Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Catherine L Tooke"'
Autor:
Agata Butryn, Philipp S. Simon, Pierre Aller, Philip Hinchliffe, Ramzi N. Massad, Gabriel Leen, Catherine L. Tooke, Isabel Bogacz, In-Sik Kim, Asmit Bhowmick, Aaron S. Brewster, Nicholas E. Devenish, Jürgen Brem, Jos J. A. G. Kamps, Pauline A. Lang, Patrick Rabe, Danny Axford, John H. Beale, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L. S. Storm, Tiankun Zhou, Shigeki Owada, Rie Tanaka, Kensuke Tono, Gwyndaf Evans, Robin L. Owen, Frances A. Houle, Nicholas K. Sauter, Christopher J. Schofield, James Spencer, Vittal K. Yachandra, Junko Yano, Jan F. Kern, Allen M. Orville
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Currently many of the time resolved serial femtosecond (SFX) crystallography experiments are done with light driven protein systems, whereas the reaction initiation for non-light triggered enzymes remains a major bottle neck. Here, the authors presen
Externí odkaz:
https://doaj.org/article/55ce2079723b464484f4eed86828b06d
Autor:
Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that di
Externí odkaz:
https://doaj.org/article/b7b931b90cef4f15b5875e2a595d88ff
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Publikováno v:
eLife, Vol 10 (2021)
Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and co
Externí odkaz:
https://doaj.org/article/7aac1beac51a40888c31f6d01e330204
Autor:
Anka Lucic, Tika R. Malla, Karina Calvopiña, Catherine L. Tooke, Jürgen Brem, Michael A. McDonough, James Spencer, Christopher J. Schofield
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 396 (2022)
Carbapenems are important antibacterials and are both substrates and inhibitors of some β-lactamases. We report studies on the reaction of the unusual carbapenem biapenem, with the subclass B1 metallo-β-lactamases VIM-1 and VIM-2 and the class A se
Externí odkaz:
https://doaj.org/article/8730b4a5f64843a4aabb65b739538a10
Autor:
Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
Publikováno v:
Tooke, C L, Hinchliffe, P, Beer, M, Zinovjev, K, Colenso, C K, Schofield, C J, Mulholland, A J & Spencer, J 2023, ' Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase ', Journal of the American Chemical Society, vol. 145, no. 13, pp. 7166-7180 . https://doi.org/10.1021/jacs.2c12123
KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c97774ccd121ac85e5e4f7e2ef074a
https://hdl.handle.net/1983/c1ddb86c-11e5-4b02-9062-d77f3e36a9db
https://hdl.handle.net/1983/c1ddb86c-11e5-4b02-9062-d77f3e36a9db
Autor:
Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
KPC-2 (Klebsiella pneumoniaecarbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ef8b8613c4bc3d2d7e2c5e2ca429b5
https://doi.org/10.1101/2022.11.11.516172
https://doi.org/10.1101/2022.11.11.516172
Autor:
Nicholas K. Sauter, Pauline A. Lang, Philipp S. Simon, Nicholas E. Devenish, Philip Hinchliffe, Vittal K. Yachandra, Junko Yano, Julien Orlans, Jürgen Brem, Gabriel Leen, Pierre Aller, Allen M. Orville, John H. Beale, James Spencer, Jos J. A. G. Kamps, A. Butryn, Catherine L. Tooke, Robin L. Owen, Ramzi N. Massad, Frances A. Houle, Kensuke Tono, Bradley Davy, Patrick Rabe, Jan Kern, Aaron S. Brewster, A. Ebrahim, Asmit Bhowmick, Tiankun Zhou, Gwyndaf Evans, Selina L. S. Storm, Shigeki Owada, Christopher J. Schofield, Isabel Bogacz, Danny Axford, Rie Tanaka, In-Sik Kim
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24757-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature communications, vol 12, iss 1
Spencer, J, Hinchliffe, P, Tooke, C L, Kern, J F & Orville, A M 2021, ' An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography ', Nature Communications, vol. 12, no. 1, 4461 . https://doi.org/10.1038/s41467-021-24757-7
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-24757-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature communications, vol 12, iss 1
Spencer, J, Hinchliffe, P, Tooke, C L, Kern, J F & Orville, A M 2021, ' An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography ', Nature Communications, vol. 12, no. 1, 4461 . https://doi.org/10.1038/s41467-021-24757-7
Serial femtosecond crystallography has opened up many new opportunities in structural biology. In recent years, several approaches employing light-inducible systems have emerged to enable time-resolved experiments that reveal protein dynamics at high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412b1f930b61320c22b71074e3e52b1d
https://hal.archives-ouvertes.fr/hal-03313024/file/2021_Butryn_Nature_Commun.pdf
https://hal.archives-ouvertes.fr/hal-03313024/file/2021_Butryn_Nature_Commun.pdf
Autor:
Thomas B. Clarke, Alan Armstrong, Thomas Webb, James Spencer, Lindsay E. Evans, Aishwarya Krishna, Dominic C Marshall, Yajing Ma, Catherine L. Tooke, Andrew M. Edwards
Publikováno v:
Evans, L E, Krishna, A, Ma, Y, Webb, T E, Marshall, D C, Tooke, C L, Spencer, J, Clarke, T B, Armstrong, A & Edwards, A M 2019, ' Exploitation of Antibiotic Resistance as a Novel Drug Target : Development of a β-Lactamase-Activated Antibacterial Prodrug ', Journal of Medicinal Chemistry, vol. 62, no. 9, pp. 4411-4425 . https://doi.org/10.1021/acs.jmedchem.8b01923
[Image: see text] Expression of β-lactamase is the single most prevalent determinant of antibiotic resistance, rendering bacteria resistant to β-lactam antibiotics. In this article, we describe the development of an antibiotic prodrug that combines
Autor:
James Spencer, Catherine L. Tooke, Philip Hinchliffe, Yuiko Takebayashi, Viivi H. A. Hirvonen, Charlotte K. Colenso, Eilis C. Bragginton
Publikováno v:
Journal of Molecular Biology
Tooke, C, Hinchliffe, P, Bragginton, E, Colenso, C K, Hirvonen, V, Takebayashi, Y & Spencer, J 2019, ' β-Lactamases and β-Lactamase Inhibitors in the 21st Century ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2019.04.002
Tooke, C, Hinchliffe, P, Bragginton, E, Colenso, C K, Hirvonen, V, Takebayashi, Y & Spencer, J 2019, ' β-Lactamases and β-Lactamase Inhibitors in the 21st Century ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2019.04.002
The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β-lactam ring are the primary resistance mechanism, with multiple enzymes di
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::048becd10c9f4bfd1d13379b4557b5ff
https://doi.org/10.7554/elife.66567.sa2
https://doi.org/10.7554/elife.66567.sa2