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of 7
pro vyhledávání: '"Cathleen Becker"'
Autor:
Simone Filosto, Elaine M Khan, Emiliana Tognon, Cathleen Becker, Majid Ashfaq, Tommer Ravid, Tzipora Goldkorn
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23240 (2011)
Crystallographic studies have offered understanding of how receptor tyrosine kinases from the ErbB family are regulated by their growth factor ligands. A conformational change of the EGFR (ErbB1) was shown to occur upon ligand binding, where a solely
Externí odkaz:
https://doaj.org/article/ad7c71ddeaeb48ff8095e88b9c2d16a6
Publikováno v:
Molecular Cancer Therapeutics. 12:1579-1590
The EGF receptor (EGFR) is a proto-oncogene commonly dysregulated in several cancers including non–small cell lung carcinoma (NSCLC) and, thus, is targeted for treatment using tyrosine kinase inhibitors (TKI) such as erlotinib. However, despite the
Publikováno v:
D74. MOLECULAR TARGETS AND MODEL THERAPIES FOR LUNG CANCER.
Publikováno v:
Molecular cancer therapeutics. 11(4)
The EGF receptor (EGFR) and its downstream signaling are implicated in lung cancer development. Therefore, much effort was spent in developing specific tyrosine kinase inhibitors (TKI) that bind to the EGFR ATP-pocket, blocking EGFR phosphorylation/s
Publikováno v:
C66. MOLECULAR TARGETS FOR THERAPEUTIC DEVELOPMENT IN LUNG CANCER.
Autor:
Majid Ashfaq, Emiliana Tognon, Tzipora Goldkorn, Cathleen Becker, Simone Filosto, Elaine M. Khan, Tommer Ravid
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23240 (2011)
PLoS ONE
PLoS ONE
Crystallographic studies have offered understanding of how receptor tyrosine kinases from the ErbB family are regulated by their growth factor ligands. A conformational change of the EGFR (ErbB1) was shown to occur upon ligand binding, where a solely
Publikováno v:
Free Radical Biology and Medicine. 49:S60