Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma

Autor: Catherine M. Mills, Jonathan Turner, Ivett C. Piña, Kathleen A. Garrabrant, Dirk Geerts, André S. Bachmann, Yuri K. Peterson, Patrick M. Woster

Publikováno v: European Journal of Medicinal Chemistry, 244:114818. Elsevier Masson SAS
Mills, C M, Turner, J, Piña, I C, Garrabrant, K A, Geerts, D, Bachmann, A S, Peterson, Y K & Woster, P M 2022, ' Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma ', European Journal of Medicinal Chemistry, vol. 244, 114818 . https://doi.org/10.1016/j.ejmech.2022.114818

The epigenetic regulator lysine specific demethylase 1 (LSD1), a MYCN cofactor, cooperatively silences MYCN suppressor genes. Furthermore, LSD1 has been correlated with adverse effects in neuroblastic tumors by propagating an undifferentiated, malign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6976025fd1feb3d3b098d8d697b480d
https://research.vumc.nl/en/publications/ebe1ebb1-a907-4adb-868e-f0f0d3a2cfba

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Autor: Carsten Krieg, Yiping Yang, Catherine M. Mills, Bei Liu, Daniel T. Gewirth, Zihai Li, Amy H. Wahlquist, Shaoli Sun, Anqi Li, John D. Huck, Saleh Rachidi, Silvia Guglietta, David P. Carbone, Bill X. Wu, Alessandra Metelli, Mark P. Rubinstein, Michael B. Lilly, Brian Riesenberg

Publikováno v: Sci Transl Med

Cancer-associated thrombocytosis and high concentrations of circulating transforming growth factor-β1 (TGF-β1) are frequently observed in patients with progressive cancers. Using genetic and pharmacological approaches, we show a direct link between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6397d257bc059bead16e5bdfcecc66
https://pubmed.ncbi.nlm.nih.gov/31915300

The Efficacy and Clinical Impact of Brain Imaging in Neurologically Symptomatic AIDS Patients

Autor: Robert M. Levy, Catherine M. Mills, Jonathan P. Posin, Sheila G. Moore, Mark L. Rosenblum, Dale E. Bredesen

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 3:461

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e4ccf9ab8150245e75f5e9231aa4af8
https://doi.org/10.1097/00126334-199005000-00001

Nuclear magnetic resonance imaging in multiple sclerosis

Autor: Leon Kaufman, David Norman, Catherine M. Mills, Michael J. Aminoff, Lawrence E. Crooks, Steven A. Lukes, Hillel S. Panitch

Publikováno v: Annals of Neurology. 13:592-601

Ten patients with definite multiple sclerosis underwent hydrogen nuclear magnetic resonance imaging with a 3.5 kilogauss superconducting magnet, using the inversion recovery and spin-echo techniques of signal acquisition. Results were compared with h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9cb5a3f787588d58ae1ec666353b56
https://doi.org/10.1002/ana.410130603

MRI of the knee in diffuse pigmented villonodular synovitis

Autor: Harry K. Genant, Clyde A. Helms, David W. Stoller, John V. Crues, Lynne S. Steinbach, Joel K. Lipman, Christian H. Neumann, Catherine M. Mills

Publikováno v: Clinical imaging. 13(4)

Magnetic resonance imaging (MRI) was performed on 11 patients with surgically proven pigmented villonodular synovitis (PVNS) of the knee. PVNS was diagnosed on the basis of presence of hemosiderin, joint effusion, and hyperplastic synovium without si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce120e2f3eae8a1d1b45bf6712610524
https://pubmed.ncbi.nlm.nih.gov/2598113