Gräwe, Lieke A. Lamers, Marijke P. Baltissen, Pascal W.T.C. Jansen, Simon J. van Heeringen, Colin Logie, Sarah A. Teichmann, Michiel Vermeulen
Transcription factor binding across the genome is regulated by DNA sequence and chromatin features. However, it is not yet possible to quantify the impact of chromatin context on genome-wide transcription factor binding affinities. Here we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e650d570f1c31b9535ba43adaa32dc4
https://doi.org/10.1101/2022.04.04.486948
https://doi.org/10.1101/2022.04.04.486948
Publikováno v:
Trends in Biotechnology
RNA–protein interactions play an important role in numerous cellular processes in health and disease. In recent years, the global RNA-bound proteome has been extensively studied, uncovering many previously unknown RNA-binding proteins. However, lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8f74341efd9ccd4e8d49bf0dbf0b57
https://doi.org/10.1016/j.tibtech.2020.11.011
https://doi.org/10.1016/j.tibtech.2020.11.011
Autor:
Lukas Burger, Sevi Durdu, Arnaud R Krebs, Sébastien A. Smallwood, Michiel Vermeulen, Marco Pregnolato, Daniel Hess, Luke Isbel, Leslie Hoerner, Cathrin Gräwe, Alicia K. Michael, Ralph S. Grand, Vytautas Iesmantavicius, Nicolas H. Thomä, Dirk Schübeler
Publikováno v:
Nature, 596, 133-137
Nature, 596, pp. 133-137
Nature, 596, pp. 133-137
The majority of gene transcripts generated by RNA polymerase II in mammalian genomes initiate at CpG island (CGI) promoters1,2, yet our understanding of their regulation remains limited. This is in part due to the incomplete information that we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a435a9b976d10b7b036f5de70743bd26
http://hdl.handle.net/2066/245264
http://hdl.handle.net/2066/245264
Autor:
Ralph S, Grand, Lukas, Burger, Cathrin, Gräwe, Alicia K, Michael, Luke, Isbel, Daniel, Hess, Leslie, Hoerner, Vytautas, Iesmantavicius, Sevi, Durdu, Marco, Pregnolato, Arnaud R, Krebs, Sébastien A, Smallwood, Nicolas, Thomä, Michiel, Vermeulen, Dirk, Schübeler
Publikováno v:
Nature. 596(7870)
The majority of gene transcripts generated by RNA polymerase II in mammalian genomes initiate at CpG island (CGI) promoters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfa234815c0ef69421db24fa8c55d126
https://pubmed.ncbi.nlm.nih.gov/34234345
https://pubmed.ncbi.nlm.nih.gov/34234345
Autor:
Mark M. Iles, Jennifer H. Barrett, Matthew Law, Andrew Vu, Leandro M. Colli, Bogdan Pasaniuc, Michiel Vermeulen, Stephen J. Chanock, Cathrin Gräwe, Karen M. Funderburk, John C. Taylor, Harriet Rothschild, Myriam Brossard, Leonard I. Zon, Raj Chari, Clive J. Hoggart, Kevin M. Brown, Rebecca C Hennessey, Jiyeon Choi, Kai Yu, Mai Xu, Jinhu Yin, Julien Ablain, Michael A. Kovacs, Matthew M. Makowski, Tongwu Zhang, Florence Demenais
Publikováno v:
Nature Communications
Nature Communications, 2020, 11 (1), pp.2718. ⟨10.1038/s41467-020-16590-1⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2718. ⟨10.1038/s41467-020-16590-1⟩
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, 11, 1-16
Nature Communications, 11, 1, pp. 1-16
Nature Communications, 2020, 11 (1), pp.2718. ⟨10.1038/s41467-020-16590-1⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2718. ⟨10.1038/s41467-020-16590-1⟩
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, 11, 1-16
Nature Communications, 11, 1, pp. 1-16
Genome-wide association studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally characterized. Here we report an approach integrating massively-parallel reporter assays (MPRA) with cell-type-specific epigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a4367fecae45d7f1bac0aa41d00adf
https://doi.org/10.1038/s41467-020-16590-1
https://doi.org/10.1038/s41467-020-16590-1