Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Catherine M Hawrylowicz"'
Autor:
Guo-Qiang Zhang, Jin-Liang Chen, Ying Luo, Maya B Mathur, Panagiotis Anagnostis, Ulugbek Nurmatov, Madar Talibov, Jing Zhang, Catherine M Hawrylowicz, Mary Ann Lumsden, Hilary Critchley, Aziz Sheikh, Bo Lundbäck, Cecilia Lässer, Hannu Kankaanranta, Siew Hwa Lee, Bright I Nwaru
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003731 (2021)
BackgroundThere remains uncertainty about the impact of menopausal hormone therapy (MHT) on women's health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking. We conducted an umbrella review to comprehensively summ
Externí odkaz:
https://doaj.org/article/1358ed9466bc42959110f8af4b93e9cb
Autor:
Paul E Pfeffer, Haw Lu, Elizabeth H Mann, Yin-Huai Chen, Tzer-Ren Ho, David J Cousins, Chris Corrigan, Frank J Kelly, Ian S Mudway, Catherine M Hawrylowicz
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200040 (2018)
BACKGROUND:Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma. OBJECTIVES:Mechanistic cell culture experiments were
Externí odkaz:
https://doaj.org/article/f3d696009af0456f861023d1f64c4a4a
Autor:
Chidchamai Kewcharoenwong, Aranya Khongmee, Arnone Nithichanon, Tanapat Palaga, Tassanee Prueksasit, Ian S. Mudway, Catherine M. Hawrylowicz, Ganjana Lertmemongkolchai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Recent evidence has demonstrated that both acute and chronic exposure to particulate air pollution are risk factors for respiratory tract infections and increased mortality from sepsis. There is therefore an urgent need to establish the impa
Externí odkaz:
https://doaj.org/article/7cbc641c90034929b4659fff8cd7b004
Autor:
Yin-Huai Chen, Charlotte E. Cheadle, Louise V. Rice, Paul E. Pfeffer, Sarah Dimeloe, Atul Gupta, Andrew Bush, Bibek Gooptu, Catherine M. Hawrylowicz
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Background: Vitamin D upregulates anti-inflammatory and antimicrobial pathways that promote respiratory health. Vitamin D synthesis is initiated following skin exposure to sunlight, however nutritional supplementation can be required to address defic
Externí odkaz:
https://doaj.org/article/b0c6919f7bbe468cadcca2b6e80f55df
Autor:
Colin R Simpson, Hilary O. D. Critchley, Syed Ahmar Shah, Francis Appiagyei, Catherine M. Hawrylowicz, Ireneous N. Soyiri, Dermot Ryan, David Price, Holly Tibble, Aziz Sheikh, Bright I Nwaru, Rebecca Pillinger, Susannah McLean
Publikováno v:
Nwaru, B I, Tibble, H, Shah, S A, Pillinger, R, Mclean, S, Ryan, D P, Critchley, H, Price, D B, Hawrylowicz, C M, Simpson, C R, Soyiri, I N, Appiagyei, F & Sheikh, A 2020, ' Hormonal contraception and the risk of severe asthma exacerbation : 17-year population-based cohort study ', Thorax, pp. thoraxjnl-2020-215540 . https://doi.org/10.1136/thoraxjnl-2020-215540
BackgroundLongitudinal studies investigating impact of exogenous sex steroids on clinical outcomes of asthma in women are lacking. We investigated the association between use of hormonal contraceptives and risk of severe asthma exacerbation in reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86b48714a64a546186d69401671740a
https://doi.org/10.1136/thoraxjnl-2020-215540
https://doi.org/10.1136/thoraxjnl-2020-215540
Hormonal contraceptives and onset of asthma in reproductive-age women: Population-based cohort study
Autor:
Rebecca Pillinger, Ireneous N. Soyiri, Syed Ahmar Shah, Holly Tibble, Catherine M. Hawrylowicz, Dermot Ryan, Colin R Simpson, Bright I Nwaru, Francis Appiagyei, Hilary O. D. Critchley, Aziz Sheikh, David Price
Publikováno v:
Nwaru, B, Pillinger, R, Tibble, H, Shah, S A, Ryan, D, Critchley, H, Price, D, Hawrylowicz, C M, Simpson, C, Soyiri, I, Appiagyei, F & Sheikh, A 2020, ' Hormonal contraceptives and onset of asthma in reproductive-age women: population-based cohort study ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2020.02.027
