Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Catherine M. Kopil"'
Autor:
Lana M. Chahine, Naomi Louie, J Solle, Fulya Akçimen, Andrew Ameri, Samantha Augenbraun, Sabrina Avripas, Sarah Breaux, Christopher Causey, Shivika Chandra, Marissa Dean, Elizabeth A. Disbrow, Lauren Fanty, Jessica Fernandez, Erin R. Foster, Erin Furr Stimming, Deborah Hall, Vanessa Hinson, Ashani Johnson-Turbes, Cabell Jonas, Camilla Kilbane, Scott A. Norris, Bao-Tran Nguyen, Mahesh Padmanaban, Kimberly Paquette, Carly Parry, Natalia Pessoa Rocha, Ashley Rawls, Ejaz A. Shamim, Lisa M. Shulman, Rebeka Sipma, Julia Staisch, Rami Traurig, Rainer von Coelln, Peter Wild Crea, Tao Xie, Zih-Hua Fang, Alyssa O’Grady, Catherine M. Kopil, Maggie McGuire Kuhl, Andrew Singleton, Cornelis Blauwendraat, Sara Bandres-Ciga, the BLAAC PD Study and the Global Parkinson’s Genetics Program (GP2)
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Determining the genetic contributions to Parkinson’s disease (PD) across diverse ancestries is a high priority as this work can guide therapeutic development in a global setting. The genetics of PD spans the etiological risk spectrum, from
Externí odkaz:
https://doaj.org/article/15c7bceb54b1476f84c1fdcc646a1eef
Autor:
Tien Dam, Gennaro Pagano, Michael C. Brumm, Caroline Gochanour, Kathleen L. Poston, Daniel Weintraub, Lana M. Chahine, Christopher Coffey, Caroline M. Tanner, Catherine M. Kopil, Yuge Xiao, Sohini Chowdhury, Luis Concha-Marambio, Peter DiBiaso, Tatiana Foroud, Mark Frasier, Danna Jennings, Karl Kieburtz, Kalpana Merchant, Brit Mollenhauer, Thomas J. Montine, Kelly Nudelman, John Seibyl, Todd Sherer, Andrew Singleton, Diane Stephenson, Matthew Stern, Claudio Soto, Eduardo Tolosa, Andrew Siderowf, Billy Dunn, Tanya Simuni, Kenneth Marek, the Parkinson’s Progression Markers Initiative
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The Neuronal alpha-Synuclein Disease (NSD) biological definition and Integrated Staging System (NSD-ISS) provide a research framework to identify individuals with Lewy body pathology and stage them based on underlying biology and increasing
Externí odkaz:
https://doaj.org/article/bcf123a33df949f9999736ef3c3dd94e
Autor:
Tiago A. Mestre, Glenn T. Stebbins, Diane Stephenson, David Dexter, Karen K. Lee, Yuge Xiao, Tien Dam, Catherine M. Kopil, Tanya Simuni
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-7 (2024)
Novel therapies with the ability to delay disease progression are a gap in the care of people living with Parkinson disease (PD) today. Clinical outcomes assessments (COAs) that are sensitive to the earliest clinical changes in PD are deemed essentia
Externí odkaz:
https://doaj.org/article/2c5e431a2f144bc9818065772b6b9d07
Autor:
Sneha Mantri, Madeline Lepore, Briana Edison, Margaret Daeschler, Catherine M. Kopil, Connie Marras, Lana M. Chahine
Publikováno v:
Journal of Patient-Centered Research and Reviews, Vol 8, Iss 3, Pp 232-238 (2021)
Purpose: Wearing off of Parkinson’s disease medication is common, but triggers and coping strategies for this transient phenomenon are poorly understood. We aimed to assess the lived experience of OFF periods for people with Parkinson’s disease.
