Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Catherine Jomary"'
Autor:
E. A. Faidley, Edwin M. Stone, Andrew J. Lotery, Robert F. Mullins, Catherine Jomary, Heather T. Daggett
Publikováno v:
Experimental Eye Research. 89:767-773
Age-related macular degeneration (AMD) is a common degenerative disease resulting in injury to the retina, retinal pigment epithelium and choriocapillaris. Recent data from histopathology, animal models and genetic studies have implicated altered reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3363c7b9fea2401d96d7e37b88421f8c
https://doi.org/10.1016/j.exer.2009.07.001
https://doi.org/10.1016/j.exer.2009.07.001
Autor:
Angela J. Cree, Edwin M. Stone, Robert F. Mullins, Stephen E. Jones, Andrew J. Lotery, Xiaoli Chen, Catherine Jomary, Alex MacLeod, Andrew Collins, Sarah Ennis
Publikováno v:
The Lancet. 372:1828-1834
Summary Background Age-related macular degeneration is the most prevalent form of visual impairment and blindness in developed countries. Genetic studies have made advancements in establishing the molecular cause of this disease, identifying mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d4fed6834d4095782315e367a701d6
https://doi.org/10.1016/s0140-6736(08)61348-3
https://doi.org/10.1016/s0140-6736(08)61348-3
Publikováno v:
Journal of Neurochemistry. 64:2370-2373
The human tissue inhibitor of metalloproteinases-3 (TIMP3) gene is the most recently characterized member of a family of genes whose products are implicated in extracellular matrix (ECM) remodelling. We previously described an increase in expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6113e24d6c9d4ab309be64f2383126a0
https://doi.org/10.1046/j.1471-4159.1995.64052370.x
https://doi.org/10.1046/j.1471-4159.1995.64052370.x
Autor:
Steve Jones, Catherine Jomary
Publikováno v:
BioEssays. 24:811-820
Secreted Frizzled-related proteins (SFRPs) are modulators of the intermeshing pathways in which signals are transduced by Wnt ligands through Frizzled (Fz) membrane receptors. The Wnt networks influence biological processes ranging from developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1c46b596a6e74e0dde335f316b4495
https://doi.org/10.1002/bies.10136
https://doi.org/10.1002/bies.10136
Publikováno v:
Molecular and Cellular Neuroscience. 18:335-346
Apoptosis is considered to be the final common pathway of photoreceptor cell death in different inherited retinal diseases. However, apoptosis encompasses diverse pathways of molecular interactions culminating in cellular demise. To begin dissecting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e18598e98a5433fa5985dbeba839aa
https://doi.org/10.1006/mcne.2001.1036
https://doi.org/10.1006/mcne.2001.1036
Publikováno v:
NeuroReport. 11:3963-3967
Inherited retinal degenerations such as retinitis pigmentosa (RP) are characterized by progressive loss of photoreceptors, apparently by apoptosis, and our recent report of increased secreted Frizzled-related protein-2 (SFRP2) in RP retinas suggests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffa5611a12b211b181cf8baa016ac74
https://doi.org/10.1097/00001756-200012180-00012
https://doi.org/10.1097/00001756-200012180-00012
Publikováno v:
Molecular Cell Biology Research Communications. 4:20-25
In the rd/rd mouse model of inherited retinal degeneration, the majority of photoreceptors die apoptotically between postnatal age (P)10 and 20 days, during which period the inner retina appears morphologically unaffected. To examine mRNA changes ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042b6a596c995b4f5860696548d3d8a4
https://doi.org/10.1006/mcbr.2000.0250
https://doi.org/10.1006/mcbr.2000.0250
Publikováno v:
NeuroReport. 9:4161-4165
AlphaB-crystallin, which is abundantly expressed in the lens but also in a diversity of other tissues, functions as a stress-inducible molecular chaperone and is increased in brain neurodegenerative diseases. We compared retinal alphaB-crystallin exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07844cfd0d7b0a425060c11d52ca191e
https://doi.org/10.1097/00001756-199812210-00030
https://doi.org/10.1097/00001756-199812210-00030
Publikováno v:
Biochemical and Biophysical Research Communications. 252:236-240
The homeobox gene Pax-6 is expressed during eye development in both the retina and lens, and Pax-6 mutations cause ocular abnormalities including retinal defects. We investigated the pattern of Pax-6 gene expression in the rd/rd mouse model of inheri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74bf7d90ddcdaef688d92e6789f7b2e
https://doi.org/10.1006/bbrc.1998.9631
https://doi.org/10.1006/bbrc.1998.9631
Publikováno v:
NeuroReport. 8:2169-2172
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is one of a family of genes whose products are implicated in the regulation of remodelling of the extracellular matrix. The level of mRNA coding for TIMP-3 is increased in retinas affected by the phot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf8f207fa8854cce841b56eef34950f
https://doi.org/10.1097/00001756-199707070-00015
https://doi.org/10.1097/00001756-199707070-00015