Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Catherine Ruan"'
Autor:
Jennifer B. Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D’Andrea, Anna P. Hubert, Jake S. Shilan, Wenting Zhou, Adam A. Kraya, Alba Llop Guevara, Catherine Ruan, Violeta Serra, Judith Balmaña, Michael Feldman, Pat J. Morin, Anupma Nayak, Kara N. Maxwell, Susan M. Domchek, Katherine L. Nathanson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Carriers of pathogenic BRCA1/2 variants have a higher risk of breast and ovarian cancers, which recur frequently. Here, the authors sequence primary and recurrent tumours of BRCA1/2 mutation carriers, finding PARP1 amplifications, differential BRCA2
Externí odkaz:
https://doaj.org/article/86e2b8acb27543e9aad8ac4d1b5b8463
Autor:
Violeta Serra, Anna Hubert, Catherine Ruan, Judith Balmaña, Alba Llop-Guevara, Kara N. Maxwell, Susan M. Domchek, Anupma Nayak, Wenting Zhou, John Pluta, Dana Pueschl, Michael Feldman, Katherine L. Nathanson, Adam A. Kraya, Jennifer Shah, Bradley Wubbenhorst, Kurt D.Andrea, Jake S. Shilan
Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). We performed multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa9a298919895f5ce68568b13baf94a
https://doi.org/10.21203/rs.3.rs-745248/v1
https://doi.org/10.21203/rs.3.rs-745248/v1
Autor:
Lauren Schmucker, Bradley Wubbenhorst, Anupma Nayak, Susan M. Domchek, Katherine L. Nathanson, Kurt D'Andrea, John Pluta, Jennifer Shah, Heather Symecko, Kara N. Maxwell, Catherine Ruan, Caitlin Feltcher
Publikováno v:
Cancer Research. 80:2500-2500
Carriers of pathogenic germline mutations in BRCA1/2 are highly predisposed to breast and ovarian cancers. Although their primary tumors respond to DNA-damaging agents, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3efcf835e4a0c614e3f6d83e4e18e36f
https://doi.org/10.1158/1538-7445.am2020-2500
https://doi.org/10.1158/1538-7445.am2020-2500