Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Catherine J. Perez"'
Autor:
Patrick D. O'Connor, William A. Denny, John M. Kelly, Karen L. White, Vicky M. Avery, Melissa Sykes, Amanda F. Francisco, Scott Cornwall, Andrew J. Marshall, Jennifer Riley, Bilal Zulfiqar, Susan A. Charman, Catherine J. Perez, Kevin D. Read, Eric Chatelain, Andrew M. Thompson, R.C. Andrew Thompson, Martine Keenan
Phenotypic screening of a 900 compound library of antitubercular nitroimidazole derivatives related to pretomanid against the protozoan parasite Trypanosoma cruzi (the causative agent for Chagas disease) identified several structurally diverse hits w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f4d7d9298b453cdb9602cabb875e1e
Publikováno v:
Acta Tropica. 178:107-114
The progression of Chagas disease (CD) varies significantly from host to host and is affected by multiple factors. In particular, mixed strain infections and reinfections have the potential to exacerbate disease progression subsequently affecting cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f54aba3cb85691bdbe0c5fac2be0fd4
https://doi.org/10.1016/j.actatropica.2017.11.002
https://doi.org/10.1016/j.actatropica.2017.11.002
Autor:
Pedro W. Crous, G.E.St.J. Hardy, Angus J. Carnegie, Geoff S. Pegg, Vera Andjic, Aaron Maxwell, Michael J. Wingfield, Treena I. Burgess, Catherine J. Perez
Publikováno v:
Forest Ecology and Management, 443, 19-27. Elsevier B.V.
In Australia, during the course of the last two decades, plantation area of Eucalyptus has expanded dramatically. One of the most important threats to these trees, and to the forest industries they sustain, is a complex of fungal diseases broadly tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fed9e7aa4476fcf97596ff198dd2b86
https://pure.knaw.nl/portal/en/publications/eca58f6d-db4f-4982-a720-60c44c8a90e2
https://pure.knaw.nl/portal/en/publications/eca58f6d-db4f-4982-a720-60c44c8a90e2
Autor:
Catherine J. Perez, Alison E. Hillman, Aileen Elliot, R.C. Andrew Thompson, Alan J. Lymbery, Amanda Ash
Publikováno v:
International Journal for Parasitology: Parasites and Wildlife
International Journal for Parasitology: Parasites and Wildlife, Vol 5, Iss 1, Pp 110-115 (2016)
International Journal for Parasitology: Parasites and Wildlife, Vol 5, Iss 1, Pp 110-115 (2016)
The ‘quenda genotype’ of Giardia was first identified in quenda (syn. southern brown bandicoots, Isoodon obesulus) in Western Australia in 2004. We aimed to formally describe this genotype as a species of Giardia, Giardia peramelis. Seventy five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc964f7612cfbab2ac459ffe7329667
https://doi.org/10.1016/j.ijppaw.2016.01.002
https://doi.org/10.1016/j.ijppaw.2016.01.002
Publikováno v:
Trends in Parasitology. 31:595-603
Reactivation of Chagas Disease (CD) is a global public health issue. Reactivation of disease can affect the management of CD and its clinical outcome, adding pressure to global health systems because it exacerbates symptoms, leading to misdiagnosis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd642534147a23d367a9ac7a4a2cf08
https://doi.org/10.1016/j.pt.2015.06.006
https://doi.org/10.1016/j.pt.2015.06.006
Autor:
Martine Keenan, Eileen Ryan, Scott Cornwall, Andrea Khong, Jason H. Chaplin, Wayne M. Best, Karen L. White, R.C. Andrew Thompson, Catherine J. Perez, Ivan Scandale, Susan A. Charman, Michael J. Abbott, Paul W. Alexander, Francis C. K. Chiu, David M. Shackleford, Michael Campbell, Maria Koltun, Eric Chatelain, Adriana Botero, Julia Morizzi, Thomas W. von Geldern
Publikováno v:
Journal of Medicinal Chemistry
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832ff07aa1233c73b2095f1457b219
https://doi.org/10.1021/jm401610c
https://doi.org/10.1021/jm401610c
Autor:
Eric Chatelain, Tatiana Y. Hargrove, Martine Keenan, Michael R. Waterman, Paul W. Alexander, Galina I. Lepesheva, Susan A. Charman, Jason H. Chaplin, Catherine J. Perez, Zdzislaw Wawrzak
Publikováno v:
Journal of Biological Chemistry. 288:31602-31615
Chagas disease, caused by the eukaryotic (protozoan) parasite Trypanosoma cruzi, is an alarming emerging global health problem with no clinical drugs available to treat the chronic stage. Azole inhibitors of sterol 14α-demethylase (CYP51) were prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a301ec53c5e5d30f9c2826f0541adfbf
https://doi.org/10.1074/jbc.m113.497990
https://doi.org/10.1074/jbc.m113.497990
Autor:
Martine Keenan, Eileen Ryan, Susan A. Charman, Jason H. Chaplin, Karen L. White, Eric Chatelain, Gong Chen, Jean-Robert Ioset, Zhisen Wang, Michael J. Abbott, Scott Cornwall, Wayne M. Best, Sarah Keatley, Paul W. Alexander, Thomas W. von Geldern, Hugo Diao, Catherine J. Perez, R.C. Andrew Thompson
Publikováno v:
Future Medicinal Chemistry. 5:1733-1752
Background: Inhibitors of Trypanosoma cruzi with novel mechanisms of action are urgently required to diversify the current clinical and preclinical pipelines. Increasing the number and diversity of hits available for assessment at the beginning of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de70cd8bb075d45ff1f1bb4e212c14b
https://doi.org/10.4155/fmc.13.139
https://doi.org/10.4155/fmc.13.139
Autor:
David M. Shackleford, Karen L. White, Stéphanie Braillard, Catherine J. Perez, Junghyun Goo, Susan A. Charman, Lucio H. Freitas-Junior, Eric Chatelain, Luís Gaspar, Carolina B. Moraes, R.C. Andrew Thompson, Anabela Cordeiro-da-Silva
Publikováno v:
Antimicrobial agents and chemotherapy. 59(6)
With the aim of improving the available drugs for the treatment of Chagas disease, individual enantiomers of nifurtimox were characterized. The results indicate that the enantiomers are equivalent in their in vitro activity against a panel of Trypano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b090d123a8f427abbb8475a63f177503
https://pubmed.ncbi.nlm.nih.gov/25845874
https://pubmed.ncbi.nlm.nih.gov/25845874
Publikováno v:
Trends in parasitology. 30(4)
The debilitating zoonosis Chagas disease (CD) is caused by infection with the flagellate protozoan Trypanosoma cruzi. One century after its discovery, a curative agent remains elusive. Immune evasion by T. cruzi results in a poorly controlled infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114577a0fa5b4a2f04c5892a4e89999d
https://pubmed.ncbi.nlm.nih.gov/24581558
https://pubmed.ncbi.nlm.nih.gov/24581558