Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Catherine J. Fricano-Kugler"'
Autor:
Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M. Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-Ya Gilbert, Yan Ao, Jing Ou, Catherine J. Fricano-Kugler, Jeffrey L. Goldberg, Zhigang He, Clifford J. Woolf, Michael V. Sofroniew, Larry I. Benowitz, Daniel H. Geschwind
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Here the authors couple an integrative genomic analysis with substantial in vitro and in vivo experimental validation, identifying REST as a novel suppressor of a pro-regenerative gene program and CNS axon regeneration in mice.
Externí odkaz:
https://doaj.org/article/df6521e5d58e42ea8efb14302c66060b
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146721 (2016)
A conventional study design among medical and biological experimentalists involves collecting multiple measurements from a study subject. For example, experiments utilizing mouse models in neuroscience often involve collecting multiple neuron measure
Externí odkaz:
https://doaj.org/article/9946ccf96f684935bac4974116367380
Autor:
Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M. Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-Ya Gilbert, Yan Ao, Jing Ou, Catherine J. Fricano-Kugler, Jeffrey L. Goldberg, Zhigang He, Clifford J. Woolf, Michael V. Sofroniew, Larry I. Benowitz, Daniel H. Geschwind
Publikováno v:
Nature communications, vol 13, iss 1
The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances have uncovered an intrinsic program that involves coordinate regulati
Autor:
Clifford J. Woolf, Alexander M. Bernstein, Kun Gao, Jing Ou, Larry I. Benowitz, Alice Zhang, Jeffrey L. Goldberg, Riki Kawaguchi, Hui-ya Gilbert, Yuyan Cheng, Michael V. Sofroniew, Catherine J. Fricano-Kugler, Yan Ao, Daniel H. Geschwind, Kyra Potter, Yuqin Yin
The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances have uncovered an intrinsic program that involves coordinate regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86b585520265ac2a60d2e26264e0a9e
https://doi.org/10.21203/rs.3.rs-102518/v1
https://doi.org/10.21203/rs.3.rs-102518/v1
Autor:
Michael R. Williams, Stephanie A. Getz, Erika L. Moen, Bryan W. Luikart, Tyrone DeSpenza, Paul W. Frazel, Alistair J. O'Malley, Catherine J. Fricano-Kugler, Ashley A. Zurawel, Meijie Li
Publikováno v:
Biol Psychiatry
Background Phosphatase and tensin homolog (PTEN) negatively regulates downstream protein kinase B signaling, resulting in decreased cellular growth and proliferation. PTEN is mutated in a subset of children with autism spectrum disorder (ASD); howeve
Autor:
Julia R. Salinaro, Catherine J. Fricano-Kugler, Bryan W. Luikart, Meijie Li, Michael R. Williams
Publikováno v:
Journal of Visualized Experiments : JoVE
Replication defective lentiviruses or retroviruses are capable of stably integrating transgenes into the genome of an infected host cell. This technique has been widely used to encode fluorescent proteins, opto- or chemo-genetic controllers of cell a
Autor:
Christian P. Rizzuto, Stephanie A. Getz, Catherine J. Fricano-Kugler, Joseph S. Geller, Patrick D. Skelton, Bryan W. Luikart, Michael R. Williams, Meijie Li, Jeonghoon Lee
Publikováno v:
Scientific Reports
Retroviruses expressing a fluorescent protein, Cas9 and a small guide RNA are used to mimic nonsense PTEN mutations from autism patients in developing mouse neurons. We compare the cellular phenotype elicited by CRISPR-Cas9 to those elicited using sh