Background: Despite well-described sex differences in asthma incidence, there remains uncertainty about the role of female sex hormones in the development of asthma. Objective: To investigate whether hormonal contraceptive use, its subtypes, and dura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3961b464c51e827b3e5078ebd157c78
https://doi.org/10.1016/j.jaci.2020.02.027
https://doi.org/10.1016/j.jaci.2020.02.027
Publikováno v:
Free Radical Biology and Medicine. 151:56-68
A well-functioning immune system is vital for a healthy body. Inadequate and excessive immune responses underlie diverse pathologies such as serious infections, metastatic malignancies and auto-immune conditions. Therefore, understanding the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011578274521477269d417ef083f402d
https://doi.org/10.1016/j.freeradbiomed.2020.01.179
https://doi.org/10.1016/j.freeradbiomed.2020.01.179
Publikováno v:
Current Opinion in Allergy & Clinical Immunology. 20:181-187
PURPOSE OF REVIEW To review recent evidence on the capacity of vitamin D to prevent atopic disease, focussing on food allergy and asthma, and potential underlying mechanisms. RECENT FINDINGS The incidence of allergic disease continues to increase wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a1cd64244d2bbe57c948373d1a412d
https://doi.org/10.1097/aci.0000000000000613
https://doi.org/10.1097/aci.0000000000000613
Autor:
Maya B. Mathur, Jing Zhang, Hilary O. D. Critchley, Panagiotis Anagnostis, Siew Hwa Lee, Guo-Qiang Zhang, Jin Liang Chen, Ying Luo, Mary Ann Lumsden, Cecilia Lässer, Hannu Kankaanranta, Aziz Sheikh, Ulugbek Nurmatov, Bo Lundbäck, Catherine M. Hawrylowicz, Madar Talibov, Bright I Nwaru
Publikováno v:
PLoS Medicine, Vol 18, Iss 8, p e1003731 (2021)
Zhang, G-Q, Chen, J-L, Luo, Y, Mathur, M B, Anagnostis, P, Nurmatov, U, Talibov, M, Zhang, J, Hawrylowicz, C M, Lumsden, M A, Critchley, H, Sheikh, A, Lundbäck, B, Lässer, C, Kankaanranta, H, Lee, S H & Nwaru, B I 2021, ' Menopausal hormone therapy and women's health : An umbrella review ', PLoS Medicine, vol. 18, no. 8, pp. e1003731 . https://doi.org/10.1371/journal.pmed.1003731
PLoS Medicine
Zhang, G-Q, Chen, J-L, Luo, Y, Mathur, M B, Anagnostis, P, Nurmatov, U, Talibov, M, Zhang, J, Hawrylowicz, C M, Lumsden, M A, Critchley, H, Sheikh, A, Lundbäck, B, Lässer, C, Kankaanranta, H, Lee, S H & Nwaru, B I 2021, ' Menopausal hormone therapy and women's health : An umbrella review ', PLoS Medicine, vol. 18, no. 8, pp. e1003731 . https://doi.org/10.1371/journal.pmed.1003731
PLoS Medicine
Background There remains uncertainty about the impact of menopausal hormone therapy (MHT) on women’s health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking. We conducted an umbrella review to comprehensively s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee32ee3768c1e0b978356a030add6c3
https://orca.cardiff.ac.uk/id/eprint/144544/3/journal.pmed.1003731.pdf
https://orca.cardiff.ac.uk/id/eprint/144544/3/journal.pmed.1003731.pdf
Publikováno v:
Mann, E H, Gabryšová, L, Pfeffer, P E, O’Garra, A & Hawrylowicz, C M 2019, ' High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17 + IL-10 + Memory CD4 + T Cell Response towards a Single IL-10–Producing Phenotype ', The Journal of Immunology, vol. 202, no. 3, ji1800697, pp. 684-693 . https://doi.org/10.4049/jimmunol.1800697
Glucocorticoids are known to increase production of the anti-inflammatory cytokine IL-10, and this action is associated with their clinical efficacy in asthmatics. However, glucocorticoids also enhance the synthesis of IL-17A by PBMCs, which, in exce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304c0ae189fd87d693d31f96c1b39eae
https://doi.org/10.4049/jimmunol.1800697
https://doi.org/10.4049/jimmunol.1800697