Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Catherine Smedley"'
Autor:
Olga Ucar, Kaiyong Li, Dmytro Dvornikov, Clemens Kreutz, Jens Timmer, Sonja Matt, Lukas Brenner, Catherine Smedley, Mark A. Travis, Thomas G. Hofmann, Ursula Klingmüller, Bruno Kyewski
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 448-457 (2016)
Adult tissue-specific stem cells (SCs) mediate tissue homeostasis and regeneration and can give rise to all lineages in the corresponding tissue, similar to the early progenitors that generate organs in the first place. However, the developmental ori
Externí odkaz:
https://doaj.org/article/8d995da16e3c4c9191e2d68c8b6891ca
Autor:
John J Worthington, Joanna E Klementowicz, Sayema Rahman, Beata I Czajkowska, Catherine Smedley, Herman Waldmann, Tim Sparwasser, Richard K Grencis, Mark A Travis
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003675 (2013)
Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite i
Externí odkaz:
https://doaj.org/article/896c37c39a0648e6bc82b41a1f9e89d0
Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection withFrancisella tularensis
Autor:
Joshua Dow, Urszula M. Cytlak, Joshua Casulli, Craig P. McEntee, Catherine Smedley, Suzanne H. Hodge, Riccardo V. D’Elia, Matthew R. Hepworth, Mark A. Travis
Publikováno v:
The Journal of Immunology. 210:618-627
Innate lymphoid cells (ILCs) are capable of rapid response to a wide variety of immune challenges, including various respiratory pathogens. Despite this, their role in the immune response against the lethal intracellular bacterium Francisella tularen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1625abd5a79e5323fd712a1c440b197f
https://doi.org/10.4049/jimmunol.2100651
https://doi.org/10.4049/jimmunol.2100651
Autor:
Bruno Kyewski, Ursula Klingmüller, Clemens Kreutz, Dmytro Dvornikov, Lukas Brenner, Olga Ucar, Catherine Smedley, Mark A. Travis, Jens Timmer, Sonja Matt, Thomas G. Hofmann, Kaiyong Li
Publikováno v:
Cell Reports
Ucar, O, Li, K, Dvornikov, D, Kreutz, C, Timmer, J, Matt, S, Brenner, L, Smedley, C, Travis, M, Hofmann, T G, Klingmüller, U & Kyewski, B 2016, ' A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β ', Cell Reports, vol. 17, no. 2, pp. 448-457 . https://doi.org/10.1016/j.celrep.2016.09.027
Cell Reports, Vol 17, Iss 2, Pp 448-457 (2016)
Ucar, O, Li, K, Dvornikov, D, Kreutz, C, Timmer, J, Matt, S, Brenner, L, Smedley, C, Travis, M, Hofmann, T G, Klingmüller, U & Kyewski, B 2016, ' A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β ', Cell Reports, vol. 17, no. 2, pp. 448-457 . https://doi.org/10.1016/j.celrep.2016.09.027
Cell Reports, Vol 17, Iss 2, Pp 448-457 (2016)
Summary Adult tissue-specific stem cells (SCs) mediate tissue homeostasis and regeneration and can give rise to all lineages in the corresponding tissue, similar to the early progenitors that generate organs in the first place. However, the developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ff3d1a7381013d6399bd60c895748f
https://doi.org/10.1016/j.celrep.2016.09.027
https://doi.org/10.1016/j.celrep.2016.09.027
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation
Autor:
Aoife, Kelly, Sezin, Gunaltay, Craig P, McEntee, Elinor E, Shuttleworth, Catherine, Smedley, Stephanie A, Houston, Thomas M, Fenton, Scott, Levison, Elizabeth R, Mann, Mark A, Travis
Publikováno v:
The Journal of Experimental Medicine
TGFβ is a crucial immune regulator and attractive therapeutic target but needs to be activated to function. Kelly et al. show that human monocytes and macrophages activate TGFβ via expression of an integrin, αvβ8, which dampens pro-inflammatory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59192981295c61962e0e74245e4ca0e0
https://pubmed.ncbi.nlm.nih.gov/30355614
https://pubmed.ncbi.nlm.nih.gov/30355614
Autor:
Catherine Smedley, Richard K. Grencis, Joanna E. Klementowicz, Beata I. Czajkowska, Tim Sparwasser, Sayema Rahman, Mark A. Travis, John J. Worthington, Herman Waldmann
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 9, Iss 10, p e1003675 (2013)
Worthington, J J, Klementowicz, J E, Rahman, S, Czajkowska, B I, Smedley, C, Waldmann, H, Sparwasser, T, Grencis, R K & Travis, M A 2013, ' Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity ', PL o S Pathogens, vol. 9, no. 10, e1003675 . https://doi.org/10.1371/journal.ppat.1003675, https://doi.org/10.1371/journal.ppat.1003675
PLoS Pathogens, Vol 9, Iss 10, p e1003675 (2013)
Worthington, J J, Klementowicz, J E, Rahman, S, Czajkowska, B I, Smedley, C, Waldmann, H, Sparwasser, T, Grencis, R K & Travis, M A 2013, ' Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity ', PL o S Pathogens, vol. 9, no. 10, e1003675 . https://doi.org/10.1371/journal.ppat.1003675, https://doi.org/10.1371/journal.ppat.1003675
Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc43acf4a3725e70ba0fe7986a723167
https://ora.ox.ac.uk/objects/uuid:e2cf8332-9f5a-45a4-9087-d4e7b5f390a4
https://ora.ox.ac.uk/objects/uuid:e2cf8332-9f5a-45a4-9087-d4e7b5f390a4
Autor:
John J, Worthington, Aoife, Kelly, Catherine, Smedley, David, Bauché, Simon, Campbell, Julien C, Marie, Mark A, Travis
Publikováno v:
Immunity
Summary Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da8bfbc9c3926f39dc8ee3588ea36411
https://pubmed.ncbi.nlm.nih.gov/25979421
https://pubmed.ncbi.nlm.nih.gov/25979421
Autor:
Mark A Travis, Aoife Kelly, Elinor Shuttleworth, Thomas Fenton, Catherine Smedley, Scott Levison
Publikováno v:
The Journal of Immunology. 196:207.7-207.7
Transforming growth factor beta (TGFβ) plays a key role in maintaining immune homeostasis, both preventing inflammation and promoting tissue repair. The cytokine is secreted as an inactive complex, with the function of TGFβ tightly regulated at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6950aaf87febb4a376cd1d9ffa1b2af9
https://doi.org/10.4049/jimmunol.196.supp.207.7
https://doi.org/10.4049/jimmunol.196.supp.207.7
Autor:
Mark Travis, Aoife Kelly, Catherine Smedley, David Bauché, Simon Campbell, Julien Marie, John Worthington
Publikováno v:
The Journal of Immunology. 194:48.7-48.7
Foxp3+ regulatory T-cells (Tregs) play a pivotal role in suppressing self-harmful T-cell responses to prevent inflammatory disease. An important cytokine in the development and function of Tregs is TGFβ, a latent cytokine that must be activated to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3373bea6868202aa599aab4a5cdaba9
https://doi.org/10.4049/jimmunol.194.supp.48.7
https://doi.org/10.4049/jimmunol.194.supp.48.7