Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Catherine M. Meis"'
Autor:
Rayhan A. Lal, Caitlin L. Maikawa, Dana Lewis, Sam W. Baker, Anton A. A. Smith, Gillie A. Roth, Emily C. Gale, Lyndsay M. Stapleton, Joseph L. Mann, Anthony C. Yu, Santiago Correa, Abigail K. Grosskopf, Celine S. Liong, Catherine M. Meis, Doreen Chan, Joseph P. Garner, David M. Maahs, Bruce A. Buckingham, Eric A. Appel
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)
Abstract Understanding how automated insulin delivery (AID) algorithm features impact glucose control under full closed loop delivery represents a critical step toward reducing patient burden by eliminating the need for carbohydrate entries at mealti
Externí odkaz:
https://doaj.org/article/b08f806168ca4c878812280d3471a23a
Autor:
Joseph L. Mann, Catherine M. Meis, Abigail K. Grosskopf, Eric A. Appel, Erika E Salzman, Caitlin L. Maikawa, Anton A. A. Smith
Publikováno v:
ACS Biomaterials Science & Engineering
Biotherapeutics currently dominate the landscape of new drugs because of their exceptional potency and selectivity. Yet, the intricate molecular structures that give rise to these beneficial qualities also render them unstable in formulation. Hydroge
Autor:
Anton A. A. Smith, Abigail K. Grosskopf, Eric A. Appel, Gillie A. Roth, Santiago Correa, Doreen Chan, Sam W. Baker, David M. Maahs, Caitlin L. Maikawa, Celine Liong, Bruce A. Buckingham, Lyndsay M. Stapleton, Joseph L. Mann, Catherine M. Meis, Megan L. Troxell, Lei Zou, Emily C. Gale, Matthew J. Webber, Anthony C. Yu
Publikováno v:
Maikawa, C L, Smith, A A A, Zou, L, Roth, G A, Gale, E C, Stapleton, L M, Baker, S W, Mann, J L, Yu, A C, Correa, S, Grosskopf, A K, Liong, C S, Meis, C M, Chan, D, Troxell, M, Maahs, D M, Buckingham, B A, Webber, M J & Appel, E A 2020, ' A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs ', Nature Biomedical Engineering, vol. 4, no. 5, pp. 507-517 . https://doi.org/10.1038/s41551-020-0555-4
Nature biomedical engineering
Nature biomedical engineering
Treatment of patients with diabetes with insulin and pramlintide (an amylin analogue) is more effective than treatment with insulin only. However, because mixtures of insulin and pramlintide are unstable and have to be injected separately, amylin ana
Autor:
Catherine M. Meis, Ben S. Ou, Abigail K. Grosskopf, David M. Maahs, Anton A. A. Autzen, Eric A. Appel, Caitlin L. Maikawa, Joseph L. Mann, Aadithya Kannan, Gerald G. Fuller
Publikováno v:
Biomacromolecules
There are 150 million people with diabetes worldwide who require insulin replacement therapy, and the prevalence of diabetes is rising the fastest in middle- and low-income countries. The current formulations require costly refrigerated transport and
Autor:
Ben S. Ou, Anton A. A. Smith, Caitlin L. Maikawa, David M. Maahs, Eric A. Appel, Aadithya Kannan, Catherine M. Meis, Gerald G. Fuller, Joseph L. Mann
There are 150 million people with diabetes worldwide who require insulin replacement therapy and the prevalence of diabetes is rising fastest in middle and low-income countries. Current formulations require costly refrigerated transport and storage t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3bf92781ba01cd64b474b90c21a3e3d
https://doi.org/10.1101/2021.04.13.439582
https://doi.org/10.1101/2021.04.13.439582
Publikováno v:
Journal of visualized experiments : JoVE
These methods describe how to formulate injectable, supramolecular polymer-nanoparticle (PNP) hydrogels for use as biomaterials. PNP hydrogels are composed of two components: hydrophobically modified cellulose as the network polymer and self-assemble
Autor:
Gillie A. Roth, Abigail K. Grosskopf, Catherine M. Meis, Sam W. Baker, Eric A. Appel, Joseph L. Mann, Doreen Chan, Lyndsay M. Stapleton, Almar Postma, Ben Muir, Anthony C. Yu, Shaun C. Howard, Caitlin L. Maikawa, Anton A. A. Smith, Celine Liong, Santiago Correa, Emily C. Gale
Publikováno v:
Mann, J L, Maikawa, C L, Smith, A A A, Grosskopf, A K, Baker, S W, Roth, G A, Meis, C M, Gale, E C, Liong, C S, Correa, S, Chan, D, Stapleton, L M, Yu, A C, Muir, B, Howard, S, Postma, A & Appel, E A 2020, ' An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients ', Science Translational Medicine, vol. 12, no. 550, eaba6676 . https://doi.org/10.1126/scitranslmed.aba6676
Insulin has been used to treat diabetes for almost 100 years; yet, current rapid-acting insulin formulations do not have sufficiently fast pharmacokinetics to maintain tight glycemic control at mealtimes. Dissociation of the insulin hexamer, the prim
Autor:
Anton A. A. Smith, Joseph L. Mann, Caitlin L. Maikawa, Lei Zou, Eric A. Appel, Matthew J. Webber, Catherine M. Meis
Publikováno v:
Adv Ther (Weinh)
Maikawa, C L, Smith, A A A, Zou, L, Meis, C M, Mann, J L, Webber, M J & Appel, E A 2020, ' Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues ', Advanced Therapeutics, vol. 3, no. 1, 1900094 . https://doi.org/10.1002/adtp.201900094
Maikawa, C L, Smith, A A A, Zou, L, Meis, C M, Mann, J L, Webber, M J & Appel, E A 2020, ' Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues ', Advanced Therapeutics, vol. 3, no. 1, 1900094 . https://doi.org/10.1002/adtp.201900094
Current "fast-acting" insulin analogues contain amino acid modifications meant to inhibit dimer formation and shift the equilibrium of association states toward the monomeric state. However, the insulin monomer is highly unstable and current formulat
Publikováno v:
Analytical Methods. 7:10217-10223
On-chip sample processing is integral to the continued development of lab-on-a-chip devices for various applications. An active microfluidic mixer prototype is proposed using ionic electroactive polymer actuators (IEAPAs) as artificial cilia. A proof
Publikováno v:
Sensors and Actuators B: Chemical. 205:371-376
Functional ionomeric polymer membranes are the backbone of a wide range of ionic devices; the mobility of ions through the ionomeric membrane is the principle of operation of these devices. Drift and diffusion of ions through ionomeric membranes stro