Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Catherine M. Davidson"'
Autor:
Neha Agrawal, Katherine Lawler, Catherine M. Davidson, Julia M. Keogh, Robert Legg, INTERVAL, Inês Barroso, I. Sadaf Farooqi, Andrea H. Brand
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establis
Externí odkaz:
https://doaj.org/article/79111040580e450d8f11ece9a93f657d
Autor:
Inês Barroso, I. Sadaf Farooqi, Neha Agrawal, Catherine M. Davidson, Robert Legg, Julia M. Keogh, Katherine Lawler, Andrea H. Brand, Interval
Publikováno v:
Agrawal, N, Lawler, K, Davidson, C M, Keogh, J M, Keogh, J M, Legg, R, Barroso, I, Farooqi, I S & Brand, A H 2021, ' Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila ', PLoS Biology, vol. 19, no. 11, e3001255 . https://doi.org/10.1371/journal.pbio.3001255
PLoS Biology, Vol 19, Iss 11 (2021)
PLoS Biology, Vol 19, Iss 11, p e3001255 (2021)
PLoS Biology, Vol 19, Iss 11 (2021)
PLoS Biology, Vol 19, Iss 11, p e3001255 (2021)
The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated genes. However, establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce9918ad4fa77646fb0de105a46ee79
https://www.pure.ed.ac.uk/ws/files/241297978/journal.pbio.3001255.pdf
https://www.pure.ed.ac.uk/ws/files/241297978/journal.pbio.3001255.pdf
Autor:
Tony D. Southall, Andrea H. Brand, Boris Egger, Owen J. Marshall, Katrina S. Gold, Elizabeth E. Caygill, Catherine M. Davidson
Publikováno v:
Developmental Cell
Summary Cell-type-specific transcriptional profiling often requires the isolation of specific cell types from complex tissues. We have developed “TaDa,” a technique that enables cell-specific profiling without cell isolation. TaDa permits genome-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23deb44ea1db1b8ba9a1ea6722ecdce8
Autor:
Catherine M. Davidson, Terri M. Wells, Jayesh Dudhia, Joseph L E Bird, Michael T. Bayliss, Matthias Mörgelin
Publikováno v:
Biochemical Journal. 370:69-79
The heterogeneity of the components of proteoglycan aggregates, their stoichiometry within the aggregate and the aggregates’ stability was investigated in normal human articular cartilage specimens (age-range newborn to 63 years). Proteoglycans wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e69cd980541858bd028c83576292ad5
https://doi.org/10.1042/bj20020968
https://doi.org/10.1042/bj20020968
Publikováno v:
Journal of Biological Chemistry. 275:6321-6327
The effect of age on the incorporation of newly synthesized aggrecan into the extracellular matrix of human articular cartilage was investigated. This property was measured in a pulse-chase explant culture system by determining the distribution of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54f778e6587b7ac11018e29a9d3749b
https://doi.org/10.1074/jbc.275.9.6321
https://doi.org/10.1074/jbc.275.9.6321
Publikováno v:
Journal of Biological Chemistry. 274:15892-15900
The chondroitin ABC lyase digestion products of normal human femoral condyle articular cartilage and of purified aggrecan were analyzed for their mono- and nonsulfated disaccharide composition. Changes in the total tissue chemistry were most pronounc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d39b95b7b3a46a7a76da8e33668661f6
https://doi.org/10.1074/jbc.274.22.15892
https://doi.org/10.1074/jbc.274.22.15892
Autor:
Acaimo González-Reyes, Fanni Gergely, Andrea H. Brand, Daniel St Johnston, Catherine M. Davidson, Heather Elliott, David Micklem, Ramanuj DasGupta
Publikováno v:
Scopus-Elsevier
Background: Drosophila axis formation requires a series of inductive interactions between the oocyte and the somatic follicle cells. Early in oogenesis, Gurken protein, a member of the transforming growth factor α family, is produced by the oocyte t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4306e9479bc58972bcfaab7dc7265a26
Publikováno v:
Developmental Cell
Summary The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23458b0323fb7cf41ea6d2536217734d
https://pubmed.ncbi.nlm.nih.gov/24631403
https://pubmed.ncbi.nlm.nih.gov/24631403
Publikováno v:
Acta Orthopaedica Scandinavica. 66:22-25
The joint is an organ consisting of diverse connective tissues, each with its own specific extracellular matrix composition, whose metabolism is controlled by an equally diverse range of cell types. Nevertheless, the physiological function of the joi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de23d025769f6691d316935114ebfcaa
https://doi.org/10.3109/17453679509157642
https://doi.org/10.3109/17453679509157642
Publikováno v:
Development (Cambridge, England). 133(16)
Fes/Fer non-receptor tyrosine kinases regulate cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions. Unregulated Fes/Fer kinase activity has been shown to lead to tumours in vivo. Here, we show that Drosophila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89e8f5fd1c7e2e642d9b737aaa7e904
https://pubmed.ncbi.nlm.nih.gov/16831834
https://pubmed.ncbi.nlm.nih.gov/16831834