Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Catherine M. Evans"'
Autor:
Arnulf Hertweck, Catherine M. Evans, Malihe Eskandarpour, Jonathan C.H. Lau, Kristine Oleinika, Ian Jackson, Audrey Kelly, John Ambrose, Peter Adamson, David J. Cousins, Paul Lavender, Virginia L. Calder, Graham M. Lord, Richard G. Jenner
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2756-2770 (2016)
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment
Externí odkaz:
https://doaj.org/article/62e0042e1c2743aca84f38295c4cab13
Publikováno v:
Annals of the Rheumatic Diseases. 74:294-302
ObjectiveTo investigate whether regulatory T cells (Treg) can control B cell function in rheumatoid arthritis (RA) and if not to explore the basis for this defect.MethodsSuppression of B cell responses by Treg was analysed in vitro by flow cytometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073d80904978408da763ba624cb200ce
https://doi.org/10.1136/annrheumdis-2013-204049
https://doi.org/10.1136/annrheumdis-2013-204049
Autor:
Richard G. Jenner, Catherine M Evans
Publikováno v:
Briefings in Functional Genomics
The differentiation of CD4 helper T cells into specialized effector lineages has provided a powerful model for understanding immune cell differentiation. Distinct lineages have been defined by differential expression of signature cytokines and the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbeddf45b34c9fcae8395bd4c52fe62
http://europepmc.org/articles/PMC3838196
http://europepmc.org/articles/PMC3838196
Autor:
Rosemary E. Gale, Lu Zhao, Robert Kerrin Hills, Alan Kenneth Burnett, David C. Linch, Claire Green, Catherine M Evans
Publikováno v:
Blood. 118:409-412
We have investigated the prognostic significance of isocitrate dehydrogenase 2 (IDH2) mutations in 1473 younger adult acute myeloid leukemia patients treated in 2 United Kingdom Medical Research Council trials. An IDH2 mutation was present in 148 cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b57bb85644d192350a680b43080719d
https://doi.org/10.1182/blood-2010-12-322479
https://doi.org/10.1182/blood-2010-12-322479
Autor:
Catherine M Evans, Rosemary E. Gale, Alan Kenneth Burnett, David C. Linch, Claire Green, Robert Kerrin Hills
Publikováno v:
Blood. 116:2779-2782
Mutations in the isocitrate dehydrogenase gene (IDH1) were recently described in patients with acute myeloid leukemia (AML). To investigate their prognostic significance we determined IDH1 status in 1333 young adult patients, excluding acute promyelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5beba565424de191b01d933e1e5b370
https://doi.org/10.1182/blood-2010-02-270926
https://doi.org/10.1182/blood-2010-02-270926
Autor:
Arnulf, Hertweck, Catherine M, Evans, Malihe, Eskandarpour, Jonathan C H, Lau, Kristine, Oleinika, Ian, Jackson, Audrey, Kelly, John, Ambrose, Peter, Adamson, David J, Cousins, Paul, Lavender, Virginia L, Calder, Graham M, Lord, Richard G, Jenner
Publikováno v:
Cell Reports
Summary The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcaed7a63b1e7003b81ae49970f38f63
https://pubmed.ncbi.nlm.nih.gov/27292648
https://pubmed.ncbi.nlm.nih.gov/27292648
Autor:
Christopher Allen, Catherine M Evans, M. O'Brien, Ja Liu Yin, Alan Kenneth Burnett, Rosemary E. Gale, D. C. Linch, Rob S. Sellar, Katarina Lamb, Robert Kerrin Hills, Steven Tinsley
Publikováno v:
Leukemia. 27(9)
Several different mutations collaborate with the fusion proteins in core-binding factor acute myeloid leukemia (CBF-AML) to induce leukemogenesis, but their prognostic significance remains unclear. We screened 354 predominantly younger (60 years) adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e999417323e016a25eda4ed80bb575
https://pubmed.ncbi.nlm.nih.gov/23783394
https://pubmed.ncbi.nlm.nih.gov/23783394
Autor:
Anthony W. Segal, Bradley N. Smith, Phil Ancliff, Abdul Rauf Shakoori, Rosemary E. Gale, Akbar Ali, Georgina W. Hall, Zühre Kaya, David C. Linch, Catherine M Evans, Bu’Hussain Hayee
Causative homozygous or compound heterozygous mutations in the glucose-6-phosphatase, catalytic subunit 3 gene (G6PC3) have recently been described for a sub-group of patients with severe congenital neutropenia (SCN) (Arostegui et al, 2009; Boztug et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e12b3f7224bb1b7f16fff8b9330ebd6
https://avesis.gazi.edu.tr/publication/details/b04cfcc9-49a4-4df1-a61d-6287eb452584/oai
https://avesis.gazi.edu.tr/publication/details/b04cfcc9-49a4-4df1-a61d-6287eb452584/oai
Autor:
Anthony V. Moorman, John Ahman Liu-Yin, David C. Linch, Christopher Allen, Rob S. Sellar, Michelle A. Sale, Alan Kenneth Burnett, Rosemary E. Gale, Catherine M Evans, Katarina Lamb, Robert Kerrin Hills
Publikováno v:
Blood. 118:419-419
Abstract 419 Patients with core binding factor (CBF) AML [t(8;21) and inv(16)/t(16;16)] are generally excluded from transplantation in first CR because of their relatively favorable prognostic outcome with conventional chemotherapy. CBF AML is hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e80a29914ae2689a84b99b610cdb68
https://doi.org/10.1182/blood.v118.21.419.419
https://doi.org/10.1182/blood.v118.21.419.419
Autor:
Rosemary E. Gale, Catherine M Evans, Alan Kenneth Burnett, Lu Zhao, David C. Linch, Claire Green, Robert Kerrin Hills
Publikováno v:
Blood. 116:100-100
Abstract 100 The prognostic implications of specific gene mutations in AML can be dependent on their interaction with other mutations so that large cohorts of patients are required for detailed analyses. For example, we have recently reported that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269695c7e7d3e2b180ca785de9e453d3
https://doi.org/10.1182/blood.v116.21.100.100
https://doi.org/10.1182/blood.v116.21.100.100