Externí odkaz:
https://doaj.org/article/0f69f74f97aa469c83d2d02df3dd5fc8
Autor:
Ruth B. Schneider, Larsson Omberg, Eric A. Macklin, Margaret Daeschler, Lauren Bataille, Shalini Anthwal, Taylor L. Myers, Elizabeth Baloga, Sidney Duquette, Phil Snyder, Katherine Amodeo, Christopher G Tarolli, Jamie L. Adams, Katherine F Callahan, Joshua Gottesman, Catherine M. Kopil, Codrin Lungu, Alberto Ascherio, James C. Beck, Kevin Biglan, Alberto J. Espay, Caroline Tanner, David Oakes, Ira Shoulson, Dan Novak, Elise Kayson, Earl Ray Dorsey, Lara Mangravite, Michael A. Schwarzschild, Tanya Simuni, the Parkinson Study Group AT‐HOME PD Investigators
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 2, Pp 308-320 (2021)
Abstract Objective The expanding power and accessibility of personal technology provide an opportunity to reduce burdens and costs of traditional clinical site‐centric therapeutic trials in Parkinson’s disease and generate novel insights. The val
Externí odkaz:
https://doaj.org/article/7feb687f3d094d1c9e817ead9428641d
Autor:
Luba Smolensky, Ninad Amondikar, Karen Crawford, Scott Neu, Catherine M. Kopil, Margaret Daeschler, Lindsey Riley, andMe Research Team, Ethan Brown, Arthur W. Toga, Caroline Tanner
Publikováno v:
Scientific Data, Vol 7, Iss 1, Pp 1-9 (2020)
Measurement(s) Parkinson’s disease • Patient Reported Outcome • SNP Technology Type(s) questionnaire • crowd sourced data generation • single-nucleotide polymorphism analysis Factor Type(s) cohort • data acquisition source • temporal in
Externí odkaz:
https://doaj.org/article/c589009ea61b485b9ac8c33f91aa79c4
Autor:
Akiva S. Cohen, Shanti R. Tummala, David M. Gullotti, Catherine M. Kopil, Barclay Morrison, Samuel A Gorka, David F. Meaney, Cameron R. Bass, Ted Abel, Matthew Beamer
Blast-induced traumatic brain injury (bTBI) and its long term consequences are a major health concern among veterans. Despite recent work enhancing our knowledge about bTBI, very little is known about the contribution of the blast wave alone to the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c40ab12e656f975428e40d1dad967ae
https://europepmc.org/articles/PMC5062598/
https://europepmc.org/articles/PMC5062598/
Publikováno v:
Journal of Neurochemistry. 123:147-158
Disruption of neuronal Ca(2+) homeostasis plays a well-established role in cell death in a number of neurodegenerative disorders. Recent evidence suggests that proteolysis of the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), a Ca(2+) rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2378f83cd63501adc3ccabd63cd6f1d8
https://doi.org/10.1111/j.1471-4159.2012.07859.x
https://doi.org/10.1111/j.1471-4159.2012.07859.x
Autor:
Catherine M. Kopil, Horia Vais, Robert W. Neumar, J. Kevin Foskett, Don On Daniel Mak, King-Ho Cheung, Adam P. Siebert
Publikováno v:
Journal of Biological Chemistry. 286:35998-36010
The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a ubiquitous intracellular Ca(2+) release channel that is vital to intracellular Ca(2+) signaling. InsP(3)R1 is a proteolytic target of calpain, which cleaves the channel to form a 95-kD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5a9abc976b6ffe8dffb29f2cfaf41f
https://doi.org/10.1074/jbc.m111.254177
https://doi.org/10.1074/jbc.m111.254177
Publikováno v:
Critical Care Medicine. 39:1423-1430
Post-cardiac-arrest therapeutic hypothermia improves outcomes in comatose cardiac arrest survivors. This study tests the hypothesis that the efficacy of post-cardiac-arrest therapeutic hypothermia is dependent on the onset and duration of therapy.Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c793e1648b611f018bf3b5631ee7f590
https://doi.org/10.1097/ccm.0b013e318212020a
https://doi.org/10.1097/ccm.0b013e318212020a