Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cathleen Sookdeo"'
Autor:
Sirkka Kyostio-Moore, Patricia Berthelette, Susan Piraino, Cathleen Sookdeo, Bindu Nambiar, Robert Jackson, Brenda Burnham, Catherine R O'Riordan, Seng H Cheng, Donna Armentano
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Recombinant adeno-associated viral (rAAV) vectors containing oversized genomes provide transgene expression despite low efficiency packaging of complete genomes. Here, we characterized the properties of oversized rAAV2/8 vectors (up to 5.4 kb) encodi
Externí odkaz:
https://doaj.org/article/dc83fa3e7b174a09885970c39aa9a954
Autor:
Patricia Berthelette, Bindu Nambiar, Donna Armentano, Cathleen Sookdeo, Brenda Burnham, Susan Piraino, Sirkka Kyostio-Moore, Shelley Nass, Karen A. Vincent, Seng H. Cheng, Catherine R. O'Riordan, David W. Souza, Robert B. Jackson
Publikováno v:
Human gene therapy methods. 28(1)
Several ongoing clinical studies are evaluating recombinant adeno-associated virus (rAAV) vectors as gene delivery vehicles for a variety of diseases. However, the production of vectors with genomes >4.7 kb is challenging, with vector preparations fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1e64b78540f6afd300d3eb7e89bf64
https://pubmed.ncbi.nlm.nih.gov/28166648
https://pubmed.ncbi.nlm.nih.gov/28166648
Akademický článek
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Autor:
Sirkka Kyostio-Moore, Susan Piraino, Patricia Berthelette, Bindu Nambiar, Cathleen Sookdeo, Seng H. Cheng, Armentano Donna, Catherine R. O'Riordan, Brenda Burnham, Robert B. Jackson
Publikováno v:
Molecular Therapy. 23
Severe hemophilia A patients with 4 years and consequent reduction or elimination of the need for frequent factor infusions. Similar rAAV-mediated gene transfer for hemophilia A patients is challenging due to the size of the FVIII cDNA that when comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6459686b8965cf5e5f3bfb94af939d63
Autor:
Michael A. Perricone, Cathleen Sookdeo, Samuel C. Wadsworth, Richard J. Gregory, Donna Armentano, Michael P. Smith, Judith A. St. George, Joseph Zabner
Publikováno v:
Journal of Virology. 73:7031-7034
Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f78473e279671cd0e9d5a3dd593c33
https://doi.org/10.1128/jvi.73.8.7031-7034.1999
https://doi.org/10.1128/jvi.73.8.7031-7034.1999
Autor:
Joseph Zabner, Alan E. Smith, M P Smith, Cathleen Sookdeo, Samuel C. Wadsworth, D Armentano, C Sacks, Richard J. Gregory, J A St George
Publikováno v:
Journal of Virology. 71:2408-2416
The utility of adenovirus vectors for gene therapy is limited by the transience of expression that has been observed in various in vivo models. Immunological responses to viral targets can eliminate transduced cells and cause the loss of transgene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807eaa59eee43b0b98945b2820f327a6
https://doi.org/10.1128/jvi.71.3.2408-2416.1997
https://doi.org/10.1128/jvi.71.3.2408-2416.1997
Autor:
Donna Armentano, Sirkka Kyostio-Moore, Catherine R. O'Riordan, Robert B. Jackson, Cathleen Sookdeo, Seng H. Cheng, David W. Souza, Shelley Nass, Karen A. Vincent, Brenda Burnham, Patricia Berthelette, Bindu Nambiar
Publikováno v:
Molecular Therapy. 24:S40
Recombinant adeno-associated virus (rAAV) vectors are being evaluated as gene delivery vehicles in several clinical trials. The 4.7 kb wild-type (WT) size genome of AAV presents a challenge for incorporating larger transgenes with incomplete vector g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012317521e74a92242430f1b0aa1076f
https://doi.org/10.1016/s1525-0016(16)32901-x
https://doi.org/10.1016/s1525-0016(16)32901-x
Autor:
Susan Piraino, Robert Jackson, Seng H. Cheng, Donna Armentano, Brenda Burnham, Sirkka Kyostio-Moore, Catherine R. O'Riordan, Cathleen Sookdeo, Patricia Berthelette, Bindu Nambiar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Recombinant adeno-associated viral (rAAV) vectors containing oversized genomes provide transgene expression despite low efficiency packaging of complete genomes. Here, we characterized the properties of oversized rAAV2/8 vectors (up to 5.4 kb) encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5fcd1a3979a047ee51f84c3991a72a
https://doi.org/10.1038/mtm.2016.6
https://doi.org/10.1038/mtm.2016.6
Autor:
Sirkka, Kyostio-Moore, Bindu, Nambiar, Elizabeth, Hutto, Patty J, Ewing, Susan, Piraino, Patricia, Berthelette, Cathleen, Sookdeo, Gloria, Matthews, Donna, Armentano
Publikováno v:
Comparative medicine. 61(4)
Osteoarthritis is a common joint disease that currently lacks disease-modifying treatments. Development of therapeutic agents for osteoarthritis requires better understanding of the disease and cost-effective in vivo models that mimic the human disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fca8a2cdd16481b64050d4921f55ffa
https://pubmed.ncbi.nlm.nih.gov/22330250
https://pubmed.ncbi.nlm.nih.gov/22330250
Autor:
Richard J. Gregory, Alan E. Smith, Kathleen M. Hehir, Cathleen Sookdeo, Judith A. St. George, Donna Armentano, Gregory A. Prince, Samuel C. Wadsworth
Publikováno v:
Human gene therapy. 6(10)
We describe the construction and characterization of an adenovirus type 2 vector, Ad2E4ORF6, which has been modified in the E4 region to contain only open reading frame 6. When assayed in cultured cells, Ad2E4ORF6 virus replication is slightly delaye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e12b4ae5b79677346af950836cfc1c
https://pubmed.ncbi.nlm.nih.gov/8590739
https://pubmed.ncbi.nlm.nih.gov/8590739