Výsledky vyhledávání - "Catherine Shepherd"

Akademický článek

Of dogs and hookworms: man’s best friend and his parasites as a model for translational biomedical research

Autor: Catherine Shepherd, Phurpa Wangchuk, Alex Loukas

Publikováno v: Parasites & Vectors, Vol 11, Iss 1, Pp 1-16 (2018)

Abstract We present evidence that the dog hookworm (Ancylostoma caninum) is underutilised in the study of host-parasite interactions, particularly as a proxy for the human-hookworm relationship. The inability to passage hookworms through all life sta

Externí odkaz: https://doaj.org/article/81ed7e4dda5e4e71be2d010e1e314c11

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Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Autor: John J. Miles, Malcolm J. McConville, Phurpa Wangchuk, Norelle L. Daly, Luke Becker, Rachael Y. M. Ryan, Catherine Shepherd, Alex Loukas, Paul R. Giacomin, Linda Jones, Geraldine Buitrago, David Wilson, Konstantinos A. Kouremenos, Constantin Constantinoiu

Publikováno v: Infection and immunity. 87(4)

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a73724a0bab294b1b695a7d9a0c6ae
https://pubmed.ncbi.nlm.nih.gov/30670556

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Hookworm-derived small molecule extracts suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes

Autor: Constantin Constantinoiu, Luke Becker, Rachael Y. M. Ryan, Paul R. Giacomin, G Buitrago, John J. Miles, Linda Jones, Catherine Shepherd, Konstantinos A. Kouremenos, Alex Loukas, Norelle L. Daly, Phurpa Wangchuk, Malcolm J. McConville

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Here we use a metabolomics approach to characterize the non-protein small molecule complement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c180edc703c4f5fcf041f6bb47a446c
https://doi.org/10.1101/316885

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A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis

Autor: Alex Loukas, Severine Navarro, Catherine Shepherd, Catherine M. Miller, Phurpa Wangchuk, Paul R. Giacomin

Publikováno v: Journal of ethnopharmacology. 211

Ethnopharmacological relevance The traditional uses of Corydalis dubia, Ajania nubigena and Pleurospermum amabile in the Bhutanese traditional medicine for treating disorders related to inflammatory conditions and the in vitro anti-inflammatory activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31d4ead63d9b1311716999940c68cbe
https://pubmed.ncbi.nlm.nih.gov/28942135

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Revisiting the Ancylostoma Caninum Secretome Provides New Information on Hookworm-Host Interactions

Autor: Javier Sotillo, Taylor Morante, Constantin Constantinoiu, Alex Loukas, Catherine Shepherd

Publikováno v: Proteomics. 17(23-24)

Hookworm infection is a major tropical parasitic disease affecting almost 500 million people worldwide. These soil-transmitted helminths can survive for many years in the intestine of the host, where they feed on blood, causing iron deficiency anaemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3127cf4a81696e759b734e2affca133
https://pubmed.ncbi.nlm.nih.gov/29052354

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Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis

Autor: Stephen G. Pyne, Paul A. Keller, Catherine Shepherd, Severine Navarro, Phurpa Wangchuk, Alex Loukas

Publikováno v: Scientific Reports

Aconitum laciniatum is used in Bhutanese traditional medicine for treating various chronic infections and inflammatory conditions. We carried out in-depth isolation and characterization of the phytochemicals from the root component and determined the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfe12f1a496c168b79eb1e003cc25f4

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Identifying the immunomodulatory components of helminths

Autor: David Wilson, Norelle L. Daly, Catherine Shepherd, Alex Loukas, Severine Navarro, Phurpa Wangchuk

Publikováno v: Parasite immunology. 37(6)

Immunomodulatory components of helminths offer great promise as an entirely new class of biologics for the treatment of inflammatory diseases. Here, we discuss the emerging themes in helminth-driven immunomodulation in the context of therapeutic drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69eed61305e2ea5e4755e3e25a3079fc
https://pubmed.ncbi.nlm.nih.gov/25854639

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