Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Catherine W. Goh"'
Autor:
Meng S. Choy, Permeen Yusoff, Irene C. Lee, Jocelyn C. Newton, Catherine W. Goh, Rebecca Page, Shirish Shenolikar, Wolfgang Peti
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1885-1891 (2015)
The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine protein phosphatase 1 (PP1) is t
Externí odkaz:
https://doaj.org/article/689ac6fbfbd04b1988e1431c046b7bdd
Publikováno v:
Drug Metabolism and Disposition. 39:402-411
Physiological alterations that may change pharmacological response accompany aging. Pharmacokinetic/pharmacodynamic properties of cholinesterase inhibitors (ChEIs) used in the treatment of Alzheimer's disease, donepezil, tacrine, and galantamine, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57892ed51050f3310f424426cb373031
https://doi.org/10.1124/dmd.110.035964
https://doi.org/10.1124/dmd.110.035964
Autor:
Catherine W. Goh, Edward R. Browne, Aveline H. Neo, Lee Sun New, Hui Ting Chng, Eric Chun Yong Chan
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 51:754-757
A sensitive liquid chromatography tandem mass spectrometry (LC/MS/MS) bioanalytical method was developed and validated to analyze lipoic acid (LA) in rat blood and brain samples. Ten mobile phase combinations were investigated during method developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef73ea9cd54e26a8342c5924eb37248
https://doi.org/10.1016/j.jpba.2009.09.028
https://doi.org/10.1016/j.jpba.2009.09.028
Autor:
Edward R. Browne, Catherine W. Goh, Lee Sun New, Lee Cheng Phua, Eric Chun Yong Chan, Aveline H. Neo
Publikováno v:
Pharmaceutical Research. 25:2639-2649
To investigate the potential drug–drug interaction (DDI) between lipoic acid (LA) and valproate (VA) via the mitochondrial β-oxidation pathway in rats. In vitro mitochondrial assays were performed to compare the biotransformation of VA to valproyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53c0efc1c35a34cf544988f6dc01d8d
https://doi.org/10.1007/s11095-008-9681-5
https://doi.org/10.1007/s11095-008-9681-5
Publikováno v:
Hepatology. 45:412-421
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses but which can precipitate liver injury at high doses. We have previously found that the antirheumatic drug leflunomide is a potent inhibitor of APA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4b4a18d5617a5ca7fe5cb894146485
https://doi.org/10.1002/hep.21475
https://doi.org/10.1002/hep.21475
Autor:
Eric Chun Yong Chan, Kai Lun Chang, Edward R. Browne, Chiu Cheong Aw, Catherine W. Goh, Lee Sun New, Mainak Mal
Publikováno v:
Journal of proteome research. 10(4)
3-Nitropropionic acid (3-NP), a potent irreversible inhibitor of mitochondrial complex II enzyme, leads to mitochondrial dysfunction and oxidative stress in Huntington's disease (HD) rat model. In this study, biochemical assays were used to demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c20d6dbc542473f0d3725513b80717
https://pubmed.ncbi.nlm.nih.gov/21355552
https://pubmed.ncbi.nlm.nih.gov/21355552
Autor:
Dilys P. Q. Goh, Aveline H. Neo, Catherine W. Goh, Chiu Cheong Aw, Lee Sun New, Woei Shin Chen, Zeenat Atcha, Edward R. Browne, Eric C. Y. Chan
Publikováno v:
Journal of Proteome Research; Dec2009, Vol. 8 Issue 12, p5679-5690, 12p