Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Catherine Lee May"'
Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1
Autor:
Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in
Externí odkaz:
https://doaj.org/article/1ec8f8f1cc1c4bba80901ee1adb464df
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101193- (2021)
Objective: While the molecular events controlling insulin secretion from β-cells have been documented in detail, the exact mechanisms governing glucagon release by α-cells are understood only partially. This is a critical knowledge gap, as the norm
Externí odkaz:
https://doaj.org/article/837754ad260f4f72819b813c7936915a
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66214 (2013)
The specification and differentiation of pancreatic endocrine cell populations (α-, β-, δ, PP- and ε-cells) is orchestrated by a combination of transcriptional regulators. In the pancreas, Aristaless-related homeobox gene (Arx) is expressed first
Externí odkaz:
https://doaj.org/article/b53c886b2b1d423eb27247516fd439be
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78741 (2013)
ARX/Arx is a homeodomain-containing transcription factor necessary for the specification and early maintenance of pancreatic endocrine α-cells. Many transcription factors important to pancreas development, including ARX/Arx, are also crucial for pro
Externí odkaz:
https://doaj.org/article/0d9d4a47b68d41129ef572639c2a166c
Autor:
Ashleigh E Schaffer, Brandon L Taylor, Jacqueline R Benthuysen, Jingxuan Liu, Fabrizio Thorel, Weiping Yuan, Yang Jiao, Klaus H Kaestner, Pedro L Herrera, Mark A Magnuson, Catherine Lee May, Maike Sander
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003274 (2013)
All pancreatic endocrine cell types arise from a common endocrine precursor cell population, yet the molecular mechanisms that establish and maintain the unique gene expression programs of each endocrine cell lineage have remained largely elusive. Su
Externí odkaz:
https://doaj.org/article/65030525071e4b09b2c292d2ae666d77
Autor:
Prashanth Vallabhajosyula, Ming Yu, Wei Wang, Negin Noorchashm Griffith, Chengyang Liu, Divyansh Agarwal, James F. Markmann, Ali Naji, Omaida C. Velazquez, Bernhard J. Hering, Laxminarayana Korutla, Catherine Lee May, Klaus H. Kaestner
Publikováno v:
Nature metabolism
The intrahepatic milieu is inhospitable to intraportal islet allografts1–3, limiting their applicability for the treatment of type 1 diabetes. Although the subcutaneous space represents an alternate, safe and easily accessible site for pancreatic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fdf77ade032bedf60f503aa1011438
https://doi.org/10.1038/s42255-020-0269-7
https://doi.org/10.1038/s42255-020-0269-7
Autor:
Maria L. Golson, Catherine Lee May, Michelle Lee, Ali Naji, James A. Pippin, Klaus H. Kaestner, Struan F.A. Grant, Matthew C. Pahl, Keith Boehm, Long Gao, Su Chun, Andrew D. Wells, Chengyang Liu
Three-dimensional (3D) chromatin organization maps help to dissect cell type-specific gene regulatory programs. Furthermore, 3D chromatin maps have contributed to elucidating the pathogenesis of complex genetic diseases by connecting distal regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0a612036212371249172c515d66b61
https://doi.org/10.1101/2021.11.30.470653
https://doi.org/10.1101/2021.11.30.470653
Autor:
Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati
Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3b260fea454b269889d4ef860f3f7c
https://doi.org/10.1101/2021.06.06.447246
https://doi.org/10.1101/2021.06.06.447246
Autor:
Jason H. Moore, Golnaz Vahedi, Maria L. Golson, Michael R. Betts, Yue J. Wang, Gregory W. Schwartz, Jonathan Schug, Chengyang Liu, Minghui Wu, Ali Naji, Daniel Traum, Klaus H. Kaestner, Ayano Kondo, Ashleigh Morgan, Alberto Sada Japp, Naomi Goldman, Catherine Lee May, Robert B. Faryabi, Michael Feldman, Jinping Liu, Wenliang Wang, Maria Fasolino
Type 1 diabetes (T1D) is an autoimmune disease of only partially defined etiology in which immune cells destroy insulin-producing beta cells. Using single-cell transcriptomics and an advanced analytical strategy to assess pancreatic islets of T1D, au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1041185e816ab93959c99374371ad4c
https://doi.org/10.1101/2021.01.28.428598
https://doi.org/10.1101/2021.01.28.428598
Autor:
Johanna Murray, Jingxuan Liu, Aiping Du, Erik Walp, Chad S. Hunter, Roland Stein, Catherine Lee May, Benjamin Ediger
Publikováno v:
Journal of Biological Chemistry. 286:15352-15360
Aristaless related homeodomain protein (Arx) specifies the formation of the pancreatic islet α-cell during development. This cell type produces glucagon, a major counteracting hormone to insulin in regulating glucose homeostasis in adults. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edca72d1e3ed07220a64cef0c5943c01
https://doi.org/10.1074/jbc.m111.231670
https://doi.org/10.1074/jbc.m111.231670