Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Catherine R O'Riordan"'
Autor:
Shelley A. Nass, Maryellen A. Mattingly, Denise A. Woodcock, Brenda L. Burnham, Jeffrey A. Ardinger, Shayla E. Osmond, Amy M. Frederick, Abraham Scaria, Seng H. Cheng, Catherine R. O’Riordan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 33-46 (2018)
The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To d
Externí odkaz:
https://doaj.org/article/c2eeffac7fb04805a98db2eeec81dbf4
Autor:
Laurence M. Occelli, Lena Zobel, Jonathan Stoddard, Johanna Wagner, Nathaniel Pasmanter, Janice Querubin, Lauren M. Renner, Rene Reynaga, Paige A. Winkler, Kelian Sun, Luis Felipe L.P. Marinho, Catherine R. O’Riordan, Amy Frederick, Andreas Lauer, Stephen H. Tsang, William W. Hauswirth, Trevor J. McGill, Martha Neuringer, Stylianos Michalakis, Simon M. Petersen-Jones
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::477ffbc006eb0240ce3eb0682728fa49
https://doi.org/10.1016/j.ymthe.2023.04.005
https://doi.org/10.1016/j.ymthe.2023.04.005
Autor:
He Meng, Marc F Verhagen, Denise Woodcock, Claire A. Davies, Catherine R. O'Riordan, Michelle Sorrentino, Vijender Dhawan
Publikováno v:
Human Gene Therapy. 33:202-212
Gene therapy has evolved over the past decade into a promising therapeutic class for treating many intractable diseases. Recombinant adeno-associated virus (AAV) is the most commonly used viral vector for delivering therapeutic genes. Independent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ac5d74408f69641bb77f2c7c91f082
https://doi.org/10.1089/hum.2021.123
https://doi.org/10.1089/hum.2021.123
Autor:
Sirkka Kyostio-Moore, Patricia Berthelette, Susan Piraino, Cathleen Sookdeo, Bindu Nambiar, Robert Jackson, Brenda Burnham, Catherine R O'Riordan, Seng H Cheng, Donna Armentano
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Recombinant adeno-associated viral (rAAV) vectors containing oversized genomes provide transgene expression despite low efficiency packaging of complete genomes. Here, we characterized the properties of oversized rAAV2/8 vectors (up to 5.4 kb) encodi
Externí odkaz:
https://doaj.org/article/dc83fa3e7b174a09885970c39aa9a954
Publikováno v:
Cell and Gene Therapy Insights. 5:1461-1471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afab3df47789f8a7eb81149c646ba1e3
https://doi.org/10.18609/cgti.2019.154
https://doi.org/10.18609/cgti.2019.154
Autor:
Maryellen Mattingly, Denise Woodcock, Jeffery Ardinger, Shelley Nass, Seng H. Cheng, Brenda Burnham, Catherine R. O'Riordan, Shayla E. Osmond, Amy Frederick, Abraham Scaria
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 33-46 (2018)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd22f17ee71b12e8454dda2fb9b4c48
http://www.sciencedirect.com/science/article/pii/S2329050117301298
http://www.sciencedirect.com/science/article/pii/S2329050117301298
Autor:
Brenda Burnham, Abraham Scaria, Samuel C. Wadsworth, Seng H. Cheng, Denise Woodcock, Catherine R. O'Riordan, Elton Kong, Antonius Song, Maryellen Mattingly, Shelley Nass
Publikováno v:
Human Gene Therapy Methods. 26:228-242
Recombinant adeno-associated viral (rAAV) vectors represent a novel class of biopharmaceutical drugs. The production of clinical-grade rAAV vectors for gene therapy would benefit from analytical methods that are able to monitor drug product quality w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf002dec946618254bc797779f1b04a3
https://doi.org/10.1089/hgtb.2015.048
https://doi.org/10.1089/hgtb.2015.048
Autor:
Lamya S. Shihabuddin, Jie Bu, Seng H. Cheng, Michael Lukason, Abraham Scaria, Jennifer Sullivan, Shayla R Osmond, Catherine R. O'Riordan, Lisa M. Stanek, Elizabeth Barry
Publikováno v:
Gene therapy. 25(3)
The successful application of adeno-associated virus (AAV) gene delivery vectors as a therapeutic paradigm will require efficient gene delivery to the appropriate cells in affected organs. In this study, we utilized a rational design approach to intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd145d305fd4c9cb37240a36df63ff09
https://pubmed.ncbi.nlm.nih.gov/29785047
https://pubmed.ncbi.nlm.nih.gov/29785047
Publikováno v:
Human gene therapy methods. 28(5)
The requirement for robust analytical methods to characterize adeno-associated virus (AAV) vectors is immediate, as the field advances more AAV gene therapies into the clinic and onto commercialization. AAV capsid proteins (VPs) are critical for vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a786df9c5c6e04c5a91533612cf296
https://pubmed.ncbi.nlm.nih.gov/28627251
https://pubmed.ncbi.nlm.nih.gov/28627251
Autor:
Patricia Berthelette, Bindu Nambiar, Donna Armentano, Cathleen Sookdeo, Brenda Burnham, Susan Piraino, Sirkka Kyostio-Moore, Shelley Nass, Karen A. Vincent, Seng H. Cheng, Catherine R. O'Riordan, David W. Souza, Robert B. Jackson
Publikováno v:
Human gene therapy methods. 28(1)
Several ongoing clinical studies are evaluating recombinant adeno-associated virus (rAAV) vectors as gene delivery vehicles for a variety of diseases. However, the production of vectors with genomes >4.7 kb is challenging, with vector preparations fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1e64b78540f6afd300d3eb7e89bf64
https://pubmed.ncbi.nlm.nih.gov/28166648
https://pubmed.ncbi.nlm.nih.gov/28166648