Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

Autor: Christine-Maria Horejs, Jean-Philippe St-Pierre, Juha R. M. Ojala, Joseph A. M. Steele, Patricia Barros da Silva, Angela Rynne-Vidal, Stephanie A. Maynard, Catherine S. Hansel, Clara Rodríguez-Fernández, Manuel M. Mazo, Amanda Y. F. You, Alex J. Wang, Thomas von Erlach, Karl Tryggvason, Manuel López-Cabrera, Molly M. Stevens

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controllin

Externí odkaz: https://doaj.org/article/6f96d69568c34d5fb8957a8cd8f04a9a

Artificial antigen presenting cells for detection and desensitisation of auto-reactive T cells associated with Type 1 diabetes

Autor: Arbel Artzy-Schnirman, Enas Abu-Shah, Rona Chandrawati, Efrat Altman, Norkhairin Yusuf, Shih-Ting Wang, Jose Ramos, Catherine S. Hansel, Maya Haus-Cohen, Rony Dahan, Sefina Arif, Michael L. Dustin, Mark Peakman, Yoram Reiter, Molly M. Stevens

Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668376355fb823a7a98113d810f80d10
http://hdl.handle.net/10044/1/96838

Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery

Autor: Catherine S, Hansel, Spencer W, Crowder, Samuel, Cooper, Sahana, Gopal, Maria, João Pardelha da Cruz, Leonardo, de Oliveira Martins, Debora, Keller, Stephen, Rothery, Michele, Becce, Anthony E G, Cass, Chris, Bakal, Ciro, Chiappini, Molly M, Stevens

Publikováno v: ACS Nano
Hansel, C S, Crowder, S W, Cooper, S, Gopal, S, João Pardelha Da Cruz, M, De Oliveira Martins, L, Keller, D, Rothery, S, Becce, M, Cass, A E G, Bakal, C, Chiappini, C & Stevens, M M 2019, ' Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery ', ACS Nano, vol. 13, no. 3, pp. 2913-2926 . https://doi.org/10.1021/acsnano.8b06998

Biomaterial substrates can be engineered to present topographical signals to cells which, through interactions between the material and active components of the cell membrane, regulate key cellular processes and guide cell fate decisions. However, ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeafbbba4c1eff311afc2fd80b82cbaf

Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells

Autor: Daniela Hühn, Pablo Martí-Rodrigo, Silvana Mouron, Catherine S. Hansel, Kirsten Tschapalda, Bartlomiej Porebski, Maria Häggblad, Louise Lidemalm, Miguel A. Quintela-Fandino, Jordi Carreras-Puigvert, Oscar Fernandez-Capetillo

Estrogen receptor (ER)-positive breast tumors are routinely treated with estrogen-depriving therapies. Despite their effectiveness, patients often progress into a more aggressive form of the disease. Through a chemical screen oriented to identify che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759ef33fcfa706f4d31f83b2569ed57c

Controlled Sub-Nanometer Epitope Spacing in a Three-Dimensional Self-Assembled Peptide Hydrogel

Autor: E. Thomas Pashuck, Molly M. Stevens, Catherine S. Hansel, Benoit Duchet, Lesley W. Chow, Stephanie A. Maynard

Publikováno v: ACS Nano. 10:11096-11104

Cells in the body use a variety of mechanisms to ensure the specificity and efficacy of signal transduction. One way that this is achieved is through tight spatial control over the position of different proteins, signaling sequences, and biomolecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a31725548693d3efc49a4f2ec45ec2
https://doi.org/10.1021/acsnano.6b05975