Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Catherine Smith-Maxwell"'
Autor:
Elfatih Elzein, Kobayashi Tetsuya, Brian Stafford, Ryoko Hirakawa, Nevena Mollova, Sridharan Rajamani, Belem Avila, Catherine Smith-Maxwell, Thao Perry, Lin Wu, Jennifer Tang, Jeff Zablocki, Xiaofen Li, Wei-Qun Wang, Dmitry Koltun, Parkhill Eric Q, Robert Jiang, Arvinder Dhalla, Luiz Belardinelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3207-3211
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe40fe24221536f142ea4df6dd02ec
https://doi.org/10.1016/j.bmcl.2016.03.096
https://doi.org/10.1016/j.bmcl.2016.03.096
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef515260de6068eed1fe5a0177f0bb65
https://doi.org/10.1016/j.bmcl.2016.03.101
https://doi.org/10.1016/j.bmcl.2016.03.101
Autor:
John C. Shryock, Dennis R. Tabuena, Cheng Xie, Kim W. Chan, Luiz Belardinelli, Catherine Smith-Maxwell
Publikováno v:
Biophysical Journal. (3):324a
Amino acid residues F1760 and Y1767 in S6/Domain IV of voltage gated Na+ channels are part of the local anesthetic binding site in the inner mouth of the pore. Mutagenesis experiments have shown that use-dependent block (UDB) of the cardiac hNaV1.5 N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0230458181ebad0bcf30fa46217fbf1
Autor:
Saranna Brugger, Marco Garate, Gina Papaianni, Maria Volnoukhin, Chris Zhan, Sikander Gill, Sophia Liang, Dong Liang
Publikováno v:
Assay & Drug Development Technologies; Dec2011, Vol. 9 Issue 6, p571-579, 9p
Publikováno v:
American Journal of Physiology: Cell Physiology; Feb1990, Vol. 258 Issue 2, pC234-C242, 9p