Výsledky vyhledávání - "Catherine Tighe"

Asymmetric Synthesis of Benzothiophene-Containing Lipoxin A4 Analogues with Lower-Chain Modifications

Autor: Patrick J. Guiry, Catherine Tighe, Benjamin Owen

Publikováno v: Synthesis. 55:1274-1284

Lipoxins are an important class of pro-resolving mediators that play a crucial role in the resolution of inflammation. Thus, the synthesis of more metabolically stable synthetic lipoxin analogues is an area of significant interest. Herein the asymmet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b3566610331e610c39855fc24afbc4
https://doi.org/10.1055/a-1992-7148

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Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms)

Autor: Catherine Tighe, Monica de Gaetano, Andrea Zanetti, Catherine Godson, Jianmin Chen, Patrick J. Guiry, Mark E. Cooper, Xavier Leroy, Kevin Gahan, Eoin P. Brennan, Derek W. Gilroy, Antonino Cacace, Mauro Perretti, Mariam Marai, Justine Newson, Andrew Gaffney, Phillip Kantharidis

Publikováno v: Journal of Medicinal Chemistry

Failure to resolve inflammation underlies many prevalent pathologies. Recent insights have identified lipid mediators, typified by lipoxins (LXs), as drivers of inflammation resolution, suggesting potential therapeutic benefit. We report the asymmetr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0a8aae72d9162c7a12aafaa264eb1
https://doi.org/10.1021/acs.jmedchem.1c00403

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Temporary thio-derivatization in the synthesis of (+)-4-acetylbromoxone

Autor: Aisling O'Byrne, Catherine Tighe, Steven O'Reilly, Laura Ciuffini, M. Gabriella Santoro, Paul Evans

Publikováno v: Tetrahedron Letters. 53:5936-5938

A stereocontrolled synthesis of the marine natural products (+)-bromoxone (1) and (+)-4-acetylbromoxone (2) is reported. The sequence features the enzymatic kinetic resolution of 4-hydroxycyclohexenone (6) via its S-benzyl adduct. Thereafter, a base-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78e305f1c20a2015d79003aad44a58e
https://doi.org/10.1016/j.tetlet.2012.08.101

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Guaranteed clean

Autor: Catherine, Tighe

Publikováno v: Nursing Standard. 22:21-21

Patients' anxiety about hospital hygiene led nurses in Cumbriato devise reassuring welcome cards.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab71f29c8226691aa67df6062e41b695
https://doi.org/10.7748/ns.22.34.21.s26

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