Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Catherine M K Ho"'
Autor:
Catherine M K Ho, I'ah Z Donovan-Banfield, Li Tan, Tinghu Zhang, Nathanael S Gray, Blair L Strang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150339 (2016)
Protein kinase inhibitors can be used as tools to identify proteins and pathways required for virus replication. Using virus replication assays and western blotting we found that the widely used protein kinase inhibitor BAY61-3606 inhibits replicatio
Externí odkaz:
https://doaj.org/article/2e09638a929b49d7bf883c48b409b917
Autor:
Teresa Lambe, Alexandra J. Spencer, Kelly M. Thomas, Karen E. Gooch, Stephen Thomas, Andrew D. White, Holly E. Humphries, Daniel Wright, Sandra Belij-Rammerstorfer, Nazia Thakur, Carina Conceicao, Robert Watson, Leonie Alden, Lauren Allen, Marilyn Aram, Kevin R. Bewley, Emily Brunt, Phillip Brown, Breeze E. Cavell, Rebecca Cobb, Susan A. Fotheringham, Ciaran Gilbride, Debbie J. Harris, Catherine M. K. Ho, Laura Hunter, Chelsea L. Kennard, Stephanie Leung, Vanessa Lucas, Didier Ngabo, Kathryn A. Ryan, Hannah Sharpe, Charlotte Sarfas, Laura Sibley, Gillian S. Slack, Marta Ulaszewska, Nadina Wand, Nathan R. Wiblin, Fergus V. Gleeson, Dalan Bailey, Sally Sharpe, Sue Charlton, Francisco J. Salguero, Miles W. Carroll, Sarah C. Gilbert
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induce
Externí odkaz:
https://doaj.org/article/9f8c33e0c50a4a85acb2b5617681d0f4
Autor:
Francisco J. Salguero, Andrew D. White, Gillian S. Slack, Susan A. Fotheringham, Kevin R. Bewley, Karen E. Gooch, Stephanie Longet, Holly E. Humphries, Robert J. Watson, Laura Hunter, Kathryn A. Ryan, Yper Hall, Laura Sibley, Charlotte Sarfas, Lauren Allen, Marilyn Aram, Emily Brunt, Phillip Brown, Karen R. Buttigieg, Breeze E. Cavell, Rebecca Cobb, Naomi S. Coombes, Alistair Darby, Owen Daykin-Pont, Michael J. Elmore, Isabel Garcia-Dorival, Konstantinos Gkolfinos, Kerry J. Godwin, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas Hender, Catherine M. K. Ho, Chelsea L. Kennard, Daniel Knott, Stephanie Leung, Vanessa Lucas, Adam Mabbutt, Alexandra L. Morrison, Charlotte Nelson, Didier Ngabo, Jemma Paterson, Elizabeth J. Penn, Steve Pullan, Irene Taylor, Tom Tipton, Stephen Thomas, Julia A. Tree, Carrie Turner, Edith Vamos, Nadina Wand, Nathan R. Wiblin, Sue Charlton, Xiaofeng Dong, Bassam Hallis, Geoffrey Pearson, Emma L. Rayner, Andrew G. Nicholson, Simon G. Funnell, Julian A. Hiscox, Mike J. Dennis, Fergus V. Gleeson, Sally Sharpe, Miles W. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung h
Externí odkaz:
https://doaj.org/article/87631802f4e34ba091e1f0a793783536
Autor:
Kathryn A. Ryan, Kevin R. Bewley, Susan A. Fotheringham, Gillian S. Slack, Phillip Brown, Yper Hall, Nadina I. Wand, Anthony C. Marriott, Breeze E. Cavell, Julia A. Tree, Lauren Allen, Marilyn J. Aram, Thomas J. Bean, Emily Brunt, Karen R. Buttigieg, Daniel P. Carter, Rebecca Cobb, Naomi S. Coombes, Steve J. Findlay-Wilson, Kerry J. Godwin, Karen E. Gooch, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas H. Hender, Holly E. Humphries, Laura Hunter, Catherine M. K. Ho, Chelsea L. Kennard, Stephanie Leung, Stephanie Longet, Didier Ngabo, Karen L. Osman, Jemma Paterson, Elizabeth J. Penn, Steven T. Pullan, Emma Rayner, Oliver Skinner, Kimberley Steeds, Irene Taylor, Tom Tipton, Stephen Thomas, Carrie Turner, Robert J. Watson, Nathan R. Wiblin, Sue Charlton, Bassam Hallis, Julian A. Hiscox, Simon Funnell, Mike J. Dennis, Catherine J. Whittaker, Michael G. Catton, Julian Druce, Francisco J. Salguero, Miles W. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidenc
Externí odkaz:
https://doaj.org/article/a8afc90cbc2f4422be7dc5bc8923c3cf
Autor:
Blair L Strang, Christopher R M Asquith, Hanan F Moshrif, Catherine M-K Ho, William J Zuercher, Hassan Al-Ali
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201321 (2018)
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug targets. We have previously screened a collection of highly characterized kinase inhibitors (Khan
Externí odkaz:
https://doaj.org/article/dad782f96f9748ddba6e6688220794e8
Autor:
