Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Catherine Spowart"'
Autor:
Bernie Carter, Lucy Bray, Nadia al-Najjar, Agnès Tort Piella, Catrin Tudur-Smith, Catherine Spowart, Amber Collingwood, Holly Crudgington, Janet Currier, Dyfrig A. Hughes, Eifiona Wood, Rachael Martin, Christopher Morris, Deborah Roberts, Alison Rouncefield-Swales, Heather Sutherland, Victoria Watson, Georgia Cook, Luci Wiggs, Paul Gringras, Deb Pal
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background In paediatric epilepsy, the evidence of effectiveness of antiseizure treatment is inconclusive for some types of epilepsy. As with other paediatric clinical trials, researchers undertaking paediatric epilepsy clinical trials face
Externí odkaz:
https://doaj.org/article/07d0faba807b46b9bc1bed2c6a3b8ac5
Autor:
Bernie Carter, Paul Gringras, Harriet Hiscock, Lucy Bray, Janet Currier, Catrin Tudur Smith, Dyfrig Hughes, Christopher Morris, LUCI WIGGS, Deborah Roberts, Catherine Spowart, Deb K Pal, Georgia Cook, Lucy Stibbs-Eaton, Victoria Watson, Holly Saron, Holly Crudgington, Nadia Al-Najjar, Advisory Panel CASTLE, Amber Collingwood, Kristina Charlotte Dietz, Will A S Hardy, Alison Rouncefield-Swales, Liam Whittle, Eifiona Wood
Publikováno v:
BMJ Open, Vol 13, Iss 3 (2023)
Introduction Sleep and epilepsy have an established bidirectional relationship yet only one randomised controlled clinical trial has assessed the effectiveness of behavioural sleep interventions for children with epilepsy. The intervention was succes
Externí odkaz:
https://doaj.org/article/99f4194e9e6549d79f9636baed3c857b
Autor:
Sudeep Pushpakom, Ruwanthi Kolamunnage-Dona, Claire Taylor, Terry Foster, Catherine Spowart, Marta Garcia-Finana, Graham J Kemp, Thomas Jaki, Saye Khoo, Paula Williamson, Munir Pirmohamed
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 6, Iss 6 (2019)
Background: Combination antiretroviral therapy (cART) is the standard for human immunodeficiency virus (HIV) infection treatment but can result in metabolic abnormalities, such as insulin resistance, dyslipidaemia and lipodystrophy, which can increas
Externí odkaz:
https://doaj.org/article/d8e48ba2ac624feebe41e795e55bbf8a
Autor:
Hans de Graaf, Priya Sukhtankar, Barbara Arch, Nusreen Ahmad, Amanda Lees, Abigail Bennett, Catherine Spowart, Helen Hickey, Annmarie Jeanes, Kate Armon, Andrew Riordan, Jethro Herberg, Scott Hackett, Carrol Gamble, Delane Shingadia, Ann Pallett, Stuart C Clarke, Philip Henman, Marieke Emonts, Mike Sharland, Adam Finn, Andrew J Pollard, Colin Powell, Peter Marsh, Claire Ballinger, Paula R Williamson, Nicholas MP Clarke, Saul N Faust
Publikováno v:
Health Technology Assessment, Vol 21, Iss 48 (2017)
Background: There is little current consensus regarding the route or duration of antibiotic treatment for acute osteomyelitis (OM) and septic arthritis (SA) in children. Objective: To assess the overall feasibility and inform the design of a future r
Externí odkaz:
https://doaj.org/article/051d4797a100421396f7f7b44baa5860
Autor:
Andrew Wolf, Andrew McKay, Catherine Spowart, Heather Granville, Angela Boland, Stavros Petrou, Adam Sutherland, Carrol Gamble
Publikováno v:
Health Technology Assessment, Vol 18, Iss 71 (2014)
Background: Children in paediatric intensive care units (PICUs) require analgesia and sedation but both undersedation and oversedation can be harmful. Objective: Evaluation of intravenous (i.v.) clonidine as an alternative to i.v. midazolam. Design:
Externí odkaz:
https://doaj.org/article/2ed0a9b6d25b456ba4d3c2a5116bbb0e
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e51787 (2013)
BackgroundAdequate sedation is crucial to the management of children requiring assisted ventilation on Paediatric Intensive Care Units (PICU). The evidence-base of randomised controlled trials (RCTs) in this area is small and a trial was planned to c
Externí odkaz:
https://doaj.org/article/1aedb1291627467d9f3180aa74fe1891
Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy
Autor:
John Farrant, Susanna Dodd, Carly Vaughan, Anna Reid, Matthias Schmitt, Clifford Garratt, Mohammed Akhtar, Masliza Mahmod, Stefan Neubauer, Robert M Cooper, Sanjay K Prasad, Anvesha Singh, Ladislav Valkovič, Betty Raman, Zakariye Ashkir, Dannii Clayton, Olatz Baroja, Beatriz Duran, Catherine Spowart, Emma Bedson, Josephine H Naish, Chris Harrington, Christopher A Miller
Publikováno v:
Heart. :heartjnl-2022
AimsHypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy (LVH), myocardial fibrosis, enhanced oxidative stress and energy depletion. Unbound/loosely bound tissue copper II ions are powerful catalysts of oxidative stress
Autor:
Marian Knight, Catherine Spowart, Priya Francis, Daniel C. Perry, Barbara Arch, Duncan Appelbe
Publikováno v:
Bone & Joint Open
Introduction There is widespread variation in the management of rare orthopaedic disease, in a large part owing to uncertainty. No individual surgeon or hospital is typically equipped to amass sufficient numbers of cases to draw robust conclusions fr
Autor:
Marian Knight, Duncan Appelbe, Daniel C. Perry, Barbara Arch, Priya Francis, Catherine Spowart
Publikováno v:
Bone & joint open
Bone & Joint Open
Bone & Joint Open
Aims Slipped capital femoral epiphysis (SCFE) is one of the most common hip diseases of adolescence that can cause marked disability, yet there is little robust evidence to guide treatment. Fundamental aspects of the disease, such as frequency, are u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebdebf5ff5a40b842c2258dbb45fe11
Autor:
Tracey Sach, Luke A. J. O'Neill, Ashley P Jones, Anna Rosala-Hallas, S Baron, F. Browne, Mandy Wan, C. Walker, Paula R Williamson, Carsten Flohr, Leonie S. Taams, Alan D. Irvine, F. Ashoor, Nicholas J. A. Webb, Catherine Spowart, P.E. Beattie
Publikováno v:
Irvine, A D, Jones, A P, Beattie, P, Baron, S, Browne, F, Ashoor, F, O'Neill, L, Rosala-Hallas, A, Sach, T, Spowart, C, Taams, L, Walker, C, Wan, M, Webb, N, Williamson, P, Flohr, C 2018, ' A randomised controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate versus ciclosporin in the treatment of severe atopic eczema in children : The TREatment of severe Atopic eczema Trial (TREAT) ', British Journal of Dermatology . https://doi.org/10.1111/bjd.16717
BRITISH JOURNAL OF DERMATOLOGY
BRITISH JOURNAL OF DERMATOLOGY
BACKGROUND: Oral systemic immuno-modulatory medication is regularly used off-licence in children with severe atopic eczema. However, there is no firm evidence regarding the effectiveness, safety, cost-effectiveness and impact on quality of life from