Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cathinka Boedicker"'
Autor:
Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 109-119 (2022)
BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis. As Bromodomain and Extra T
Externí odkaz:
https://doaj.org/article/0403c2302550453288f621f27f8c9d7f
Autor:
Vinzenz Särchen, Senthan Shanmugalingam, Sarah Kehr, Lisa Marie Reindl, Victoria Greze, Sara Wiedemann, Cathinka Boedicker, Maureen Jacob, Katrin Bankov, Nina Becker, Sibylle Wehner, Till M. Theilen, Steffen Gretser, Elise Gradhand, Carsten Kummerow, Evelyn Ullrich, Meike Vogler
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract The induction of apoptosis is a direct way to eliminate tumor cells and improve cancer therapy. Apoptosis is tightly controlled by the balance of pro- and antiapoptotic Bcl-2 proteins. BH3 mimetics neutralize the antiapoptotic function of Bc
Externí odkaz:
https://doaj.org/article/719225c3afcf45b38f706286a0432fa3
Publikováno v:
Translational Oncology, Vol 16, Iss , Pp 101313- (2022)
The RAS/MEK/ERK genetic axis is commonly altered in rhabdomyosarcoma (RMS), indicating high activity of downstream effector ERK1/2 kinase. Previously, we have demonstrated that inhibition of the RAS/MEK/ERK signaling pathway in RMS is insufficient to
Externí odkaz:
https://doaj.org/article/9a54df46b2714aad8c741ac05aa28351
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75026 (2013)
The antibacterial properties of nanosilver have led to a versatile application spectrum including medical purposes and personal care products. However, the increasing use of nanosilver has raised concerns about its environmental impacts. Long-term ex
Externí odkaz:
https://doaj.org/article/5d54d6a55cdc4c6fa21fb1343010328e
Autor:
Stefan Knapp, Christina Grimm, Cathinka Boedicker, Michal R. Schweiger, Marek Wanior, Michael Meister, Michelle Hussong, Julius C. Enßle, Nadezda Dolgikh, Simone Fulda
Publikováno v:
Oncogene. 39:3837-3852
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f17a5f30f96e64b46d2c5c25a46679
https://doi.org/10.1038/s41388-020-1229-0
https://doi.org/10.1038/s41388-020-1229-0
Autor:
Vinzenz Särchen, Senthan Shanmugalingam, Sarah Kehr, Lisa Marie Reindl, Victoria Greze, Sara Wiedemann, Cathinka Boedicker, Maureen Jacob, Katrin Bankov, Nina Becker, Sibylle Wehner, Till M. Theilen, Steffen Gretser, Elise Gradhand, Carsten Kummerow, Evelyn Ullrich, Meike Vogler
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
The induction of apoptosis is a direct way to eliminate tumor cells and improve cancer therapy. Apoptosis is tightly controlled by the balance of pro- and antiapoptotic Bcl-2 proteins. BH3 mimetics neutralize the antiapoptotic function of Bcl-2 prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d2a6b9ac841a9a26154110c284d5a430
https://pubmed.ncbi.nlm.nih.gov/35013156
https://pubmed.ncbi.nlm.nih.gov/35013156
Autor:
Donat Kögel, Cathinka Boedicker, Michael Torsten Meister, Benedikt Linder, Thomas Klingebiel, Simone Fulda
Publikováno v:
Cancer Letters. 465:1-11
In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d02fbb7d40d794b5d76e3e8c141f96e
https://doi.org/10.1016/j.canlet.2019.08.012
https://doi.org/10.1016/j.canlet.2019.08.012
Publikováno v:
Cancer letters. 486
Targeting the epigenome of cancer cells with the combination of Bromodomain and Extra Terminal (BET) protein inhibitors and histone deacetylase (HDAC) inhibitors has shown synergistic antitumor effects in several cancer types. In this study, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc9a63eda5395b8cad38c733a20b408
https://pubmed.ncbi.nlm.nih.gov/32445837
https://pubmed.ncbi.nlm.nih.gov/32445837
Publikováno v:
Cancer Letters. 429:19-28
In the present study, we show that pharmacological repression by the Hedgehog (Hh) pathway inhibitor (HPI) GANT61 induces expression of the proapoptotic protein Noxa in TP53-mutated embryonal pediatric tumor cells driven by Hh signaling (i.e. rhabdom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f1c5af257135d28212423498c954db
https://doi.org/10.1016/j.canlet.2018.04.025
https://doi.org/10.1016/j.canlet.2018.04.025
Autor:
Cathinka, Boedicker, Michelle, Hussong, Christina, Grimm, Nadezda, Dolgikh, Michael T, Meister, Julius C, Enßle, Marek, Wanior, Stefan, Knapp, Michal R, Schweiger, Simone, Fulda
Publikováno v:
Oncogene. 39(19)
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42fc73456e5354497de795944d6a312a
https://pubmed.ncbi.nlm.nih.gov/32161312
https://pubmed.ncbi.nlm.nih.gov/32161312