Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Catherine L. Nezich"'
Autor:
Joseph R. Patterson, Warren D. Hirst, Jacob W. Howe, Christopher P. Russell, Allyson Cole-Strauss, Christopher J. Kemp, Megan F. Duffy, Jared Lamp, Andrew Umstead, Michael Kubik, Anna C. Stoll, Irving E. Vega, Kathy Steece-Collier, Yi Chen, Anne C. Campbell, Catherine L. Nezich, Kelly E. Glajch, Caryl E. Sortwell
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract β2-adrenoreceptor (β2AR) agonists have been associated with a decreased risk of developing Parkinson’s disease (PD) and are hypothesized to decrease expression of both alpha-synuclein mRNA (Snca) and protein (α-syn). Effects of β2AR ag
Externí odkaz:
https://doaj.org/article/1490e19ae927454fbbfea97a835eff52
Autor:
Warren D. Hirst, Edward Guilmette, Yi Chen, Heiko Runz, Andreas Weihofen, Justin W. Nicholatos, G. Campbell Kaynor, Evgeny Shlevkov, Ellen A. Tsai, Daniel J. Apicco, YuTing Liu, Khanh-Dung H. Nguyen, Collin M. Bantle, Kelly E. Glajch, Lan T. Dang, Joost Groot, Jessica A. Hurt, Catherine L. Nezich, David T. Tran, Neeta A. Abraham
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease of aging, affecting approximately 10 million patients worldwide with no approved therapies to modify progression of disease. Further understanding of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb3ec65a00961d85ce63c47c5a6b5d9
https://doi.org/10.1073/pnas.2006476118
https://doi.org/10.1073/pnas.2006476118
Autor:
Catherine L Nezich, Richard J Youle
Publikováno v:
eLife, Vol 2 (2013)
Ensuring that mitochondrial DNA is successfully divided between daughter mitochondria involves a complex series of interactions with the endoplasmic reticulum and a variety of enzymes.
Externí odkaz:
https://doaj.org/article/7a37294cb6144c4ba3c9f342a7b86f05
Autor:
Xufeng Wu, Richard J. Youle, Catherine L. Nezich, John A. Hammer, Jose Norberto S. Vargas, Zhe Zhang, Shiori Sekine, Jonathon L. Burman, Sarah Pickles, Alice M. Youle, Chunxin Wang
Publikováno v:
Journal of Cell Biology. 216:3231-3247
Within the mitochondrial matrix, protein aggregation activates the mitochondrial unfolded protein response and PINK1–Parkin-mediated mitophagy to mitigate proteotoxicity. We explore how autophagy eliminates protein aggregates from within mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdca274d0a36d45bb5e538edf9fedf71
https://doi.org/10.1083/jcb.201612106
https://doi.org/10.1083/jcb.201612106
Publikováno v:
Journal of Biological Methods
OpenArray is one of the most high-throughput qPCR platforms available but its efficiency can be limited by sample preparation methods that are slow and costly. To optimize the sample workflow for high-throughput qPCR processing by OpenArray, small-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9a5e17b6d646a328de1536194837d1
https://doi.org/10.14440/jbm.2021.339
https://doi.org/10.14440/jbm.2021.339
Publikováno v:
The Journal of Cell Biology
The transcription factor TFEB is activated in a Parkin- and Atg5-dependent manner during mitophagy, and MiT/TFE transcription factor family members are required for the efficient clearance of damaged mitochondria.
The kinase PINK1 and ubiquitin
The kinase PINK1 and ubiquitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a6f177570af5e279a263213bc3d943
https://doi.org/10.1083/jcb.201501002
https://doi.org/10.1083/jcb.201501002
Publikováno v:
Molecular and Cellular Neuroscience. 55:1-12
Mitochondrial diseases comprise a heterogeneous group of disorders characterized by compromised energy production. Since the early days of mitochondrial medical genetics, it has been known that these can be caused by defects in mitochondrial protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feca50634896f8c7bb14eed953bc933
https://doi.org/10.1016/j.mcn.2012.08.013
https://doi.org/10.1016/j.mcn.2012.08.013
Autor:
Lisa Pillow, Shayantani Mukherjee, S. Patrick Walton, Catherine L. Nezich, Pratheeba Palasuberniam, Christina Chan, Michael Feig, Betul Bilgin, Hyunju Cho
PKR (double-stranded RNA-activated protein kinase) is an important component of the innate immunity, antiviral and apoptotic pathways. Recently, our group found that palmitate, a saturated fatty acid, is involved in apoptosis by reducing the autophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc10cdf9e333e918f1a89f936612718f
https://europepmc.org/articles/PMC3035770/
https://europepmc.org/articles/PMC3035770/
