Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Catherine Manser"'
Autor:
Florence Guillot, Catherine Manser, Jennifer Davies, Alessio Vagnoni, Christopher C.J. Miller
Publikováno v:
Journal of Neurochemistry. 121:343-348
Cyclin-dependent kinase-5 (cdk5)/p35 and protein phosphatase-1 (PP1) are two major enzymes that control a variety of physiological processes within the nervous system including neuronal differentiation, synaptic plasticity and axonal transport. Defec
Publikováno v:
Journal of Cell Science
Journal of Cell Science; Vol 124
Journal of Cell Science; Vol 124
Kinesin light chain 1 (KLC1) binds to the intracellular cytoplasmic domain of the type-1 membrane-spanning protein calsyntenin-1 (also known as alcadein-α) to mediate transport of a subset of vesicles. Here, we identify serine 460 in KLC1 (KLC1ser46
Autor:
Kurt J. De Vos, Andrew J. Grierson, Christopher C.J. Miller, Roy Milner, Jonathan D. Wood, Ellen J. Bennett, Paul R. Kasher, Stephen B. Wharton, Megan Bingley, Catherine Manser, Pamela J. Shaw, Christopher J McDermott
Publikováno v:
Journal of Neurochemistry. 110:34-44
Mutations in spastin are the most common cause of hereditary spastic paraplegia (HSP) but the mechanisms by which mutant spastin induces disease are not clear. Spastin functions to regulate microtubule organisation, and because of the essential role
Autor:
Alison Stevenson, Declan M. McLoughlin, Kurt J. De Vos, P. Nigel Leigh, Darran Yates, Alessio Vagnoni, Catherine Manser, Christopher C.J. Miller
Publikováno v:
Neuroscience Letters. 454:161-164
Riluzole is the only drug approved for the treatment of amyotrophic lateral sclerosis (ALS) but its precise mode of action is not properly understood. Damage to axonal transport of neurofilaments is believed to be part of the pathogenic mechanism in
Autor:
P. Nigel Leigh, Christopher Shaw, Catherine Manser, Christopher C.J. Miller, Kurt J. De Vos, Andrew J. Grierson, Pamela J. Shaw, Janet Brownlees, Declan M. McLoughlin, Anna L. Chapman, Elizabeth L. Tudor, Kwok-Fai Lau, Maria E. Tennant, Steven Ackerley
Publikováno v:
Human Molecular Genetics. 16:2720-2728
PUBLISHED
Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce disease are not
Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce disease are not
Autor:
Emma L. Scotter, Agnes L. Nishimura, Mike Dragunow, Caroline Vance, Hazel Urwin, Boris Rogelj, Tibor Hortobágyi, Christopher Shaw, Christopher C.J. Miller, Claire Troakes, Claudia Kathe, Catherine Manser, Jacqueline C. Mitchell
Publikováno v:
Human Molecular Genetics
Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing. Large FUS-immunoreact
Autor:
Catherine, Manser, Alessio, Vagnoni, Florence, Guillot, Jennifer, Davies, Christopher C J, Miller
Publikováno v:
Journal of neurochemistry. 121(3)
Cyclin-dependent kinase-5 (cdk5)/p35 and protein phosphatase-1 (PP1) are two major enzymes that control a variety of physiological processes within the nervous system including neuronal differentiation, synaptic plasticity and axonal transport. Defec
Autor:
Florence Guillot, Alessio Vagnoni, Jennifer Davies, Kwok-Fai Lau, Catherine Manser, K.J. De Vos, Christopher C.J. Miller, Declan M. McLoughlin
Publikováno v:
Manser, C, Guillot, F, Vagnoni, A, Davies, J, Lau, K-F, McLoughlin, D M, De Vos, K J & Miller, C C J 2012, ' Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo ', Oncogene, vol. 31, no. 22, pp. 2773-2782 . https://doi.org/10.1038/onc.2011.437
A recent genome-wide association study identified the gene encoding lemur tyrosine kinase-2 (LMTK2) as a susceptibility gene for prostate cancer. The identified genetic alteration is within intron 9, but the mechanisms by which LMTK2 may impact upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049c8157aabebe396c6a31f237c0e984
Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments
Autor:
Darran Yates, Christopher Shaw, Declan M. McLoughlin, Catherine Manser, Kurt J. De Vos, Christopher C.J. Miller
Publikováno v:
European journal of cell biology. 88(4)
Neurofilaments are the intermediate filaments of neurons and are synthesised in neuronal cell bodies and then transported through axons. Neurofilament light chain (NFL) is a principal component of neurofilaments, and phosphorylation of NFL head domai
Autor:
Christopher C.J. Miller, Christopher Shaw, Alison Stevenson, Jennifer Davies, Catherine Manser, Yoshitaka Ono, Declan M. McLoughlin, P. Nigel Leigh, Elizabeth L. Tudor, Steven J. Banner
Publikováno v:
FEBS letters. 582(15)
Neurofilaments are synthesised in neuronal cell bodies and then transported through axons. Damage to neurofilament transport is seen in amyotrophic lateral sclerosis (ALS). Here, we show that PKN1, a neurofilament head–rod domain kinase is cleaved