Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Catherine Mytilineou"'
Autor:
Jocelyn A. Yabut, Brian C. Kramer, Julie Cheong, Thalia K. Robakis, Catherine Mytilineou, Ruth JnoBaptiste, C. Warren Olanow
Publikováno v:
European Journal of Neuroscience. 19:280-286
The contribution of arachidonic acid (AA) release and metabolism to the toxicity that results from glutathione (GSH) depletion was studied in rat mesencephalic cultures treated with the GSH synthesis inhibitor l-buthionine sulfoximine. Our data show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4cdbc3c195ed75c18694f6262508ed7
https://doi.org/10.1111/j.1460-9568.2004.03111.x
https://doi.org/10.1111/j.1460-9568.2004.03111.x
Publikováno v:
Journal of Neurochemistry. 69:76-83
Neurotrophic factors have been shown to support the survival and promote the recovery of injured neurons both in vivo and in vitro. Here, we investigated whether glial cell line-derived neurotrophic factor (GDNF) and basic fibroblast growth factor (b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1b89cdf3e4560392604fa1f68bd882
https://doi.org/10.1046/j.1471-4159.1997.69010076.x
https://doi.org/10.1046/j.1471-4159.1997.69010076.x
Autor:
Catherine Mytilineou, Efthimia T. Kokotos Leonardi, Pheona M. Radcliffe, Peter Werner, C. Warren Olanow
Publikováno v:
Journal of Neurochemistry. 68:33-39
L-Deprenyl is a relatively selective inhibitor of monoamine oxidase (MAO)-B that delays the emergence of disability and the progression of signs and symptoms of Parkinson's disease. Experimentally, deprenyl has also been shown to prevent neuronal cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2555cb49d689b38c862276b8e3e99c7c
https://doi.org/10.1046/j.1471-4159.1997.68010033.x
https://doi.org/10.1046/j.1471-4159.1997.68010033.x
Autor:
C.W Olanow, Thalia K. Robakis, J Cheong, Ruth JnoBaptiste, Jocelyn A. Yabut, Catherine Mytilineou, Brian C. Kramer
Publikováno v:
Neuroscience. 114:361-372
Glutathione is an important cellular antioxidant present at high concentrations in the brain. We have previously demonstrated that depletion of glutathione in mesencephalic cultures results in cell death and that the presence of glia is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5faea1c3dee401a5d3db8eceb0ea72
https://doi.org/10.1016/s0306-4522(02)00310-x
https://doi.org/10.1016/s0306-4522(02)00310-x
Autor:
C. Warren Olanow, Kevin St. P. McNaught, Peter Jenner, Jocelyn A. Yabut, Catherine Mytilineou, Ruth JnoBaptiste, P. Shashidharan
Publikováno v:
Journal of Neurochemistry. 81:301-306
Mutations in α-synuclein, parkin and ubiquitin C-terminal hydrolase L1, and defects in 26/20S proteasomes, cause or are associated with the development of familial and sporadic Parkinson's disease (PD). This suggests that failure of the ubiquitin–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed23227d3d6d52cfb618288d1ab18ac
https://doi.org/10.1046/j.1471-4159.2002.00821.x
https://doi.org/10.1046/j.1471-4159.2002.00821.x
Autor:
Brian C. Kramer, Efthimia T. Kokotos Leonardi, C. Warren Olanow, Tejal Jamindar, Catherine Mytilineou
Publikováno v:
Journal of Neurochemistry. 73:112-119
We have examined the role of glial cells in the toxicity that results from inhibition of reduced glutathione (GSH) synthesis by L-buthionine sulfoximine (BSO) in mesencephalic cell cultures. We show that GSH depletion, to levels that cause total cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e283a7ff84b3d7a17b30faa137de52
https://doi.org/10.1046/j.1471-4159.1999.0730112.x
https://doi.org/10.1046/j.1471-4159.1999.0730112.x
Publikováno v:
Brain Research. 851:221-227
Glial cell line derived neurotrophic factor (GDNF) has been shown to be a potent neurotrophic factor for dopamine neurons in culture and to prevent the loss of substantia nigra dopamine neurons following in vivo lesions with 6-hydroxydopamine (6-OHDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13beb790111c695fb69220508f794bb6
https://doi.org/10.1016/s0006-8993(99)02191-5
https://doi.org/10.1016/s0006-8993(99)02191-5
Publikováno v:
European Journal of Pharmacology. 263:157-162
The effect of 3,4-dihydroxyphenylalanine (L-dopa) treatment on the ability of intact human cells to metabolize substrates for mitochondrial oxidative phosphorylation was studied in embryonic fibroblasts. Treatment with L-dopa (100-400 microM) for 48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a82a5fb68c686643e5cc6e991f872e
https://doi.org/10.1016/0014-2999(94)90536-3
https://doi.org/10.1016/0014-2999(94)90536-3
Publikováno v:
Journal of Neurochemistry. 68:434-436
Selegiline [L-(-)-deprenyl], a monoamine oxidase B inhibitor, has been used in the treatment of Parkinson's disease as a putative neuroprotective agent. Selegiline is metabolized rapidly in the gastrointestinal tract and liver to desmethylselegiline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051fc21b0e4ca8cfcd9b24f8da19534f
https://doi.org/10.1046/j.1471-4159.1997.68010434.x
https://doi.org/10.1046/j.1471-4159.1997.68010434.x
Publikováno v:
Parkinsonism & Related Disorders. 8:385-387
Oxidative stress is believed to contribute to the pathogenesis of Parkinson's disease. One of the indices of oxidative stress is the depletion of the antioxidant glutathione (GSH), which may occur early in the development of Parkinson's disease. To s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5143a208c4f1bc7c3eb52989d56a14
https://doi.org/10.1016/s1353-8020(02)00018-4
https://doi.org/10.1016/s1353-8020(02)00018-4