Translating Ribosome Affinity Purification (TRAP) of Cell Type-specific mRNA from Mouse Brain Lysates

Autor: Catherine L, Salussolia, Kellen D, Winden, Mustafa, Sahin

Publikováno v: Bio Protoc

Mammalian tissues are highly heterogenous and complex, posing a challenge in understanding the molecular mechanisms regulating protein expression within various tissues. Recent studies have shown that translation at the level of the ribosome is highl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4576e1dea42fc5b6b8ebe13b59818b6c
https://doi.org/10.21769/bioprotoc.4407

Stroke After Cardiac Catheterization in Children

Autor: Miya E. Bernson-Leung, Jessica H. Chao, Amy R. Danehy, Robert Whitehill, Sonali Sen, Patrick Vittner, Michael J. Rivkin, Catherine L. Salussolia, Dana B. Harrar

Publikováno v: Pediatric Neurology. 100:42-48

Background Children with cardiac disease are at high risk for stroke. Approximately one-quarter of strokes in children with cardiac disease occur in the peri-procedural period; yet, the risk factors, clinical presentation, and treatment of post-cathe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b74838fe47702d3657e123bc48bb84c
https://doi.org/10.1016/j.pediatrneurol.2019.07.005

Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts

Autor: Maria Sundberg, Achint Singh, Kellen D. Winden, Jasbir S. Dalal, Truc Thanh Pham, Catherine L. Salussolia, Pingzhu Zhou, Meghan T. Miller, William T. Pu, Mustafa Sahin

Publikováno v: eLife
eLife, Vol 10 (2021)

Tuberous sclerosis complex (TSC) is a genetic disorder that is associated with multiple neurological manifestations. Previously, we demonstrated that Tsc1 loss in cerebellar Purkinje cells (PCs) can cause altered social behavior in mice. Here, we per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96f1dd4994220b81b32751e5e28fb01
https://pubmed.ncbi.nlm.nih.gov/34259631

Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia

Autor: Yoshihisa Takiyama, Stefanie Brock, Jennifer Hirst, Niklas Dahl, Radka Kremlikova Pourova, Andrea Martinuzzi, Seth Perlman, Helene Verhelst, Omnia Fathy El-Rashidy, Nour Elkhateeb, Sarah I. Sheikh, Jamal Ghoumid, Erin Carmody, Georgia Xiromerisiou, Diego Miguel, James T. Bennett, Barbara Brechmann, William O. Walker, David Dacruz-Álvarez, Mathieu Anheim, Dana M. Jensen, Stefan Kölker, Uzma Shamshad, Darius Ebrahimi-Fakhari, Grace Yoon, Katharina Vill, David Bearden, Adel A. Mahmoud, Sheela Nampoothiri, Devorah Segal, Antje Wiesener, Shenela Lakhani, Joseph G. Gleeson, Chirag Patel, Angelica D'Amore, Abdelrahim Abdrabou Sadek, Marvin Ziegler, Mustafa Sahin, Toni S. Pearson, Julian Teinert, Kira A. Dies, Christopher J. Yuskaitis, Catherine L. Salussolia, Lubov Blumkin, Jonathan Baets, Laura Robelin, Daniel Ebrahimi-Fakhari, Parham Habibzadeh, Anju Shukla, Peter O. Bauer, Saskia Bulk, Afshin Saffari, Elizabeth Lim-Melia, Michael C. Kruer, Christian Beetz, Andreas Ziegler, Pankaj B. Agrawal, Thomas Bourinaris, Filippo M. Santorelli, Mireille Guillot, Abdullah Alamri, Mohammad Ali Faghihi, Kathrin Eberhardt, Thomas Smol, Henry Houlden, Nur Aydinli, Constanze Heine, Soroor Inaloo, Anaita Udwadia-Hegde, Alejandro Brea-Fernández, Yasemin Alanay, Rachana Dubey Gupta, Ayse Aksoy, Agathe Roubertie, Jens Volkmann, Basil T. Darras, Hendrik Langen, Mauricio R. Delgado, Jan Ulrich Schlump, Gregory Geisel, Anna Jansen, Somayeh Bakhtiari, Steven P. Miller, Miriam Wimmer, Maha S. Zaki, Premsai Nagabhyrava, Robert Behne, Hossein Darvish

Publikováno v: Brain

Bi-allelic loss-of-function variants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly understood forms of childhood-onset and complex hereditary spastic paraplegia: SPG47 (AP4B1), SPG50 (AP4M1), SP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16bcaf88226cde8fedce925b8e3ea36
https://pubmed.ncbi.nlm.nih.gov/33294911

Abstract TP506: Decreasing the Time to Detection of Stroke After Cardiac Catheterization in Children

Autor: Jessica H. Chao, Maski Kiran, Michael J. Rivkin, Catherine L. Salussolia, Sonali Sen, Patrick Vittner, Loren Brown, Kush Kapur, Alexandra Fialkow, Miya E. Bernson-Leung, Dana B. Harrar

Publikováno v: Stroke. 50

Introduction: Children with congenital and acquired heart disease are at high risk for stroke. One-quarter of acute ischemic strokes (AIS) in children with cardiac disease occur in the peri-procedural period. Children with AIS can be treated successf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc73dc4051caf04a0f80ecba2cce0ba1
https://doi.org/10.1161/str.50.suppl_1.tp506