Virtual Physiological Human research initiative: the future for rational HIV treatment design?

Autor: Peter V. Coveney, Ileana Stoica, S. Kashif Sadiq, Catherine V. Gale

Publikováno v: Future HIV Therapy. 2:419-425

The clinical management of HIV-positive patients receiving existing drug regimens is performed largely as a clinician’s best guess, based on available viral and patient data. The development of new antiretroviral therapies for HIV is at an impasse.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f313fd908b71f9a7ebfa20ce2b4e603d
https://doi.org/10.2217/17469600.2.5.419

X Box Binding Protein XBP-1s Transactivates the Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF50 Promoter, Linking Plasma Cell Differentiation to KSHV Reactivation from Latency

Autor: Ming-Qing Du, Benjamin L. J. Webb, Catherine V. Gale, Christoforos Tsantoulas, Edward H. Tsao, Lucy Dalton-Griffin, Adrian Whitehouse, Paul Kellam, Sam J. Wilson, Hongtao Ye

Publikováno v: Journal of Virology. 81:13578-13586

Reactivation of lytic replication from viral latency is a defining property of all herpesviruses. Despite this, the authentic physiological cues for the latent-lytic switch are unclear. Such cues should ensure that viral lytic replication occurs unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48aede7870d73154ad45c2fbc13a20e1
https://doi.org/10.1128/jvi.01663-07

Assessment of automated genotyping protocols as tools for surveillance of HIV-1 genetic diversity

Autor: Anne-Mieke Vandamme, Robert W. Shafer, Tulio de Oliveira, Andrew Rambaut, David Dunn, Robert J. Gifford, Richard Myers, Catherine V. Gale, Deenan Pillay, Paul Kellam

Publikováno v: AIDS (London, England). 20(11)

Background: The routine use of drug resistance testing provides an abundant source of HIV-1 sequence data. However, it is not clear how reliable standard genotyping of these sequences is for describing HIV-1 genetic variation and for detecting novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d15e8411f4cf72f1d33c264b7efd59d
https://pubmed.ncbi.nlm.nih.gov/16847407

Genomic analysis of host pathogen interactions

Autor: Paul Kellam, Catherine V. Gale

Publikováno v: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Infection of multicellular organisms by microbes occurs throughout, and can shape, the evolutionary history of both the host and the pathogen. Following exposure, transcriptional remodeling of infected cells and cells of the innate and adaptive arms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c074e5b392f71d5b319a5b708891a98
https://doi.org/10.1002/047001153x.g208304

Patient-specific simulation as a basis for clinical decision-making.

Autor: S. Kashif Sadiq, Marco D. Mazzeo, Stefan J. Zasada, Steven Manos, Ileana Stoica, Catherine V. Gale, Simon J. Watson, Paul Kellam, Stefan Brew, Peter V. Coveney

Publikováno v: Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences; Sep2008, Vol. 366 Issue 1878, p3199-3219, 21p