Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Catherine Wrench"'
Autor:
Agata Radwanska, Christopher Travis Cottage, Antonio Piras, Catherine Overed-Sayer, Carina Sihlbom, Ramachandramouli Budida, Catherine Wrench, Jane Connor, Susan Monkley, Petra Hazon, Holger Schluter, Matthew J. Thomas, Cory M. Hogaboam, Lynne A. Murray
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unmet medical need. It is characterized by formation of scar tissue leading to a progressive and irreversible decline in lung function. IPF is associated with repeated injury, which may alte
Externí odkaz:
https://doaj.org/article/893273a899624c7f8501668b4c65941b
Autor:
Jonathan R. Baker, Peter J. Barnes, Catherine Wrench, Louise E. Donnelly, Eva Delbrel, Peter Fenwick
Publikováno v:
Mechanisms of lung injury and repair.
Background: In COPD, senescence of small airway fibroblasts (SAF) is closely related to the oxidative imbalance. The SAF secretome is characterised by a pro-inflammatory pattern that may drive small airway fibrosis. Molecular events leading to senesc
Publikováno v:
B63. EXPLORING COPD BY MARKER, MECHANISM, AND SIGNATURES.
Publikováno v:
03.02 - Airway cell biology and immunopathology.
Introduction: COPD is associated with cellular senescence, hallmarks of which include increased cell size, autofluorescence, senescence associated-β-galactosidase (SA-β-Gal) staining, mitochondrial dysfunction, reduced proliferation and cell cycle
Autor:
Peter Fenwick, P. J. Barnes, E Delbrel, Catherine Wrench, Jonathan R. Baker, Louise E. Donnelly
Publikováno v:
03.02 - Airway cell biology and immunopathology.
Background: Senescence is a critical cellular process involved in COPD progression. The molecular mechanisms that trigger senescence in small airways fibroblasts (SAF) are not clearly identified. These cells secrete proinflammatory cytokines and resi
Autor:
Catherine Wrench, Darius Armstrong-James, Louise E. Donnelly, Anand Shah, Amelia Bercusson, Peter J. Barnes, Kylie B. R. Belchamber
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:271-273
Publikováno v:
Airway cell biology and immunopathology.
Rationale: Pulmonary fibroblasts proliferate and produce extracellular matrix to repair the lung environment. In COPD, parenchymal-derived fibroblasts exhibit reduced proliferation possibly due to growth arrest via cellular senescence. However, the p
Publikováno v:
B28. HOW AIRWAYS MALFUNCTION: NEW CONCEPTS.
Publikováno v:
Airway Cell Biology and Immunopathology.
Background: Progressive small airway fibrosis is a key feature of early COPD. In COPD, cellular senescence levels are increased and may relate to disease progression. Peripheral parenchymal fibroblasts are pro-inflammatory and dysfunctional in COPD,
Publikováno v:
Airway Cell Biology and Immunopathology.
Background: COPD is a disease of accelerated lung aging and is associated with elevated cellular senescence. Increased senescent fibroblasts are seen in small airways of patients with COPD, which may contribute to disease progression via progressive