Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Catherine M Stein"'
Autor:
Michael L McHenry, Jason Simmons, Hyejeong Hong, LaShaunda L Malone, Harriet Mayanja-Kizza, William S Bush, W Henry Boom, Thomas R Hawn, Scott M Williams, Catherine M Stein
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010387 (2023)
BackgroundTuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover genes that explain a large proportion of genetic risk for adult pulmonary TB, and even fewer have exami
Externí odkaz:
https://doaj.org/article/2e0843db2b3d420391bf11e8daa773b9
Autor:
Jason D Simmons, R Max Segnitz, Kimberly A Dill-McFarland, Catherine M Stein, Glenna J Peterson, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284498 (2023)
BackgroundA mechanistic understanding of uncommon immune outcomes such as resistance to infection has led to the development of novel therapies. Using gene level analytic methods, we previously found distinct monocyte transcriptional responses associ
Externí odkaz:
https://doaj.org/article/18e905409be14fb8b0a6884e0c8d5dbf
Autor:
Bonnie A Thiel, William Worodria, Sophie Nalukwago, Mary Nsereko, Ingvar Sanyu, Lalitha Rejani, Josephine Zawedde, David H Canaday, Catherine M Stein, Keith A Chervenak, LaShaunda L Malone, Ronald Kiyemba, Richard F Silver, John L Johnson, Harriet Mayanja-Kizza, W Henry Boom
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249477 (2021)
BackgroundThe search for immune correlates of protection against Mycobacterium tuberculosis (MTB) infection in humans is limited by the focus on peripheral blood measures. Bronchoalveolar lavage (BAL) can safely be done and provides insight into cell
Externí odkaz:
https://doaj.org/article/1dc85d37d8f842fab88fbb40f511fb63
Autor:
Michael L McHenry, Jacquelaine Bartlett, Robert P Igo, Eddie M Wampande, Penelope Benchek, Harriet Mayanja-Kizza, Kyle Fluegge, Noemi B Hall, Sebastien Gagneux, Sarah A Tishkoff, Christian Wejse, Giorgio Sirugo, W Henry Boom, Moses Joloba, Scott M Williams, Catherine M Stein
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008728 (2020)
Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither explains a large portion of disease risk or severity. Based on studies in other infectious d
Externí odkaz:
https://doaj.org/article/1f2b4f7ef2014e068b5e31f09d69b027
Autor:
Eddie M Wampande, Peter Naniima, Ezekiel Mupere, David P Kateete, LaShaunda L Malone, Catherine M Stein, Harriet Mayanja-Kizza, Sebastien Gagneux, W Henry Boom, Moses L Joloba
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221644 (2019)
BackgroundLimited data existed exclusively describing Mycobacterium tuberculosis lineage 3 (MTB-L3), sub-lineages, and clinical manifestations in Kampala, Uganda. This study sought to elucidate the circulating MTB-L3 sub-lineages and their correspond
Externí odkaz:
https://doaj.org/article/b63eec520c404996bfb2cd37bf48413d
Autor:
E. Ricky Chan, Penelope Benchek, Gabrielle Miller, Kim Brustoski, Ashleigh Schaffer, Barbara Truitt, Jessica Tag, Lisa Freebairn, Barbara A. Lewis, Catherine M. Stein, Sudha K. Iyengar
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Childhood apraxia of speech (CAS) is a severe and rare form of speech sound disorder (SSD). CAS is typically sporadic, but may segregate in families with broader speech and language deficits. We hypothesize that genetic changes may be involv
Externí odkaz:
https://doaj.org/article/400fb69bb6e74c66b15212f4f8ec8dbd
Autor:
Audrey C Papp, Abul K Azad, Maciej Pietrzak, Amanda Williams, Samuel K Handelman, Robert P Igo, Catherine M Stein, Katherine Hartmann, Larry S Schlesinger, Wolfgang Sadee
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198221 (2018)
Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood monocyte-derived macrophages (MDM) are a model for investigating M.tb-macrophage interactions.
Externí odkaz:
https://doaj.org/article/e28290c5f68e46aa883fa2d95c42d8e0
Autor:
Rafal S Sobota, Catherine M Stein, Nuri Kodaman, Isaac Maro, Wendy Wieland-Alter, Robert P Igo, Albert Magohe, LaShaunda L Malone, Keith Chervenak, Noemi B Hall, Mecky Matee, Harriet Mayanja-Kizza, Moses Joloba, Jason H Moore, William K Scott, Timothy Lahey, W Henry Boom, C Fordham von Reyn, Scott M Williams, Giorgio Sirugo
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006710 (2017)
One in three people has been infected with Mycobacterium tuberculosis (MTB), and the risk for MTB infection in HIV-infected individuals is even higher. We hypothesized that HIV-positive individuals living in tuberculosis-endemic regions who do not ge
Externí odkaz:
https://doaj.org/article/39b8f996319a481d8ac25d7c8934bd1c
Autor:
Chetan Seshadri, Nafiseh Sedaghat, Monica Campo, Glenna Peterson, Richard D Wells, Gregory S Olson, David R Sherman, Catherine M Stein, Harriet Mayanja-Kizza, Ali Shojaie, W Henry Boom, Thomas R Hawn, Tuberculosis Research Unit (TBRU)
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175844 (2017)
RationaleUnderstanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV.ObjectivesTo compare the early transcriptional response of
Externí odkaz:
https://doaj.org/article/be1f5fc0e02c4c509ccb60eacd7db1ef
Autor:
Kimberly A. Dill-McFarland, Jason D. Simmons, Glenna J. Peterson, Felicia K. Nguyen, Monica Campo, Penelope Benchek, Catherine M. Stein, Tomas Vaisar, Harriet Mayanja-Kizza, W. Henry Boom, Thomas R. Hawn
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT Mycobacterium tuberculosis (Mtb) exposure leads to a range of outcomes including clearance, latent TB infection (LTBI), and pulmonary tuberculosis (TB). Some heavily exposed individuals resist tuberculin skin test (TST) and interferon-gamma
Externí odkaz:
https://doaj.org/article/b5310dd7b1304cafaf2e9ec3f37e81f3