Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Catherine M. O'Connell"'
Autor:
Chuwen Liu, Neha Vivek Mokashi, Toni Darville, Xuejun Sun, Catherine M. O’Connell, Katrin Hufnagel, Tim Waterboer, Xiaojing Zheng
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT We developed a reusable and open-source machine learning (ML) pipeline that can provide an analytical framework for rigorous biomarker discovery. We implemented the ML pipeline to determine the predictive potential of clinical and immunoprot
Externí odkaz:
https://doaj.org/article/a20bcfbc90f0459891d75c011cae1631
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Chlamydia trachomatis infection of ocular conjunctiva can lead to blindness, while infection of the female genital tract can lead to chronic pelvic pain, ectopic pregnancy, and/or infertility. Conjunctival and fallopian tube inflammation and the resu
Externí odkaz:
https://doaj.org/article/49698dabf11946728268f2e13d5370ba
Autor:
Wujuan Zhong, Avinash Kollipara, Yutong Liu, Yuhan Wang, Catherine M. O’Connell, Taylor B. Poston, Kacy Yount, Harold C. Wiesenfeld, Sharon L. Hillier, Yun Li, Toni Darville, Xiaojing Zheng
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectivesIdentify genetic loci of enhanced susceptibility to Chlamydial trachomatis (Ct) upper genital tract infection in women.MethodsWe performed an integrated analysis of DNA genotypes and blood-derived mRNA profiles from 200 Ct-exposed women to
Externí odkaz:
https://doaj.org/article/6c8270e983b4469a8c83442361dd6984
Autor:
Catherine M. O’Connell, Hayden Brochu, Jenna Girardi, Erin Harrell, Aiden Jones, Toni Darville, Arlene C. Seña, Xinxia Peng
Publikováno v:
Microbial Cell, Vol 6, Iss 3, Pp 177-183 (2019)
Pelvic inflammatory disease (PID) is a female upper genital tract inflammatory disorder that arises after sexually transmitted bacterial infections (STI). Factors modulating risk for reproductive sequelae include co-infection, microbiota, host geneti
Externí odkaz:
https://doaj.org/article/876bcf6ffadc4daab4bbb01a26eeb090
Publikováno v:
Microbial Cell, Vol 3, Iss 9, Pp 390-403 (2016)
Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes trachoma in endemic areas, mostly Africa and the Middle East, and is a l
Externí odkaz:
https://doaj.org/article/891731bc92d54d3ab7ed98f9987b00e7
Autor:
Amanda F. Amaral, Khondaker S. Rahman, Andrew R. Kick, Lizette M. Cortes, James Robertson, Bernhard Kaltenboeck, Volker Gerdts, Catherine M. O’Connell, Taylor B. Poston, Xiaojing Zheng, Chuwen Liu, Sam Y. Omesi, Toni Darville, Tobias Käser
Publikováno v:
Vaccines, Vol 8, Iss 3, p 353 (2020)
Chlamydia trachomatis (Ct) infections are the most frequent bacterial sexually transmitted disease, and they can lead to ectopic pregnancy and infertility. Despite these detrimental long-term sequelae, a vaccine is not available. Success in preclinic
Externí odkaz:
https://doaj.org/article/3353fe0cafa540d584677c353922d06a
Autor:
Xiaojing Zheng, Catherine M. O'Connell, Wujuan Zhong, Taylor B. Poston, Harold C. Wiesenfeld, Sharon L. Hillier, Maria Trent, Charlotte Gaydos, George Tseng, Brandie D. Taylor, Toni Darville
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment increases r
Externí odkaz:
https://doaj.org/article/7929087bf0ed4c788a6c7611f0c358d0
Autor:
K. Shamsur Rahman, Toni Darville, Ali N. Russell, Catherine M. O’Connell, Harold C. Wiesenfeld, Sharon L. Hillier, Erfan U. Chowdhury, Yen-Chen Juan, Bernhard Kaltenboeck
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Chlamydia species-specific serology is compromised by cross-reactivity of the gold standard microimmunofluorescence (MIF) or commercial enzyme-linked immunosorbent assays (ELISAs). This study was conducted to discover novel C. trachomatis-sp
Externí odkaz:
https://doaj.org/article/06a7cc56bcb04dc2bc9cd3db122d9228
Autor:
K. Shamsur Rahman, Toni Darville, Ali N. Russell, Catherine M. O'Connell, Harold C. Wiesenfeld, Sharon L. Hillier, De’Ashia E. Lee, Bernhard Kaltenboeck
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Sensitive species-specific detection of anti-Chlamydia trachomatis antibodies is compromised by cross-reactivity of the C. trachomatis antigens used in standard microimmunofluorescence (MIF) testing and enzyme-linked immunosorbent assays (EL
Externí odkaz:
https://doaj.org/article/a9bc7f85745a46fb8e5ccf351a19a22d
Publikováno v:
Infection and Immunity. 91
Chlamydia trachomatis is the most common cause of infectious blindness and sexually transmitted bacterial infection globally. C. trachomatis contains a conserved chlamydial plasmid with eight coding sequences. Plasmid-cured Chlamydia strains are atte