Výsledky vyhledávání - "Catherine J. Gress"

Chicken Collagen X Regulatory Sequences Restrict Transgene Expression to Hypertrophic Cartilage in Mice

Autor: Catherine J. Gress, Olena Jacenko, Elizabeth H. Appleman, Michelle R. Campbell

Publikováno v: The American Journal of Pathology. 164:487-499

Collagen X is produced by hypertrophic cartilage undergoing endochondral ossification. Transgenic mice expressing defective collagen X under the control of 4.7- or 1.6-kb chicken collagen X regulatory sequences yielded skeleto-hematopoietic defects (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06bcc3fd6f2171c9bd3b0631049ad7f
https://doi.org/10.1016/s0002-9440(10)63139-2

Zobrazit plný text záznamu

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:1483-1486

In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020a8d8d76827308cf4beb670e93f46
https://doi.org/10.1016/s0960-894x(03)00102-1

Zobrazit plný text záznamu

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro

Autor: Maxine Gowen, Catherine J. Gress, Shing Mei Hwang, Michael W. Lark, Michael S. McQueney, Ian E. James, Robert W. Marquis, Simon M. Blake, Ru Yu, Daniel F. Veber, Hye-Ja Oh, Denise Zembryki, Thaddeus A. Tomaszek, Dennis S. Yamashita

Publikováno v: Journal of Biological Chemistry. 276:11507-11511

Cathepsins K and L are related cysteine proteases that have been proposed to play important roles in osteoclast-mediated bone resorption. To further examine the putative role of cathepsin L in bone resorption, we have evaluated selective and potent i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b89bfe824acabaf8fa273601f5802
https://doi.org/10.1074/jbc.m010684200

Zobrazit plný text záznamu

Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors

Publikováno v: Journal of medicinal chemistry. 49(5)

The syntheses, in vitro characterizations, and rat and monkey in vivo pharmacokinetic profiles of a series of 5-, 6-, and 7-methyl-substituted azepanone-based cathepsin K inhibitors are described. Depending on the particular regiochemical substitutio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87988c095a79f414b77817c8a504f022
https://pubmed.ncbi.nlm.nih.gov/16509577

Zobrazit plný text záznamu

Azepanone-based inhibitors of human cathepsin L

Autor: Robert W. Marquis, Dennis S. Yamashita, Thaddeus A. Tomaszek, Simon M. Blake, Priscilla H. Offen, Martha S. Head, Shing-Mei Hwang, Ren Xie, Attiq Rahman, Scott K. Thompson, Ru Yu, Jin Zeng, Ian E. James, Robert E. Lee Trout, Cummings Maxwell D, Michael A. Lark, Daniel F. Veber, Catherine J. Gress

Publikováno v: Journal of medicinal chemistry. 48(22)

The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the homologous cysteine protease cathepsin L is detailed. Structure-activity studies examining the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55b20e3835b8f957914448867db4290
https://pubmed.ncbi.nlm.nih.gov/16250645

Zobrazit plný text záznamu

Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X

Autor: Michelle R. Campbell, Catherine J. Gress, Zhuliang Tao, Olena Jacenko, Patricia M. McManus, Douglas Roberts

Publikováno v: The American journal of pathology. 160(6)

Each skeletal element where marrow develops is first defined by a hypertrophic cartilage blueprint. Through programmed tissue substitution, the cartilaginous skeletal model is replaced by trabecular bone and marrow, with accompanying longitudinal tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0f2332ac13db6ff018b278508e3210
https://pubmed.ncbi.nlm.nih.gov/12057907

Zobrazit plný text záznamu

Azepanone-based inhibitors of human and rat cathepsin K

Publikováno v: Journal of medicinal chemistry. 44(9)

The synthesis, in vitro activities, and pharmacokinetics of a series of azepanone-based inhibitors of the cysteine protease cathepsin K (EC 3.4.22.38) are described. These compounds show improved configurational stability of the C-4 diastereomeric ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869edd5069e660d644d9b841b87cde41
https://pubmed.ncbi.nlm.nih.gov/11311061

Zobrazit plný text záznamu

FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis

Autor: A.T. Hand, M.W. Lark, M. Gowen, M.R. Barnes, Shaji Kumar, K. Williams, R.A. Dodds, B.R. Bradley, Scott E Grabill, Catherine J. Gress, J.R. Connor, D.A. Campbell, Simon M. Blake, Ian E. James

Publikováno v: Osteoarthritis and cartilage. 8(6)

Objective To characterize a novel secreted frizzled-related protein (SFRP) and determine its tissue distribution at the mRNA and protein level. Methods The FrzB-2 gene was identified by expressed sequence tag (EST) analysis of human tissue-derived li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08c8c63de746e0255bf7fe7bd136ab4
https://pubmed.ncbi.nlm.nih.gov/11069730

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání