Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Catherine R Cochrane"'
Autor:
Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011290 (2023)
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environm
Externí odkaz:
https://doaj.org/article/a8b2d780e7df44039d495cd700b5e282
Autor:
Sarah J. Byrnes, Thomas A. Angelovich, Kathleen Busman-Sahay, Catherine R. Cochrane, Michael Roche, Jacob D. Estes, Melissa J. Churchill
Publikováno v:
Viruses, Vol 14, Iss 9, p 1997 (2022)
Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with antiretroviral therapy. The pathogenesis of disease is likely multifaceted, with contribution
Externí odkaz:
https://doaj.org/article/7ed0552c021a4568aac3c9f296d8bbf9
Publikováno v:
Cancers, Vol 7, Iss 3, Pp 1554-1585 (2015)
Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms underlying the regulation of CSCs are poorly defined, key developmental
Externí odkaz:
https://doaj.org/article/971ffb1c17d441f1861465e514998334
Autor:
Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C. Guanizo, Gemma S. Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J. Gartner, Trisha A. Jenkins, Paul R. Gorry, Bruce J. Brew, Sharon R. Lewin, Jacob D. Estes, Michael Roche, Melissa J. Churchill
Publikováno v:
Annals of neurology. 92(4)
Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease. However, the size and replication competent nature of the central nervous syste
Autor:
Anette Szczepny, Alvaro Gonzalez-Rajal, Andrew Burgess, W. Samantha N. Jayasekara, Kazu Kikuchi, Vijesh Vaghjiani, Catherine R Cochrane, Geoffrey W. McCaughan, Daniel J. Gough, D. Neil Watkins, Jason E. Cain
Publikováno v:
J Clin Invest
Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic basis of Hh pathway activation in adult solid tumors, such as small-cell lung cancer (SCLC), is unknown. H
Autor:
T B Phung, P Siswara, Alexandra Sexton-Oates, Jordan R. Hansford, Jason E. Cain, S Khan, D McGregor, Anette Szczepny, Elizabeth M. Algar, Catherine R Cochrane, C White, P A Downie
BACKGROUND Medulloblastoma is the most common yet challenging paediatric brain tumour. No longer considered a single disease entity, medulloblastoma is comprised of at least four distinct genetically and molecularly defined subgroups. OBJECTIVES Retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb73f817e98c0f00e1cf50cc4a0bf916
https://europepmc.org/articles/PMC6012945/
https://europepmc.org/articles/PMC6012945/
Publikováno v:
Cancers, Vol 7, Iss 3, Pp 1554-1585 (2015)
Cancers
Cancers
Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms underlying the regulation of CSCs are poorly defined, key developmental
Autor:
Peter Downie, Catherine R Cochrane, Jason E. Cain, D. Neil Watkins, Anette Szczepny, Dean Popovski, W. Samantha N. Jayasekara, Elizabeth M. Algar, David M. Ashley
Publikováno v:
Neuro-Oncology. 19:vi190-vi191
Malignant Rhabdoid Tumor (MRT) is a rare pediatric cancer predominant in the kidney and CNS that is resistant to current treatment regimes. MRT is genetically characterized by homozygous inactivation of SMARCB1, a core subunit of the SWI/SNF chromati
Autor:
Kirstyn T. Carey, Luciano Martelotto, Maya Kansara, Andrew McCaw, Carl R. Walkley, David Thomas, Anette Szczepny, Vijesh Vaghjiani, Catherine R. Cochrane, William Matsui, David N. Watkins, Jason E. Cain
Publikováno v:
Cancer Research. 78:4994-4994
Hedgehog (Hh) signaling regulates patterning, cell-fate and self-renewal in development. Hh proteins signal via Smoothened (Smo), a G-protein coupled receptor whose activity is dependent on translocation to the primary cilium, a single immotile tubul
Autor:
Jason E. Cain, Peter Downie, W. Samantha N. Jayasekara, Catherine R. Cochrane, D. Neil Watkins, Anette Szczepny, Dean Popovski, David M. Ashley, Elizabeth M. Algar
Publikováno v:
Cancer Research. 77:3360-3360
Malignant Rhabdoid Tumor (MRT) is a rare pediatric cancer of the kidney and CNS that is resistant to current treatment protocols. MRT is genetically characterized by homozygous inactivation of SMARCB1, a critical subunit of the SWI/SNF chromatin-remo