Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Catherine M Keenan"'
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144270 (2015)
Acute administration of cannabinoid CB1 receptor agonists, or the ingestion of cannabis, induces short-term hyperphagia. However, the incidence of obesity is lower in frequent cannabis users compared to non-users. Gut microbiota affects host metaboli
Externí odkaz:
https://doaj.org/article/f72042317a744917959e441a0c1d4132
Autor:
Fernando A. Vicentini, Catherine M. Keenan, Laurie E. Wallace, Crystal Woods, Jean-Baptiste Cavin, Amanda R. Flockton, Wendy B. Macklin, Jaime Belkind-Gerson, Simon A. Hirota, Keith A. Sharkey
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-24 (2021)
Abstract Background The intestinal microbiota plays an important role in regulating gastrointestinal (GI) physiology in part through interactions with the enteric nervous system (ENS). Alterations in the gut microbiome frequently occur together with
Externí odkaz:
https://doaj.org/article/c218aabe31c34611bbed7773547b1901
Autor:
Erik van Tilburg Bernardes, Veronika Kuchařová Pettersen, Mackenzie W. Gutierrez, Isabelle Laforest-Lapointe, Nicholas G. Jendzjowsky, Jean-Baptiste Cavin, Fernando A. Vicentini, Catherine M. Keenan, Hena R. Ramay, Jumana Samara, Wallace K. MacNaughton, Richard J. A. Wilson, Margaret M. Kelly, Kathy D. McCoy, Keith A. Sharkey, Marie-Claire Arrieta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The immunomodulatory role of commensal gut fungi and interactions with bacteria remain unclear. Here, using germ-free mice colonized with defined species of bacteria and fungi, the authors find that fungal colonization induces changes in bacterial mi
Externí odkaz:
https://doaj.org/article/7e7a71db7d15468095e5d2a5ace43434
Autor:
Haley A. Vecchiarelli, Robert J. Aukema, Catherine Hume, Vincent Chiang, Maria Morena, Catherine M. Keenan, Andrei S. Nastase, Francis S. Lee, Quentin J. Pittman, Keith A. Sharkey, Matthew N. Hill
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Cannabinoids, including cannabis derived phytocannabinoids and endogenous cannabinoids (endocannabinoids), are typically considered anti-inflammatory. One such endocannabinoid is N-arachidonoylethanolamine (anandamide, AEA), which is metabolized by f
Externí odkaz:
https://doaj.org/article/5bee354e39844c43a6f96c4715ec912f
Autor:
Crystal Woods, Amanda R. Flockton, Laurie E. Wallace, Catherine M. Keenan, Wendy B. Macklin, Keith A. Sharkey, Jaime Belkind-Gerson
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G115-G130
Proteolipid protein 1 (Plp1) is highly expressed in enteric glia, labeling cells throughout the mucosa, muscularis and the extrinsic innervation. Plp1 is a major constituent of myelin in the central and peripheral nervous systems, but the absence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa533b64a7f63a5c0438e39ef5feb812
https://doi.org/10.1152/ajpgi.00171.2022
https://doi.org/10.1152/ajpgi.00171.2022
Autor:
Hailey, Cuddihey, Jean-Baptiste, Cavin, Catherine M, Keenan, Laurie E, Wallace, Kiran, Vemuri, Alexandros, Makriyannis, Wallace K, MacNaughton, Keith A, Sharkey
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 323(3)
The endocannabinoid system of the gastrointestinal tract is involved in the control of intestinal barrier function. Whether the cannabinoid 1 (CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a56d5219a7fdd57816c619e64c1026a
https://pubmed.ncbi.nlm.nih.gov/35787179
https://pubmed.ncbi.nlm.nih.gov/35787179
Autor:
Hailey Cuddihey, Jean-Baptiste Cavin, Catherine M. Keenan, Laurie E. Wallace, Kiran Vemuri, Alexandros Makriyannis, Wallace K. MacNaughton, Keith A. Sharkey
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G219-G238
The endocannabinoid system of the gastrointestinal tract regulates homeostasis by acting as brake on motility and secretion. Here we show that when exposed to a high fat diet, intestinal permeability is increased and activation of the CB1 receptor on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a9de68d536de576dde8d8969c2fb00
https://doi.org/10.1152/ajpgi.00341.2021
https://doi.org/10.1152/ajpgi.00341.2021
Autor:
Rachel M. Kratofil, Hanjoo B. Shim, Raymond Shim, Woo Yong Lee, Elodie Labit, Sarthak Sinha, Catherine M. Keenan, Bas G. J. Surewaard, Ji Yeon Noh, Yuxiang Sun, Keith A. Sharkey, Matthias Mack, Jeff Biernaskie, Justin F. Deniset, Paul Kubes
Publikováno v:
Nature. 609:166-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bc066dc957cd763de31eef8439f9c4
https://doi.org/10.1038/s41586-022-05044-x
https://doi.org/10.1038/s41586-022-05044-x
Autor:
Yiran Wu, Keith A. Sharkey, Zhi-Jie Liu, Tian Hua, Alexandros Makriyannis, Catherine M. Keenan, Nikolai Zvonok, Ganesh A. Thakur, Christina A Brust, Travis W. Grim, Simiao Wu, Spyros P. Nikas, Shan Jiang, Fei Tong, Jimit Girish Raghav, Christos Iliopoulos-Tsoutsouvas, Laura M. Bohn, Jo-Hao Ho
Publikováno v:
Journal of Medicinal Chemistry. 64:3870-3884
We report the development of novel cannabinergic probes that can stabilize the cannabinoid receptors (CBRs) through tight binding interactions. Ligand design involves the introduction of select groups at a judiciously chosen position within the class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacc995a95fe6313b35de02e29e172dc
https://doi.org/10.1021/acs.jmedchem.0c02053
https://doi.org/10.1021/acs.jmedchem.0c02053
Autor:
Catherine M. Keenan, Matthew N. Hill, Vincent Chiang, Haley A. Vecchiarelli, Quentin J. Pittman, Kira D. Leitl, Kaitlyn Tan, Alessia Santori, Min Qiao, Keith A. Sharkey, Maria Morena
Publikováno v:
Neuropsychopharmacology
Peripheral inflammatory conditions, including those localized to the gastrointestinal tract, are highly comorbid with psychiatric disorders such as anxiety and depression. These behavioral symptoms are poorly managed by conventional treatments for in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a24bd0dd3844063c2f0e3889fb3ecb7
https://doi.org/10.1038/s41386-020-00939-7
https://doi.org/10.1038/s41386-020-00939-7