Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Catherine Tachdjian"'
Autor:
Nicole B. Servant, Mark E. Williams, Paul F. Brust, Huixian Tang, Melissa S. Wong, Qing Chen, Marketa Lebl-Rinnova, Sara L. Adamski-Werner, Catherine Tachdjian, Guy Servant
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The sweet taste receptor is rather unique, recognizing a diverse repertoire of natural or synthetic ligands, with a surprisingly large structural diversity, and with potencies stretching over more than six orders of magnitude. Yet, it is not clear if
Externí odkaz:
https://doaj.org/article/9d914c5347d74a30adf157b87bbb8adf
Autor:
Donald S. Karanewsky, Guy Servant, Hanghui Liu, Bert Chi, Lily Ida, Michael Saganich, Sara Werner, Joseph R. Fotsing, Andrew Patron, Catherine Tachdjian, Amy Arthur
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 507-520 (2017)
A toxicological evaluation of N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218; CAS 1622458-34-7), a flavour with modifying properties, was completed for the purpose of assessin
Externí odkaz:
https://doaj.org/article/e104bf811a6b41778b1fd0b467f96e72
Autor:
Lan Zhang, Hanghui Liu, Brett Weylan Ching, Guy Servant, Tanya Ditschun, Andrew Patron, Thomas Brady, Mark C. Williams, Melissa Arellano, Vincent Darmohusodo, Michael Saganich, Qing Chen, Timothy Davis, Catherine Tachdjian, Donald S. Karanewsky, Joseph R. Fotsing
Publikováno v:
Journal of medicinal chemistry. 63(9)
In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blocker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bf37e3c7509316160de3e35812932e
https://pubmed.ncbi.nlm.nih.gov/32330040
https://pubmed.ncbi.nlm.nih.gov/32330040
Autor:
Bert Chi, Andrew Patron, Michael Saganich, Sara Werner, Catherine Tachdjian, Guy Servant, Amy J. Arthur, Joseph R. Fotsing, Lily Ida, Hanghui Liu, Donald S. Karanewsky
Publikováno v:
Toxicology Reports, Vol 4, Iss, Pp 507-520 (2017)
Toxicology Reports
Toxicology Reports
Graphical abstract The results of the ADME, genotoxicity, rodent toxicology and developmental toxicology studies conducted on a new flavour compound S2218 are reported. S2218 is a positive allosteric modifier (PAM) of the human sweet taste receptor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdef84c8da13f7445a16395430628f3
https://doi.org/10.1016/j.toxrep.2017.09.004
https://doi.org/10.1016/j.toxrep.2017.09.004
Publikováno v:
Biomolecular Concepts, Vol 2, Iss 4, Pp 327-332 (2011)
Excess sugar intake posts several health problems. Artificial sweeteners have been used for years to reduce dietary sugar content, but they are not ideal substitutes for sugar owing to their off-taste. A new strategy focused on allosteric modulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08e630e5908da74c2bcc632d281c39c
https://doi.org/10.1515/bmc.2011.021
https://doi.org/10.1515/bmc.2011.021
Publikováno v:
Tetrahedron. 51:1887-1892
Three 1-hydroxy-3-phenylsulphonylpiperidine-2-thione derivatives have been prepared from methylphenylsulphone in five steps. The key step was the preparation of a dithioester which was achieved in a very high yield using nBuLi, CS 2 , and MeI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1805dc5141c49d71e07dc1e491e2f075
https://doi.org/10.1016/0040-4020(94)01079-f
https://doi.org/10.1016/0040-4020(94)01079-f
Publikováno v:
Trends in pharmacological sciences. 32(11)
A diet low in carbohydrates helps to reduce the amount of ingested calories and to maintain a healthy weight. With this in mind, food and beverage companies have reformulated a large number of their products, replacing sugar or high fructose corn syr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e61d35edf517f8dc342ba006bc8574
https://pubmed.ncbi.nlm.nih.gov/21807420
https://pubmed.ncbi.nlm.nih.gov/21807420
Autor:
Goran Petrovic, Feng Zhang, Xiao-Qing Tang, Catherine Tachdjian, Grant E. Dubois, Tanya Ditschun, Sara Werner, Mark Zoller, Poonit Kamdar, Paul Brust, Donald S. Karanewsky, Guy Servant, Antoniette Java, Xiaodong Li, Nicole Brune
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(10)
To identify molecules that could enhance sweetness perception, we undertook the screening of a compound library using a cell-based assay for the human sweet taste receptor and a panel of selected sweeteners. In one of these screens we found a hit, SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d2ae7fdd116ea297cfa5ef6aa93369
https://pubmed.ncbi.nlm.nih.gov/20173092
https://pubmed.ncbi.nlm.nih.gov/20173092
Autor:
Guy Servant, Haitian Liu, Catherine Tachdjian, Feng Zhang, Hong Xu, Boris Klebansky, Richard M. Fine, Mark Zoller, Xiaodong Li
Positive allosteric modulators of the human sweet taste receptor have been developed as a new way of reducing dietary sugar intake. Besides their potential health benefit, the sweet taste enhancers are also valuable tool molecules to study the genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff1393eed61ca40fee59198226f5c27
https://europepmc.org/articles/PMC2842058/
https://europepmc.org/articles/PMC2842058/
Publikováno v:
Tetrahedron. 48:7109-7120
Xanthate derivatives of β-hydroxy sulfones react with methyl radicals generated from the photolysis of N-acetyloxy-2-thiopyridone to give the corresponding olefin. Under identical conditions a secondary alcohol is transformed into its thiopyridyl de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b10ed8e630f1c13bd6d9e3bee5dd035
https://doi.org/10.1016/s0040-4020(01)88251-x
https://doi.org/10.1016/s0040-4020(01)88251-x