Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Catherine K. Yeung"'
Autor:
Kevin A. Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James W. MacDonald, Theo K. Bammler, Justina Calamia, Kenneth E. Thummel, Catherine K. Yeung, Stefanie Countryman, Paul Koenig, Jonathan Himmelfarb, Edward J. Kelly
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of
Externí odkaz:
https://doaj.org/article/080dc77d0559426aa337057d6101081e
Autor:
Kendan A. Jones-Isaac, Kevin A. Lidberg, Catherine K. Yeung, Jade Yang, Jacelyn Bain, Micaela Ruiz, Greta Koenig, Paul Koenig, Stefanie Countryman, Jonathan Himmelfarb, Edward J. Kelly
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Determining the physiological effects of microgravity on the human kidney is limited to relatively insensitive tests of biofluids (blood and urine) that do not return abnormal results until more than 50% of kidney function is lost. We have d
Externí odkaz:
https://doaj.org/article/2dcd7c070b404fad9453959adf71eaa2
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling is accomplished by a combination of filtration, tubular secretion, and re‐absorption. Mechani
Externí odkaz:
https://doaj.org/article/fd27fa7ae8e745ce9d6ffbee8b8c327d
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 9-42 (2022)
Abstract The use of microphysiological systems (MPS) to support absorption, distribution, metabolism, and elimination (ADME) sciences has grown substantially in the last decade, in part driven by regulatory demands to move away from traditional anima
Externí odkaz:
https://doaj.org/article/e6c4c8572ed041ffad92535e2981b330
Autor:
Tomoki Imaoka, Weize Huang, Sara Shum, Dale W. Hailey, Shih-Yu Chang, Alenka Chapron, Catherine K. Yeung, Jonathan Himmelfarb, Nina Isoherranen, Edward J. Kelly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Opioid overdose, dependence, and addiction are a major public health crisis. Patients with chronic kidney disease (CKD) are at high risk of opioid overdose, therefore novel methods that provide accurate prediction of renal clearance (CLr) an
Externí odkaz:
https://doaj.org/article/db5ac2fbd58248ce8a1251ee6b9e7c7a
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Kidneys are critical for the elimination of many drugs and metabolites via the urine, filtering waste and maintaining proper fluid and electrolyte balance. Emerging technologies incorporating engineered three-dimensional (3D) in vitro cell culture mo
Externí odkaz:
https://doaj.org/article/dea9f9876faa4c18a592f3429bcdd270
Autor:
Catherine K. Yeung, Paul Koenig, Stefanie Countryman, Kenneth E. Thummel, Jonathan Himmelfarb, Edward J. Kelly
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 8-10 (2020)
Externí odkaz:
https://doaj.org/article/867fe82959c24c4a864487741f1df38e
Autor:
Matthew G. McDonald, Catherine K. Yeung, Aaron M. Teitelbaum, Amanda L. Johnson, Shinya Fujii, Hiroyuki Kagechika, Allan E. Rettie
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 892-899 (2019)
Vitamin K (VK), in both its phylloquinone and menaquinone forms, has been hypothesized to undergo ω- and β-oxidation on its hydrophobic side chain in order to generate the observed urinary metabolites, K acid I and K acid II, which are excreted pri
Externí odkaz:
https://doaj.org/article/f76ce9485fad4bcdba19644badf8ed00
Autor:
Michael L. Granda, David K. Prince, Oliver Fiehn, Yan Chen, Tanya Rajabi, Catherine K. Yeung, Andrew N. Hoofnagle, Bryan Kestenbaum
Publikováno v:
Kidney360. 4:23-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7da8bccdbaf0b37d1257ca202312b27c
https://doi.org/10.34067/kid.0004172022
https://doi.org/10.34067/kid.0004172022
Autor:
Kevin A. Lidberg, Selvaraj Muthusamy, Mohamed Adil, Anish Mahadeo, Jade Yang, Ranita S. Patel, Lu Wang, Theo K. Bammler, Jonathan Reichel, Catherine K. Yeung, Jonathan Himmelfarb, Edward J. Kelly, Shreeram Akilesh
Publikováno v:
J Am Soc Nephrol
BACKGROUND: The kidneys efficiently filter waste products while retaining serum proteins in the circulation. However, numerous diseases compromise this barrier function, resulting in spillage of serum proteins into the urine (proteinuria). Some studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5642ee3be05f8370982562217d07ec7e
https://doi.org/10.1681/asn.2021060751
https://doi.org/10.1681/asn.2021060751