Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Catherine M. Ambler"'
Autor:
Dafydd R. Owen, James D. Clark, Xiaojing Yang, Eddine Saiah, Martin Hegen, Brian S. Gerstenberger, Felix Vajdos, Catherine M. Ambler, Li Xing, Alpay Dermenci, Tsung H. Lin, Matthew Merrill Hayward, Raman Sharma, Xin Yang, David W. Lin, John D. Knafels, Eric P. Arnold, Mary-Ellen Banker, Stephen W. Wright, Martin E. Dowty, Brett D. Hollingshead, Andrew Fensome, Susan Fish, Matthew Frank Brown
Publikováno v:
Journal of medicinal chemistry. 63(22)
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon family, where it pairs with JAK2 or JAK1, respectively. On the basis of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62513b08e1117b54db6ce345e9512f36
https://pubmed.ncbi.nlm.nih.gov/32787094
https://pubmed.ncbi.nlm.nih.gov/32787094
Autor:
Brett D. Hollingshead, Fabien Vincent, Tsung H. Lin, John I. Trujillo, Betsy Pierce, Andrew Fensome, Brian S. Gerstenberger, Martin E. Dowty, Matthew Frank Brown, Xin Yang, David C. Limburg, Martin Hegen, John D. Knafels, Felix Vajdos, Andrew C. Flick, Mary Ellen Banker, Raman Sharma, Li Xing, Jason Jussif, Catherine M. Ambler, Ivan Viktorovich Efremov, James D. Clark, Liying Zhang, Peter T. Symanowicz, Eddine Saiah, Jill Chrencik, Jean-Baptiste Telliez, Xiaojing Yang, Eric P. Arnold, Ariamala Gopalsamy, Zhao-Kui Wan, Matthew Merrill Hayward, David W. Lin
Publikováno v:
Journal of Medicinal Chemistry. 61:8597-8612
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4f153dbb8b5bb68fb24a9742305143
https://doi.org/10.1021/acs.jmedchem.8b00917
https://doi.org/10.1021/acs.jmedchem.8b00917
Autor:
Romelia Salomon-Ferrer, Lawrence G. Lum, Todd VanArsdale, Nathan V. Lee, Andrew C. Wang, Aihua Zou, Koleen Eisele, Eric C. Greenwald, Catherine M. Ambler, Ana Flores-Bojorquez, Bryan Li, Carl Davis, Sergei Timofeevski, Martha A. Ornelas, Zhenxiong Wang, Penney L. Khamphavong, Samantha Elizabeth Greasley, Indrawan James Mcalpine, Michael F. Maestre, Jian Li, Ben Bolaños, Neil B. Grodsky, Yun Huang, Stephanie Scales, Ted William Johnson, Roksolana Melnychuk, Wade Diehl, Jon Oyer, Jacob DeForest, Sherry Niessen
Publikováno v:
Cancer Research. 81:330-330
Nomination of new oncology targets has been greatly aided by advances in genetic screening and profiling, but developing potent, selective small molecule inhibitors against these targets remains a resource intensive pursuit. To significantly de-risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175a74b477945565e69a9273c2d726b7
https://doi.org/10.1158/1538-7445.am2021-330
https://doi.org/10.1158/1538-7445.am2021-330
Autor:
Michael Ellis Perlman, Orlagh M. Feeney, Glenn A. Edwards, Claire Louise McEvoy, Christopher J.H. Porter, Natalie L. Trevaskis, Catherine M. Ambler
Publikováno v:
Molecular Pharmaceutics. 14:4525-4538
Lipid based formulations (LBFs) are a promising formulation strategy for many poorly water-soluble drugs and have been shown previously to enhance the oral exposure of CP-532,623, an oral cholesteryl ester transfer protein inhibitor. In the current s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9e019175ab939e4eb9d9c9722d7633
https://doi.org/10.1021/acs.molpharmaceut.7b00660
https://doi.org/10.1021/acs.molpharmaceut.7b00660
Autor:
Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
Publikováno v:
Journal of Medicinal Chemistry. 60:5521-5542
