Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Catherine Treichel"'
Autor:
Jimin Lee, Cameron Stewart, Alexandra Schäfer, Elizabeth M. Leaf, Young-Jun Park, Daniel Asarnow, John M. Powers, Catherine Treichel, Kaitlin R. Sprouse, Davide Corti, Ralph Baric, Neil P. King, David Veesler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a v
Externí odkaz:
https://doaj.org/article/780e43f46b0341b2b056a3f52e383c25
Autor:
Isaac D. Lutz, Shunzhi Wang, Christoffer Norn, Alexis Courbet, Andrew J. Borst, Yan Ting Zhao, Annie Dosey, Longxing Cao, Jinwei Xu, Elizabeth M. Leaf, Catherine Treichel, Patrisia Litvicov, Zhe Li, Alexander D. Goodson, Paula Rivera-Sánchez, Ana-Maria Bratovianu, Minkyung Baek, Neil P. King, Hannele Ruohola-Baker, David Baker
Publikováno v:
Science. 380:266-273
As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approa