Výsledky vyhledávání - "Catherine Lequeu"

Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation

Autor: Lionel Piroth, Pascal Chavanet, Manuel Etienne, Jérôme Pugin, Delphine Croisier, Henri Portier, Pierre Emmanuel Charles, Laurent Martin, Catherine Lequeu

Publikováno v: Intensive Care Medicine

Objective Ventilatory strategies combining low tidal volume (VT) with positive end-expiratory pressure (PEEP) are considered to be lung protective. The influence of the PEEP level was investigated on bacteriology and histology in a model of ventilato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8918ee3fec954e2f382d66b4acea41a9
http://europepmc.org/articles/PMC7095170

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Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy

Autor: Manuel Etienne, Emilie Bergoin, Pierre-Emmanuel Charles, Delphine Croisier, Lionel Piroth, Pascal Chavanet, Catherine Lequeu, Henri Portier

Publikováno v: Antimicrobial Agents and Chemotherapy. 48:1699-1707

For some pneumococci the fluoroquinolone MICs are low but the mutant prevention concentrations (MPCs) are high; this difference defines in vitro the mutant selection window (MSW). We investigated in vivo the bacterial reduction and the occurrence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03539e0cb18b7f04a5af074dc3313b23
https://doi.org/10.1128/aac.48.5.1699-1707.2004

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Fractional Maximal Effect Method for In Vitro Synergy between Amoxicillin and Ceftriaxone and between Vancomycin and Ceftriaxone against Enterococcus faecalis and Penicillin-Resistant Streptococcus pneumoniae

Autor: Lionel Piroth, Pascal Chavanet, Catherine Neuwirth, Henri Portier, Norbert Desbiolles, Catherine Lequeu

Publikováno v: Antimicrobial Agents and Chemotherapy. 45:3328-3333

In the present study we assessed the use of a new in vitro testing method and graphical representation of the results to investigate the potential effectiveness of combinations of amoxicillin (AMZ) plus ceftriaxone (CRO) and of CRO plus vancomycin (V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d475324651db00b5e5876b2bc8b09f0
https://doi.org/10.1128/aac.45.12.3328-3333.2001

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HMR 3647 human-like treatment of experimental pneumonia due to penicillin-resistant and erythromycin-resistant Streptococcus pneumoniae

Autor: Pascal Chavanet, Norbert Desbiolles, Vanessa Mateo-Ponce, Lionel Piroth, Catherine Lequeu, Pierre-Emmanuel Charles, Henri Portier, Laurent Martin

Publikováno v: Journal of Antimicrobial Chemotherapy. 47:33-42

An experimental Streptococcus pneumoniae pneumonia model in rabbits was used to assess the efficacy of amoxycillin, erythromycin and a new ketolide, telithromycin (HMR 3647). The MICs of amoxycillin, erythromycin and HMR 3647 for the three clinical S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d7e21885393798db3d407935144372
https://doi.org/10.1093/jac/47.1.33

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Efficacy of humanlike Augmentin SR (2000/125 mg) twice daily treatment on Haemophilus influenzae experimental pneumonia in rabbits

Autor: Pascal Chavanet, David Durand, Lionel Piroth, Henri Portier, Delphine Croisier, Catherine Lequeu, Martha Benoit

Publikováno v: Scandinavian journal of infectious diseases. 39(2)

We investigated the efficacy of 2 formulations of Augmentin on experimental pneumonia due to Haemophilus influenzae (HI) in rabbits. Two strains were used (H128 and 401285) with amoxicillin/clavulanic acid MICs of 1/0.5 mg/l and 4/2 mg/l. Pneumonia w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39a562e3ff3fe5d14ce46cbd0344fe2
https://pubmed.ncbi.nlm.nih.gov/17366027

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The impact of mechanical ventilation on the moxifloxacin treatment of experimental pneumonia caused by Streptococcus pneumoniae

Autor: Lionel Piroth, Pierre Emmanuel Charles, Jérôme Pugin, Henri Portier, Delphine Croisier, Manuel Etienne, Pascal Chavanet, Catherine Lequeu

Publikováno v: Critical care medicine. 33(5)

Objective: Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and is responsible for early-onset ventilator-associated pneumonia as well. In intensive care units, community-acquired pneumonia is still associated with a mortal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b34cab39dc2b63e853f92cbe8d9bf7a
https://pubmed.ncbi.nlm.nih.gov/15891332

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In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants

Autor: Catherine Lequeu, Delphine Croisier, Henri Portier, Manuel Etienne, Pascal Chavanet, Lionel Piroth, Emilie Bergoin

Publikováno v: The Journal of antimicrobial chemotherapy. 54(3)

To investigate the impact of low levels of fluoroquinolone resistance on the emergence of resistant mutants, we examined the mutant selection window (MSW) hypothesis in experimental pneumonia in rabbits infected with pneumococci with various suscepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae564d194356d22cab411d47ecaead43
https://pubmed.ncbi.nlm.nih.gov/15317743

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Effect of low-level resistance on subsequent enrichment of fluoroquinolone-resistant Streptococcus pneumoniae in rabbits

Autor: Lionel Piroth, Manuel Etienne, Pierre-Emmanuel Charles, Henri Portier, Karl Drlica, Delphine Croisier, Pascal Chavanet, Catherine Lequeu

Publikováno v: The Journal of infectious diseases. 190(8)

Background. We measured the effect of low-level fluoroquinolone resistance in Streptococcus pneumoniae on the development of high-level resistance within the context of the mutant selection window. Methods. Rabbits infected with S. pneumoniae were tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ce8e82d351309ac65166a44705a142
https://pubmed.ncbi.nlm.nih.gov/15378440

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New model of ventilator-associated pneumonia in immunocompetent rabbits

Autor: Catherine Lequeu, Lionel Piroth, Pierre-Emmanuel Charles, Pascal Chavanet, Norbert Desbiolles, Henri Portier, Laurent Martin

Publikováno v: Critical care medicine. 30(10)

Despite the high rate of therapeutic failures in ventilator-associated pneumonia, up to now there has been no animal model specifically designed for antimicrobial evaluation. A rabbit model of ventilator-associated pneumonia is described for the firs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df425eecf2cf24c749ecbd17eaf2ce4
https://pubmed.ncbi.nlm.nih.gov/12394981

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Efficacy and pharmacodynamics of simulated human-like treatment with levofloxacin on experimental pneumonia induced with penicillin-resistant pneumococci with various susceptibilities to fluoroquinolones

Autor: Delphine, Croisier, Pascal, Chavanet, Catherine, Lequeu, Abderrahmane, Ahanou, Anne, Nierlich, Catherine, Neuwirth, Lionel, Piroth, Michel, Duong, Marielle, Buisson, Henri, Portier

Publikováno v: The Journal of antimicrobial chemotherapy. 50(3)

Newer fluoroquinolones, such as levofloxacin, have shown an enhanced in vitro and in vivo activity against penicillin-resistant Streptococcus pneumoniae infections. The frequency of S. pneumoniae with reduced susceptibility to quinolones, although cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea31225151e0c81c329270bf5b6bf3e
https://pubmed.ncbi.nlm.nih.gov/12697636

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