Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Catherine R. Wasser"'
Autor:
Catherine R. Wasser, Gordon C. Werthmann, Eric M. Hall, Kristina Kuhbandner, Connie H. Wong, Murat S. Durakoglugil, Joachim Herz
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-24 (2023)
Abstract Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling. In the adult brain,
Externí odkaz:
https://doaj.org/article/7a77c3c7cc5e441990b9400990388085
Autor:
Bret M. Evers, Carlos Rodriguez-Navas, Rachel J. Tesla, Janine Prange-Kiel, Catherine R. Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A. Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L. White, III, Joachim Herz
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2565-2574 (2017)
Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with pr
Externí odkaz:
https://doaj.org/article/a8b5570d8446427886cab7bf1d9791a5
Autor:
Catherine R Wasser, Joachim Herz
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 4, Pp 308-310 (2016)
Abstract The earliest clinical manifestation of Alzheimer's disease (AD) is cognitive impairment caused by synaptic dysfunction. ApoE4, the primary risk factor for late‐onset AD, disrupts synaptic homeostasis by impairing synaptic ApoE receptor tra
Externí odkaz:
https://doaj.org/article/1b5fb2ac503840bd8a044d214bfa1197
Autor:
Lea Naestle, Joachim Herz, Xunde Xian, Catherine R. Wasser, Theresa Pohlkamp, Connie H Wong, Courtney Lane-Donovan, Murat S. Durakoglugil, Katja E. Fritschle
Alzheimer’s disease (AD) is a progressive neurodegenerative disease marked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Aβ oligomers cause synaptic dysfunction early in AD by enhancing long-term depression (LTD, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf59c17c1e5382d546a141c35ec94bd
https://mediatum.ub.tum.de/doc/1640036/document.pdf
https://mediatum.ub.tum.de/doc/1640036/document.pdf
Autor:
Janine Prange-Kiel, Rachel Tesla, Catherine R. Wasser, Jeffrey G. McDonald, Gang Yu, Joachim Herz, Kyoung Shin Yoo, Basar Cenik, Charles L. White, Thomas A. Ravenscroft, Rosa Rademakers, Bret M. Evers, Carlos Rodriguez-Navas, Florian Plattner
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2565-2574 (2017)
Cell reports
Cell reports
Summary Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) w
Publikováno v:
The Journal of Physiology. 595:1223-1238
Earlier studies suggest that spontaneous and evoked neurotransmitter release processes are maintained by synaptic vesicles which are segregated into functionally distinct pools. However, direct interrogation of the link between this putative synaptic
Autor:
Joachim Herz, Catherine R. Wasser
Publikováno v:
EMBO Molecular Medicine
Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long‐term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer's disease (AD) risk gene, apoE, ApoER2 has been propos
Publikováno v:
Frontiers in Molecular Neuroscience
The biological fates of the key initiator of Alzheimer's disease (AD), the amyloid precursor protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) receptor-related proteins (LRPs) and their molecular roles in the neu
Autor:
Catherine R. Wasser, Joachim Herz
Publikováno v:
The Journal of biological chemistry. 292(4)
Over half a century ago, D. S. Falconer first reported a mouse with a reeling gate. Four decades later, the Reln gene was isolated and identified as the cause of the reeler phenotype. Initial studies found that loss of Reelin, a large, secreted glyco
Autor:
Catherine R. Wasser, Joachim Herz, Courtney Lane-Donovan, Wen Mai Wong, Shan Jiang, Xunde Xian, Murat S. Durakoglugil
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(39)
Alzheimer's disease (AD) is the most common form of dementia in individuals over the age of 65 years. The most prevalent genetic risk factor for AD is the ε4 allele of apolipoprotein E (ApoE4), and novel AD treatments that target ApoE are being cons