Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cathleen M Lake"'
Autor:
Youbin Xiang, Dai Tsuchiya, Fengli Guo, Jennifer Gardner, Scott McCroskey, Andrew Price, Eelco C Tromer, James R Walters, Cathleen M Lake, R Scott Hawley
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 5 (2023)
AbstractMeiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation. In this canonical model, the maturation of crossovers into
Externí odkaz:
https://doaj.org/article/d0d6221d5f60433298d0a371aead6329
Autor:
Cathleen M Lake, Rachel J Nielsen, Amanda M Bonner, Salam Eche, Sanese White-Brown, Kim S McKim, R Scott Hawley
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007886 (2019)
Meiotic recombination, which is necessary to ensure that homologous chromosomes segregate properly, begins with the induction of meiotic DNA double-strand breaks (DSBs) and ends with the repair of a subset of those breaks into crossovers. Here we inv
Externí odkaz:
https://doaj.org/article/4d881041bc1e449884e0c76903ae472f
Autor:
Cathleen M Lake, Rachel J Nielsen, Fengli Guo, Jay R Unruh, Brian D Slaughter, R Scott Hawley
Publikováno v:
eLife, Vol 4 (2015)
Meiotic recombination begins with the induction of programmed double-strand breaks (DSBs). In most organisms only a fraction of DSBs become crossovers. Here we report a novel meiotic gene, vilya, which encodes a protein with homology to Zip3-like pro
Externí odkaz:
https://doaj.org/article/374a93082f654501b793e89cf8a8a2d2
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1002005 (2011)
Homologous recombination in meiosis is initiated by the programmed induction of double strand breaks (DSBs). Although the Drosophila Spo11 ortholog Mei-W68 is required for the induction of DSBs during meiotic prophase, only one other protein (Mei-P22
Externí odkaz:
https://doaj.org/article/9ccb5000a2bd42a18f2eb4cf355e0052
Autor:
Scott L Page, Radhika S Khetani, Cathleen M Lake, Rachel J Nielsen, Jennifer K Jeffress, William D Warren, Sharon E Bickel, R Scott Hawley
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000194 (2008)
The synaptonemal complex (SC) is an intricate structure that forms between homologous chromosomes early during the meiotic prophase, where it mediates homolog pairing interactions and promotes the formation of genetic exchanges. In Drosophila melanog
Externí odkaz:
https://doaj.org/article/8ad41d43f6134feab3c1a3da23fcac6b
Autor:
Cathleen M. Lake, R. Scott Hawley
Publikováno v:
Current biology : CB. 31(5)
Cathleen Lake and Scott Hawley discuss the components, assembly and functional importance of the synaptonemal complex.
Autor:
R. Scott Hawley, Cathleen M. Lake
Publikováno v:
Seminars in Cell & Developmental Biology. 54:117-125
The proper execution of meiotic recombination (or crossing over) is essential for chromosome segregation during the first meiotic division, and thus this process is regulated by multiple, and often elaborate, mechanisms. Meiotic recombination begins
Autor:
Amanda M. Bonner, Kim S. McKim, Rachel J. Nielsen, Cathleen M. Lake, R. Scott Hawley, Sanese K. White-Brown, Salam Eche
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 1, p e1007886 (2019)
PLoS Genetics, Vol 15, Iss 1, p e1007886 (2019)
Meiotic recombination, which is necessary to ensure that homologous chromosomes segregate properly, begins with the induction of meiotic DNA double-strand breaks (DSBs) and ends with the repair of a subset of those breaks into crossovers. Here we inv
Autor:
R. Scott Hawley, Jonathan K. Trautman, Timothy J. Dahlem, David Grunwald, Cathleen M. Lake, Michelle Christian, Kelly J. Beumer, Daniel F. Voytas, Dana Carroll
Publikováno v:
G3: Genes|Genomes|Genetics
Zinc-finger nucleases have proven to be successful as reagents for targeted genome manipulation in Drosophila melanogaster and many other organisms. Their utility has been limited, however, by the significant failure rate of new designs, reflecting t
Autor:
R. Scott Hawley, Jeff Sekelsky, Stephanie P. Bellendir, Julie Korda Holsclaw, Cathleen M. Lake
Publikováno v:
G3: Genes|Genomes|Genetics
The recognition of DNA double-strand breaks (DSBs) using a phospho-specific antibody to the histone 2A variant has become the gold standard assay for DNA damage detection. Here we report on the development of the first monoclonal antibody to the phos