Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Catherine S, Sprankle"'
Autor:
Kamel Mansouri, Neal F. Cariello, Alexandru Korotcov, Valery Tkachenko, Chris M. Grulke, Catherine S. Sprankle, David Allen, Warren M. Casey, Nicole C. Kleinstreuer, Antony J. Williams
Publikováno v:
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-20 (2019)
Abstract Background The logarithmic acid dissociation constant pKa reflects the ionization of a chemical, which affects lipophilicity, solubility, protein binding, and ability to pass through the plasma membrane. Thus, pKa affects chemical absorption
Externí odkaz:
https://doaj.org/article/4f55baf346f34fe88b0e95561bea6d46
Autor:
Patricia Ceger, Natalia Garcia-Reyero Vinas, David Allen, Elyssa Arnold, Raanan Bloom, Jennifer C. Brennan, Carol Clarke, Karen Eisenreich, Kellie Fay, Jonathan Hamm, Paula F.P. Henry, Katherine Horak, Wesley Hunter, Donna Judkins, Patrice Klein, Nicole Kleinstreuer, Kara Koehrn, Carlie A. LaLone, James P. Laurenson, Jessica K. Leet, Anna Lowit, Scott G. Lynn, Teresa Norberg-King, Edward J. Perkins, Elijah J. Petersen, Barnett A. Rattner, Catherine S. Sprankle, Thomas Steeger, Jim E. Warren, Sarah Winfield, Edward Odenkirchen
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 133
U.S. regulatory and research agencies use ecotoxicity test data to assess the hazards associated with substances that may be released into the environment, including but not limited to industrial chemicals, pharmaceuticals, pesticides, food additives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe062be8b956c9f0b16e97d27bc23cea
https://pubmed.ncbi.nlm.nih.gov/35660046
https://pubmed.ncbi.nlm.nih.gov/35660046
Autor:
Jaleh Abedini, Nicole Kleinstreuer, Ruhi Rai, Eric McAfee, Agnes L. Karmaus, Warren Casey, Patricia Ceger, Isabel Lea, Arpit Tandon, John P. Rooney, Xiaoqing Chang, Catherine S. Sprankle, Kamel Mansouri, David Allen, Shannon M. Bell, Jason Phillips, Bethany Cook
Publikováno v:
Toxicol In Vitro
Moving towards species-relevant chemical safety assessments and away from animal testing requires access to reliable data to develop and build confidence in new approaches. The Integrated Chemical Environment (ICE) provides tools and curated data cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a814796e5b57d8e836477912d61a5a58
https://pubmed.ncbi.nlm.nih.gov/32553663
https://pubmed.ncbi.nlm.nih.gov/32553663
Autor:
Ted W. Simon, Shannon M. Bell, Grazyna Fraczkiewicz, Judy Strickland, M. Bartels, Kim L. R. Brouwer, Annie Lumen, Alicia Paini, Alice Ke, Nisha S. Sipes, Scott G. Lynn, Paul S. Price, Stephen S. Ferguson, Catherine S. Sprankle, Xiaoqing Chang, Annie M. Jarabek, David G. Allen, Nicole Kleinstreuer, Warren Casey, Caroline Ring, John F. Wambaugh, John A. Troutman, Barbara A. Wetmore, Neepa Choksi
Publikováno v:
Toxicol In Vitro
In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18956bd1bb524efb2c658201e1572f05
https://doi.org/10.1016/j.tiv.2017.11.016
https://doi.org/10.1016/j.tiv.2017.11.016
Autor:
Amber B. Daniel, Xiaoqing Chang, David E. Hines, Jaleh Abedini, John P. Rooney, Catherine S. Sprankle, Kamel Mansouri, Bethany Cook, Neepa Choksi, Warren Casey, Agnes L. Karmaus, Shannon M. Bell, Eric McAfee, Jason Phillips, David Allen, Nicole Kleinstreuer
Publikováno v:
Computational Toxicology. 20:100184
New approach methodologies (NAMs) for toxicological applications such as in vitro assays and in silico models generate data that can be useful for assessing potential health impacts of chemicals. The National Toxicology Program’s (NTP’s) Integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d58ff7be8228f7b39eff119135e7af
