Výsledky vyhledávání - "Catherine S, Tripp"

A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis-Relevant Cells and Animal Models

Autor: Julia A. Guzova, Gabriel Mbalaviele, Alexander F. Shaffer, Sheri L. Bonar, John F. Schindler, David C. Thompson, Nandini Kishore, Catherine S. Tripp, Cynthia D. Sommers, Yiding Hu, Sumathy Mathialagan, Po Chang Chiang, Michele A. Melton, Lori Christine

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 329:14-25

Nuclear factor (NF)-kappaB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The central role that IkappaB kinase-2 (IKK-2) plays in regulating NF-kappaB signaling in response to inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88dfc2562c02b4aed4c1440b261119e
https://doi.org/10.1124/jpet.108.143800

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Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides

Autor: Sheri L. Bonar, Adam Libby, Yao Min, Richard Weier, Michael B. Tollefson, Serge G. Wolfson, Michael Clare, Ann M. Donnelly, William E. Mcghee, Dominique Bonafoux, Patrick J. Lennon, Sumathy Mathialagan, Julia A. Guzova, Nandini Kishore, Cindy Sommers, Sharon Rouw, Lori Christine, Catherine S. Tripp

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:2870-2875

A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b9930690fa8fa16c025496d6ce863
https://doi.org/10.1016/j.bmcl.2005.03.090

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Epidermal COX-2 Induction Following Ultraviolet Irradiation: Suggested Mechanism for the Role of COX-2 Inhibition in Photoprotection

Autor: Medora M. Hardy, Kevin S. Chinn, Alice P. Pentland, Peter LaCelle, Catherine S. Tripp, Eric A.G. Blomme

Publikováno v: Journal of Investigative Dermatology. 121:853-861

The cyclooxygenase isoforms, COX-1 and COX-2, are involved in the biosynthesis of prostaglandin E2, a major prostaglandin involved in epidermal homeostasis and repair. Cancer originating in the epidermis can develop when keratinocyte proliferation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6bfa1500da9825ec236e0155eda3fe
https://doi.org/10.1046/j.1523-1747.2003.12495.x

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IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2

Autor: Sumathy Mathialagan, Hymavathi Boddupalli, Q. Khai Huynh, Sharon Rouw, Gary Lange, Troii Hall, David Creely, Rodney G. Combs, Catherine S. Tripp, Ann M. Donnelly, Kuniko Kretzmer, Beverley Reitz, James Caroll, Nandini Kishore

Publikováno v: Journal of Biological Chemistry. 277:13840-13847

NF-kappaB is sequestered in the cytoplasm by the inhibitory IkappaB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IkappaBs leading to their degradation that results in NF-kappaB activation. IKK-1 and IKK-2 are two d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8e2af8226f4a10b1f6807157139c867
https://doi.org/10.1074/jbc.m110474200

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Kinetic Mechanisms of IκB-related Kinases (IKK) Inducible IKK and TBK-1 Differ from IKK-1/IKK-2 Heterodimer

Autor: Q. Khai Huynh, Ann M. Donnelly, Catherine S. Tripp, Sumathy Mathialagan, Nandini Kishore

Publikováno v: Journal of Biological Chemistry. 277:12550-12558

Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkappaB. The phosphorylation of IkappaBalpha on Ser(32) and Ser(36) is initiated by an IkappaB kinase (IKK) complex that includes a catalytic hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1156e5228b5b2cb19e3d221838fb4879
https://doi.org/10.1074/jbc.m111526200

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Characterization of the Recombinant IKK1/IKK2 Heterodimer

Autor: Troii Hall, Catherine S. Tripp, Bryan F. Kilpatrick, Beverly A. Reitz, Carol M. Koboldt, Cindy Sommers, Rodney G. Combs, Hymavathi Boddupalli, Jennifer L. Pierce, Q. Khai Huynh, Sharon A. Rouw, Robin A. Weinberg, Scott D. Hauser, Becky L. Hood, Judy A. Diaz-Collier

Publikováno v: Journal of Biological Chemistry. 275:25883-25891

Nuclear factor kappa B (NF-kappaB) is a ubiquitous, inducible transcription factor that regulates the initiation and progression of immune and inflammatory stress responses. NF-kappaB activation depends on phosphorylation and degradation of its inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22aa869e2c4f4a40e73ba43cbda7da2
https://doi.org/10.1074/jbc.m000296200

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Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist

Autor: Stanley F. Wolf, Emil R. Unanue, Catherine S. Tripp

Publikováno v: Proceedings of the National Academy of Sciences. 90:3725-3729

Listeriosis in mice with the severe combined immunodeficiency (SCID) mutation is an established model in vivo and in vitro of interferon gamma (IFN-gamma)-dependent macrophage activation by natural killer (NK) cells during the development of natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fea7884c44502bb7969735cf74a8e1
https://doi.org/10.1073/pnas.90.8.3725

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Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship

Publikováno v: Bioorganicmedicinal chemistry. 18(1)

Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1beta stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c76055db0ef28806da346227b07a394
https://pubmed.ncbi.nlm.nih.gov/19914076

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Regulation and phenotype of an innate Th1 cell: role of cytokines and the p38 kinase pathway

Autor: Jeffrey J. Yu, John H. Russell, Catherine S. Tripp

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 171(11)

We have explored the phenotype and regulation of Th1 cell activation by the cytokines IL-12 and IL-18. We demonstrate that these two cytokines selectively induce IFN-γ in a differentiated Th1 cell population through the previously described p38 mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e7cb0c18d3e180ede14c960a16f4df
https://pubmed.ncbi.nlm.nih.gov/14634126

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A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

Autor: Khai Huynh, Min Yao, Nandini Kishore, Perry Thao D, Lee Albee, Julia Guzova, Sheri Bonar, Cindy Sommers, Catherine S. Tripp, Sumathy Mathialagan, J. Matthew Graneto, Scott Hauser, Cindy Mielke, Cathleen E. Hanau, Richard M. Weier

Publikováno v: The Journal of biological chemistry. 278(35)

NF-kappa B-induced gene expression contributes significantly to the pathogenesis of inflammatory diseases such as arthritis. I kappa B kinase (IKK) is the converging point for the activation of NF-kappa B by a broad spectrum of inflammatory agonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14886fb69011da098794e503c50f820d
https://pubmed.ncbi.nlm.nih.gov/12813046

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