Nadina Wand, Irene Taylor, Didier Ngabo, Vanessa Lucas, Rebecca Cobb, Rachel Halkerston, Susan A. Fotheringham, Stephanie Leung, Alexandra L. Morrison, Tom Tipton, Holly E. Humphries, Bassam Hallis, Phillip Brown, Kerry J Godwin, Stephen Thomas, Isabel García-Dorival, Emily Brunt, Robert J. Watson, Thomas Hender, Charlotte Nelson, Laura Hunter, Andrew White, Gillian S. Slack, Michael J. Elmore, Owen Daykin-Pont, Nathan R Wiblin, Miles W. Carroll, Breeze E. Cavell, Charlotte Sarfas, Simon G. P. Funnell, Francisco J. Salguero, Karen R. Buttigieg, Carrie Turner, Kevin R. Bewley, Jade Gouriet, Yper Hall, Marilyn Aram, Kathryn A. Ryan, Adam Mabbutt, Steve Pullan, Konstantinos Gkolfinos, Julia A. Tree, Geoffrey Pearson, Lauren Allen, Debbie J Harris, Andrew G. Nicholson, Sue Charlton, Alistair C. Darby, Naomi Coombes, Edith Vamos, Daniel Knott, Karen E. Gooch, Catherine M K Ho, Stephanie Longet, Chelsea L Kennard, Julian A. Hiscox, Xiaofeng Dong, Jemma Paterson, Mike Dennis, Emma Rayner, Fergus V. Gleeson, Elizabeth J Penn, Sally Sharpe, Laura Sibley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81382fb4483dd9827de4444c0a83e573
https://doaj.org/article/87631802f4e34ba091e1f0a793783536
https://doaj.org/article/87631802f4e34ba091e1f0a793783536
Autor:
Nicole Falci Finardi, HyeongJun Kim, Lee Z. Hernandez, Matthew R. G. Russell, Catherine M-K Ho, Vattipally B. Sreenu, Hannah A. Wenham, Andy Merritt, Blair L. Strang
Publikováno v:
The Journal of General Virology
The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026b318e923bdbedde7b587309efdee2
https://openaccess.sgul.ac.uk/id/eprint/113794/23/jgv001702.pdf
https://openaccess.sgul.ac.uk/id/eprint/113794/23/jgv001702.pdf
Autor:
Geoff Pearson, Marilyn Aram, Kin Chan, Rebecca A. Russell, Emma Rayner, Lauren Allen, Phillip Brown, Emily Brunt, Simon G. P. Funnell, Sally Sharpe, Debbie J Harris, Teresa Lambe, Charlotte Sarfas, Leonie Alden, Laura Sibley, Francisco J. Salguero, Andrew Gorringe, Kevin R. Bewley, Miles W. Carroll, Sue Charlton, Kathryn A. Ryan, Stephanie Longet, Chelsea L Kennard, Karen E. Gooch, Catherine M K Ho, Rebecca Cobb, Fergus V. Gleeson, Xiaochao Xue, Nathan R Wiblin, Nadina Wand, Susan A. Fotheringham, Quentin J. Sattentau, Kelly M. Thomas, Laura Hunter, Sarah C. Gilbert, Howard Tolley, Holly E. Humphries, Andrew White, Natalie Baker, Gillian S. Slack, Yper Hall, Stephanie Leung
Publikováno v:
Science Advances. 7
There is an urgent requirement for safe and effective vaccines to prevent COVID-19. A concern for the development of new viral vaccines is the potential to induce vaccine-enhanced disease (VED). This was reported in several preclinical studies with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd9ab14a40593fc7510e375d4422db
https://doi.org/10.1126/sciadv.abg7996
https://doi.org/10.1126/sciadv.abg7996
Autor:
Nathan R Wiblin, Fergus V. Gleeson, Lauren Allen, Daniel B. Wright, Debbie J Harris, Leonie Alden, Teresa Lambe, Alexandra J. Spencer, Sarah C. Gilbert, Stephanie Leung, Miles W. Carroll, Kevin R. Bewley, Nadina Wand, Andrew White, Hannah Sharpe, Susan A. Fotheringham, Kathryn A. Ryan, Marta Ulaszewska, Gillian S. Slack, Carina Conceicao, Didier Ngabo, Stephen Thomas, Phillip Brown, Laura Hunter, Sue Charlton, Holly E. Humphries, Vanessa Lucas, Karen E. Gooch, Nazia Thakur, Ciaran Gilbride, Robert J. Watson, Catherine M K Ho, Emily Brunt, Rebecca Cobb, Sandra Belij-Rammerstorfer, Marilyn Aram, Breeze E. Cavell, Kelly M. Thomas, Dalan Bailey, Sally Sharpe, Laura Sibley, Charlotte Sarfas, Francisco J. Salguero, Chelsea L Kennard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology
Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d85c7556dab6aa65b5dd213486881c
https://doi.org/10.1038/s42003-021-02443-0
https://doi.org/10.1038/s42003-021-02443-0
Autor:
Breeze E. Cavell, Marilyn Aram, Nadina Wand, Stuart D. Dowall, Susan A. Fotheringham, Daphne Tsitoura, Brendon Y. Chua, Stephen Thomas, Ian Holmes, David C. Jackson, Robert J. Watson, Pamela C. Proud, Didier Ngabo, Francesca A. Mercuri, Kevin R. Bewley, Vanessa Lucas, Kathryn A. Ryan, Gillian S. Slack, Weiguang Zeng, Christophe Demaison, Miles W. Carroll, Rebecca Cobb, Emma Rayner, Catherine M K Ho, Paul Yeates, Nathan W. Bartlett
Publikováno v:
EBioMedicine
EBioMedicine, Vol 63, Iss, Pp 103153-(2021)
EBioMedicine, Vol 63, Iss, Pp 103153-(2021)
BACKGROUND: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the upper respiratory tract (URT). Infected individuals are often asymptoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21cacb67acae468a1e1f7b7e9cd3eae