Výsledky vyhledávání - "Catherine L. Sheppard"

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression

Autor: Krishna C. Yalla, Elaine Huston, George S. Baillie, Elaine V. Hill, Miles D. Houslay, Louisa C.Y. Lee, David Henderson, Catherine L. Sheppard, Daniel M. Houslay, Allan J. Dunlop, Lynne S. Cairns, Diana F. Anthony

Publikováno v: Cellular Signalling. 26:1958-1974

In Rat-1 cells, the dramatic decrease in the levels of both intracellular cyclic 3'5' adenosine monophosphate (cyclic AMP; cAMP) and in the activity of cAMP-activated protein kinase A (PKA) observed in mitosis was paralleled by a profound increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12908b4e4d0dd5566261a6d7a493242
https://doi.org/10.1016/j.cellsig.2014.04.023

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Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Autor: Elaine V. Hill, Eberhard Krause, Catherine L. Sheppard, York-Fong Cheung, Miles D. Houslay, Irene Gall

Publikováno v: Cellular signalling. 18(11)

RAW macrophages, which express the PDE4D3 and PDE4D5 cAMP phosphodiesterase isoforms, exhibited increased PDE4 activity when challenged with H2O2 in a fashion that was negated by treatment with the cell permeant antioxidant, N-acetyl cysteine and by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6275baf13595eb1b8db15c4d1db3258f
https://pubmed.ncbi.nlm.nih.gov/16973330

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