Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Catherine J. Merrick"'
Autor:
Holly M. Craven, Guilherme Nettesheim, Pietro Cicuta, Andrew M. Blagborough, Catherine J. Merrick
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 106-119 (2023)
Plasmodium falciparum is the deadliest causative agent of human malaria. This parasite has historically developed resistance to most drugs, including the current frontline treatments, so new therapeutic targets are needed. Our previous work on guanin
Externí odkaz:
https://doaj.org/article/e9371aa70d4440848aa14e1707bd2b4f
Autor:
Hunter L. Gage, Catherine J. Merrick
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background The Plasmodium genus of malaria parasites encodes several families of antigen-encoding genes. These genes tend to be hyper-variable, highly recombinogenic and variantly expressed. The best-characterized family is the var genes, ex
Externí odkaz:
https://doaj.org/article/e9c6e4c4d18745dcb8b2114625918663
Autor:
James Edwards-Smallbone, Anders L. Jensen, Lydia E. Roberts, Francis Isidore G. Totañes, Sarah R. Hart, Catherine J. Merrick
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures.
Externí odkaz:
https://doaj.org/article/c123ac3231b7406dbe0fd9b15841d2c2
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/881b2c6b82614a94be1b9f0aa447ca63
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-13 (2018)
Abstract It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease. Phenotypic scree
Externí odkaz:
https://doaj.org/article/698ed6d1f7e441c893c5ae9894fc2faa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The mechanics of DNA replication and cell cycling are well-characterized in model organisms, but less is known about these basic aspects of cell biology in early-diverging Apicomplexan parasites, which do not divide by canonical binary fissi
Externí odkaz:
https://doaj.org/article/23ef27017c93437bb385de1aeb7f53c9
Autor:
Franck Dumetz, Catherine J. Merrick
Publikováno v:
Molecules, Vol 24, Iss 7, p 1339 (2019)
Guanine-quadruplex (G4) motifs, at both the DNA and RNA levels, have assumed an important place in our understanding of the biology of eukaryotes, bacteria and viruses. However, it is generally little known that their very first description, as well
Externí odkaz:
https://doaj.org/article/6cc52d082d5345fb884a537607acf31a
Autor:
Catherine J. Merrick
Publikováno v:
Trends in Parasitology. 39:12-16
Epigenetic modifications play important roles in the biology of malaria parasites. The new epigenetic mark histone lactylation, discovered only recently in humans, is also present in malaria parasites. It may have important functions as a key player
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118f781a71bd25909105657a68e2df3e
https://doi.org/10.1016/j.pt.2022.10.004
https://doi.org/10.1016/j.pt.2022.10.004
Plasmodium falciparum, a protozoan parasite and causative agent of human malaria, has one of the most A/T-biased genomes sequenced to date. This may give the genome and the transcriptome unusual structural features. Recent progress in sequencing tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6ac75c63781a0d10bf6957b7989271
Malaria parasites undergo a single phase of sexual reproduction in their complex lifecycle. It involves specialised, sexually committed cells called gametocytes, which develop rapidly into mature gametes and mate upon entering the mosquito midgut. Ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57759ac43458ebc0863eabf30e0da463