Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cathleen Cover"'
Autor:
Stefanie M. Novak, Pak Kin Wong, Cathleen Cover, Anne A. Wang, Daniela C. Zarnescu, Carol C. Gregorio, Elizabeth Juneman, Miensheng Chu, Ikeotunye Royal Chinyere
Publikováno v:
Circulation. 137:605-618
Background: Gap junction remodeling is well established as a consistent feature of human heart disease involving spontaneous ventricular arrhythmia. The mechanisms responsible for gap junction remodeling that include alterations in the distribution o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b72d29697a1a1bec6f9976ea30db2d
https://doi.org/10.1161/circulationaha.117.028976
https://doi.org/10.1161/circulationaha.117.028976
Autor:
Zachary Hernandez, Christine A. Henderson, José M. Valdez, Henk Granzier, Carol C. Gregorio, Rachel M. Mayfield, Kirk R. Hutchinson, Ki Hwan Nam, Cathleen Cover, Miensheng Chu, Christopher T. Pappas, Nima Jamilpour, Pak Kin Wong
Publikováno v:
Proceedings of the National Academy of Sciences. 112:13573-13578
Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the regulation of striated muscle thin filament assembly; its physiological function has yet to be studied. We found that knockout of Lmod2 in mice results in abnormally shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fdce2f27859e8e62181907ccac45ae
https://doi.org/10.1073/pnas.1508273112
https://doi.org/10.1073/pnas.1508273112
Autor:
Michael P. Waalkes, Andrea Fuchsbichler, Alan F. Hofmann, Oleksiy Tsybrovskyy, Cathleen Cover, Martin Wagner, Kurt Zatloukal, Hartmut Jaeschke, Michael Trauner, Hanns-Ulrich Marschall, Jie Liu, Peter Fickert, Gernot Zollner, Helmut Denk
Publikováno v:
Gastroenterology. 130:465-481
Background & Aims: Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice ( Mdr2 −/− ) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c67c7ff2633f4bfc640782453aa96e
https://doi.org/10.1053/j.gastro.2005.10.018
https://doi.org/10.1053/j.gastro.2005.10.018
Autor:
Tamara R. Knight, Cathleen Cover, John J. Lemasters, Hartmut Jaeschke, Abdellah Mansouri, Mary Lynn Bajt, Dominique Pessayre
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:879-887
Intracellular sources of peroxynitrite formation and potential targets for this powerful oxidant and nitrating agent have not been identified after acetaminophen (AAP) overdose. Therefore, we tested the hypothesis that peroxynitrite generated in mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3544efdc7bbc2651125f17a229c322
https://doi.org/10.1124/jpet.105.088898
https://doi.org/10.1124/jpet.105.088898
Autor:
Cathleen Cover, David L. Nelson, Lily Yu, Samantha A. Whitman, Carol C. Gregorio, Daniela C. Zarnescu
Publikováno v:
Circulation research. 109(3)
Rationale: The proper function of cardiac muscle requires the precise assembly and interactions of numerous cytoskeletal and regulatory proteins into specialized structures that orchestrate contraction and force transmission. Evidence suggests that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5c8b4aa1346f9cd1c97e2aeb7b26a3
https://pubmed.ncbi.nlm.nih.gov/21659647
https://pubmed.ncbi.nlm.nih.gov/21659647
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 94(1)
Mitochondrial dysfunction and internucleosomal DNA fragmentation are well-recognized features of acetaminophen (AAP)-induced hepatocyte cell death. However, the endonucleases responsible for this effect have not been identified. Apoptosis-inducing fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a102a912910a407104330297302d0927
https://pubmed.ncbi.nlm.nih.gov/16896059
https://pubmed.ncbi.nlm.nih.gov/16896059
Autor:
Cathleen Cover, Nancy W. Bethea, Margaret K. McCuskey, Edward R. Abril, Robert S. McCuskey, Hartmut Jaeschke, Yoshiya Ito
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 291(2)
Neutrophil extravasation from sinusoids is a critical step for acute inflammatory tissue injury. However, the role of sinusoidal endothelial cells (SECs) in this process remains unclear. Matrix metalloproteinases (MMPs) have been shown to involve gap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2542bd32ca259c663c1abf0fd3de35
https://pubmed.ncbi.nlm.nih.gov/16574994
https://pubmed.ncbi.nlm.nih.gov/16574994
Autor:
Anwar Farhood, Hartmut Jaeschke, Ernst Malle, Mary Lynn Bajt, Jie Liu, Cathleen Cover, Michael P. Waalkes
Publikováno v:
Toxicology and applied pharmacology. 216(1)
Neutrophils are recruited into the liver after acetaminophen (AAP) overdose but the pathophysiological relevance of this acute inflammatory response remains unclear. To address this question, we compared the time course of liver injury, hepatic neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c0285fac3b123f33eff54e95d10402
https://pubmed.ncbi.nlm.nih.gov/16781746
https://pubmed.ncbi.nlm.nih.gov/16781746
Publikováno v:
Life sciences. 78(15)
The mode of cell death after acetaminophen (AAP) overdose is controversially discussed. A recent study reported a protective effect of the pancaspase inhibitor Z-VAD-fmk against AAP toxicity in vivo but the mechanism of protection remained unclear. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c41d02e6cb002daf4eb31ae94a1df0
https://pubmed.ncbi.nlm.nih.gov/16226279
https://pubmed.ncbi.nlm.nih.gov/16226279
Autor:
Cathleen Cover, Tamara R. Knight, Hartmut Jaeschke, Peter Fickert, Andrea Fuchsbichler, Anwar Farhood, Michael Trauner
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 84(1)
DNA fragmentation in hepatocytes occurs early after acetaminophen (AAP) overdose in mice. DNA strandbreaks can induce excessive activation of poly(ADP-ribose) polymerases (PARP), which may lead to oncotic necrosis. Based on controversial findings wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0a30d3e49f76bd45f170037c8cff29
https://pubmed.ncbi.nlm.nih.gov/15601672
https://pubmed.ncbi.nlm.nih.gov/15601672