https://doi.org/10.1016/j.comtox.2021.100184
https://doi.org/10.1016/j.comtox.2021.100184
Autor:
Warren M, Casey, Xiaoqing, Chang, David G, Allen, Patricia C, Ceger, Neepa Y, Choksi, Jui-Hua, Hsieh, Barbara A, Wetmore, Stephen S, Ferguson, Michael J, DeVito, Catherine S, Sprankle, Nicole C, Kleinstreuer
Publikováno v:
Environmental Health Perspectives
Background: To effectively incorporate in vitro data into regulatory use, confidence must be established in the quantitative extrapolation of in vitro activity to relevant end points in animals or humans. Objective: Our goal was to evaluate and optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0addec334164cd75c0738a6a44225a7e
https://pubmed.ncbi.nlm.nih.gov/30192161
https://pubmed.ncbi.nlm.nih.gov/30192161
Autor:
David G. Allen, Stephen S. Ferguson, Neepa Choksi, Warren Casey, Barbara A. Wetmore, Nicole Kleinstreuer, Xiaoqing Chang, Michael J. DeVito, Jui-Hua Hsieh, Catherine S. Sprankle, Patricia Ceger
Publikováno v:
Environmental Health Perspectives. 126
Background: To effectively incorporate in vitro data into regulatory use, confidence must be established in the quantitative extrapolation of in vitro activity to relevant end points in animals or ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcdeee1dc58692a0d93b0bc1627a92a6
https://doi.org/10.1289/ehp1655
https://doi.org/10.1289/ehp1655
Autor:
Warren Casey, Andy Shapiro, Arpit Tandon, Jason Phillips, Alexander Sedykh, Nicole Kleinstreuer, David Allen, Shannon M. Bell, Stephen Q. Morefield, Catherine S. Sprankle, Ruchir R. Shah, Elizabeth A. Maull
Publikováno v:
Environmental Health Perspectives
SUMMARY: Access to high-quality reference data is essential for the development, validation, and implementation of in vitro and in silico approaches that reduce and replace the use of animals in toxicity testing. Currently, these data must often be p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533a4095663fdd3e9dc5057eace505aa
http://europepmc.org/articles/PMC5644972
http://europepmc.org/articles/PMC5644972
Autor:
Vivian W. Doelling, Warren Casey, Sue Nelson, Dorothy Xing, Brett Jones, Jean-Michel Chapsal, William S. Stokes, Christina Bache, Marlies Halder, Catherine S. Sprankle, Lori Rinckel, Richard McFarland, Amélie Castiaux, Angele Costanzo, Richard Isbrucker, Nelson W Johnson, Juan Arciniega, Marieke Hoonakker
Publikováno v:
Biologicals. 42:114-122
Regulatory authorities require safety and potency testing prior to the release of each production lot of acellular pertussis (aP)-containing vaccines. Currently, the murine histamine sensitization test (HIST) is used to evaluate the presence of resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64823bb1795120fddeaa6e05eb344e94
https://doi.org/10.1016/j.biologicals.2013.11.011
https://doi.org/10.1016/j.biologicals.2013.11.011
A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma
Autor:
Mathias Chiano, Michael J. Wagner, Henry M. Sarau, Wayne H. Anderson, Mary E. Fling, Louise Hosking, Peter T. Buckley, Catherine S. Sprankle, Karen M. Kennedy-Wilson, Andrew Green, Dulcie B. Schmidt, William E. Wixted, Ashley A. Barnes, Lee-Ann Cameron, Diane M. Ignar, Sreekumar G. Pillai, Diane Joan Cousens, Jørgen Vestbo, James J. Foley, Malcolm N. Blumenthal
Publikováno v:
Pharmacogenetics. 14:627-633
Cysteinyl leukotrienes (CYSLTR) are potent biological mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and CYSLTR2. The leukotriene modifying agents currently used to control bronchoconstriction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6615a8b29396a21bc2fa5cc09e095a32
https://doi.org/10.1097/00008571-200409000-00007
https://doi.org/10.1097/00008571-200409000-00007