Through fragment-based drug design focused on engaging the active site of IRAK4 and leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer fragment library was optimized to afford IRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d71e108dde9e50f577dacbc8e3364e
https://doi.org/10.1021/acs.jmedchem.7b00231
https://doi.org/10.1021/acs.jmedchem.7b00231
Autor:
David C. Limburg, Andrew Fensome, Fabien Vincent, Betsy Pierce, Martin E. Dowty, Mary Ellen Banker, Raman Sharma, Xin Yang, Ariamala Gopalsamy, Roger S. Gifford, Brian S. Gerstenberger, Andrew C. Flick, Eric P. Arnold, Jason Jussif, Ivan Viktorovich Efremov, Xiaojing Yang, Martin Hegen, Zhao-Kui Wan, Felix Vajdos, Catherine M. Ambler, James D. Clark, Tsung H. Lin, John I. Trujillo, Li Xing
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115481
Herein, we disclose a new series of TYK2/ JAK1 inhibitors based upon a 3.1.0 azabicyclic substituted pyrimidine scaffold. We illustrate the use of structure-based drug design for the initial design and subsequent optimization of this series of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4d8bef6390fa6ece1b44635a741fad
https://doi.org/10.1016/j.bmc.2020.115481
https://doi.org/10.1016/j.bmc.2020.115481
Autor:
Andrew, Fensome, Catherine M, Ambler, Eric, Arnold, Mary Ellen, Banker, Matthew F, Brown, Jill, Chrencik, James D, Clark, Martin E, Dowty, Ivan V, Efremov, Andrew, Flick, Brian S, Gerstenberger, Ariamala, Gopalsamy, Matthew M, Hayward, Martin, Hegen, Brett D, Hollingshead, Jason, Jussif, John D, Knafels, David C, Limburg, David, Lin, Tsung H, Lin, Betsy S, Pierce, Eddine, Saiah, Raman, Sharma, Peter T, Symanowicz, Jean-Baptiste, Telliez, John I, Trujillo, Felix F, Vajdos, Fabien, Vincent, Zhao-Kui, Wan, Li, Xing, Xiaojing, Yang, Xin, Yang, Liying, Zhang
Publikováno v:
Journal of medicinal chemistry. 61(19)
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad2ad9462488003d246ff771f1250154
https://pubmed.ncbi.nlm.nih.gov/30113844
https://pubmed.ncbi.nlm.nih.gov/30113844
Publikováno v:
Current Pharmaceutical Design. 21:1327-1336
The targeting of drugs to skeletal muscle is an emerging area of research. Driven by the need for new therapies to treat a range of muscle-associated diseases, these strategies aim to provide improved drug exposure at the site of action in skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04799e74c75d012a1a28832d71954a21
https://doi.org/10.2174/1381612820666140929095755
https://doi.org/10.2174/1381612820666140929095755
Publikováno v:
Translating Molecules into Medicines ISBN: 9783319500409
Thoughtfully designed early clinical formulations not only meet the needs of the study at hand and inform the development of the commercial product, but can influence the direction of the clinical program as well as provide further guidance to potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d66fb7c13b12a23fe10d9c488454bf
https://doi.org/10.1007/978-3-319-50042-3_10
https://doi.org/10.1007/978-3-319-50042-3_10
Autor:
Mohammad Ullah, Ayman El-Kattan, Manthena V.S. Varma, Charles J. Rotter, Katherine S. Fenner, Hao Sun, John Litchfield, Catherine M. Ambler
Publikováno v:
Current Drug Metabolism. 11:730-742
While the oral exposure continues to be the major focus, the chemical space of recent drug discovery is apparently trending towards more hydrophilic libraries, due to toxicity and drug-interactions issues usually reported with lipophilic drugs. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37acd7825bcf384a1dd3e8f618cfb903
https://doi.org/10.2174/138920010794328850
https://doi.org/10.2174/138920010794328850